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公开(公告)号：US09877862B2
公开(公告)日：2018-01-30
申请号：US12608168
申请日：2009-10-29
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A system for treating obstructive sleep apnea includes a first element implantable in a tongue and a second element implantable between muscle planes of an inframandibular region. The second element has a first end coupled with the first element and a second end coupled with a hyoid bone for preventing the base of the tongue from collapsing against an opposing pharyngeal wall during sleep. The first and second implantable elements have outer surfaces that are substantially impermeable to tissue in-growth to allow for post-surgical adjustment or removal, if necessary. The first implantable element is elongated and includes a first end, a second end, and a center section located between the first and second ends. The center section is implantable in the tongue, and the first and second ends of the first implantable element are advanceable beneath the tongue for being coupled with the anterior end of the second implantable element.
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公开(公告)号：US20140305443A1
公开(公告)日：2014-10-16
申请号：US14303722
申请日：2014-06-13
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56 , A61F2210/009 , A61N2/06
摘要： Magnetic devices and implantation methods are provided for use in the treatment of obstructive sleep apnea. The devices include a sheet-like element having ferromagnetic qualities. The device may also include a permanent magnet attached to the sheet-like element by magnetic forces. The devices are implanted in soft tissue surrounding the airway and in tissue space beneath the pharyngeal wall to exert forces on and/or change the shape of the soft tissue. The magnetic devices may also include a bladder containing a magnetorheological fluid that stiffens soft tissue when exposed to a magnetic field.
摘要翻译： 提供磁性装置和植入方法用于治疗阻塞性睡眠呼吸暂停。 这些装置包括具有铁磁性质的片状元件。 该装置还可以包括通过磁力附着到片状元件的永磁体。 将装置植入围绕气道的软组织和咽壁下方的组织空间中以施加力和/或改变软组织的形状。 磁性装置还可以包括含有磁流变流体的气囊，当暴露于磁场时，磁流体流体会软化软组织。
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公开(公告)号：US08783258B2
公开(公告)日：2014-07-22
申请号：US12325350
申请日：2008-12-01
IPC分类号： A61F5/37 , A61F13/00 , A61C5/14 , A61B19/00 , A61B17/56 , A61F5/04 , A61B17/58 , A61F2/30 , A61B17/70 , A61F2/20 , A61F2/02 , A61F2/08
CPC分类号： A61F5/566
摘要： A system for treating obstructive sleep apnea includes an anchoring element having scar tissue located in an inframandibular region, and a tongue implant having at least one arm extending therefrom, whereby the tongue implant is implantable in a tongue with the at least one arm being connectable with the anchoring element for coupling the tongue implant with the anchoring element. In one embodiment, the anchoring element includes a first implant part such as a flexible layer implantable in the inframandibular region and the scar tissue is formed on, in, and/or around the first implant part. The tongue implant is coupled with the anchoring element and/or the scar tissue through the at least one arm. The length of the at least one arm may be adjusted for shifting the tongue anteriorly.
摘要翻译： 用于治疗阻塞性睡眠呼吸暂停的系统包括具有位于下颌区域中的瘢痕组织的锚定元件和具有从其延伸的至少一个臂的舌植入物，由此所述舌植入物可植入舌头中，所述至少一个臂可与 用于将舌植入物与锚定元件联接的锚固元件。 在一个实施例中，锚定元件包括第一植入部分，例如可植入在下颌下区域中的柔性层，并且瘢痕组织形成在第一植入部分上，内和/或周围。 舌植入物通过至少一个臂与锚定元件和/或瘢痕组织联接。 可以调节至少一个臂的长度以使舌头向前移动。
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公开(公告)号：US08413661B2
公开(公告)日：2013-04-09
申请号：US12228681
申请日：2008-08-14
摘要： A pharyngeal retractor device and implantation methods are provided for use in the treatment of obstructive sleep apnea. The device includes a retracting element and a tissue engaging element that promotes tissue ingrowth around or onto the retracting element. The device is implanted in tissue space beneath the pharyngeal wall to alter the shape of the wall. The device may be implanted through the oral cavity alone or by using a trocar or a hand-held delivery system to deliver the device through the pharyngeal wall. Alternatively, the device may be implanted using an open, direct visualization approach from the side of a patient's neck.
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公开(公告)号：US06808518B2
公开(公告)日：2004-10-26
申请号：US09965949
申请日：2001-09-28
IPC分类号： A61M3100
CPC分类号： A61M37/0015 , A61M25/1011 , A61M29/02 , A61M37/00 , A61M2025/105 , A61M2025/1052 , A61M2025/1086 , A61M2037/003
摘要： The present invention provides a mechanism by which the physical properties of diseased blood vessel walls can be manipulated to achieve an effective vessel lumen diameter for a prolonged period of time. The methods and devices of the present invention selectively isolate and treat the medial or adventitial layers of these diseased blood vessels. The invention is based on the delivery of proteolytic enzymes and crosslinking agents via specialized delivery devices to a select layer of the diseased blood vessel wall. By isolating and treating these layers of the artery, collagen degrading and collagen crosslinking agents can be delivered so as to affect the diameter of the blood vessels and control blood flow therein.
摘要翻译： 本发明提供了一种机制，通过该机制可以操纵患病血管壁的物理性能以在更长的时间内实现有效的血管腔直径。 本发明的方法和装置选择性地分离和治疗这些患病血管的内侧或外膜层。 本发明基于通过专门的递送装置将蛋白水解酶和交联剂递送到患病血管壁的选择层。 通过分离和处理这些动脉层，可以递送胶原蛋白降解和胶原交联剂，以便影响血管的直径并控制其中的血流。
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6.发明授权Device for attaching, relocating and reinforcing tissue and methods of using same 有权用于附着，重新定位和加强组织的装置及其使用方法公开(公告)号：US08894683B2
公开(公告)日：2014-11-25
申请号：US12151235
申请日：2008-05-05
CPC分类号： A61B17/0401 , A61B2017/00004 , A61B2017/00743 , A61B2017/00778 , A61B2017/00805 , A61B2017/0412 , A61B2017/0427 , A61B2017/0454 , A61B2017/0458 , A61B2017/0462 , A61B2017/0464 , A61F2/0045
摘要： A device for attaching, relocating or reinforcing tissue includes a first tissue anchoring portion having a support plate and a plurality of barbs extending from the support plate for engaging tissue at a first location, a second tissue anchoring portion having a support plate and a plurality of barbs extending from the support plate for engaging tissue at a second location which is different from the first location, and a connection element, such as a suture or a mesh structure, interposed between and interconnecting the first tissue anchoring portion and the second tissue anchoring portion. The support plate of at least one of the first tissue anchoring portion and the second tissue anchoring portion may have longitudinally axially formed therethrough a bore for receiving the connecting element so that the surgeon may pull on the end of the connecting element to adjust the distance between the first tissue anchoring portion and the second tissue anchoring portion.
摘要翻译： 用于附接，重新定位或加强组织的装置包括具有支撑板的第一组织锚固部分和从支撑板延伸的多个倒钩，用于在第一位置处接合组织，第二组织锚定部分具有支撑板和多个 从支撑板延伸的倒钩，用于在不同于第一位置的第二位置处接合组织;以及连接元件，例如缝合线或网状结构，插入在第一组织锚固部分和第二组织锚定部分之间并将其互连 。 第一组织锚固部分和第二组织锚固部分中的至少一个的支撑板可以纵向轴向地形成在其中，用于接收连接元件的孔，使得外科医生可以在连接元件的端部上拉动以调节 第一组织锚定部分和第二组织锚定部分。
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7.发明授权Methods and devices for the indirect displacement of the hyoid bone for treating obstructive sleep apnea 有权舌骨间接移位用于治疗阻塞性睡眠呼吸暂停的方法和装置公开(公告)号：US08561616B2
公开(公告)日：2013-10-22
申请号：US12257563
申请日：2008-10-24
CPC分类号： A61F5/566
摘要： An implant for treating obstructive sleep apnea includes an elongated body having a central region, a first end, and a second end opposite the first end. The central region of the elongated body engages inframandibular musculature that extends between a mandible and a hyoid bone. The first and second ends of the elongated body are optionally anchored to the mandible. The elongated body is under tension for urging the inframandibular musculature in an inferior direction, which, in turn, pulls the hyoid bone anteriorly for minimizing the likelihood of occurrence of obstructive sleep apnea episodes.
摘要翻译： 用于治疗阻塞性睡眠呼吸暂停的植入物包括具有中心区域，第一端和与第一端相对的第二端的细长体。 细长体的中心区域接合在下颌骨和舌骨之间延伸的下颌骨肌肉组织。 细长体的第一和第二端可选地被锚定到下颌骨。 细长的身体处于紧张状态，用于沿较低的方向推动下颌骨肌肉组织，这又反过来拉动舌骨前方以最小化发生阻塞性睡眠呼吸暂停发作的可能性。
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公开(公告)号：US20130174857A1
公开(公告)日：2013-07-11
申请号：US13784077
申请日：2013-03-04
IPC分类号： A61F5/56
摘要： A pharyngeal retractor device and implantation methods are provided for use in the treatment of obstructive sleep apnea. The device includes a retracting element and a tissue engaging element that promotes tissue ingrowth around or onto the retracting element. The device is implanted in tissue space beneath the pharyngeal wall to alter the shape of the wall. The device may be implanted through the oral cavity alone or by using a trocar or a hand-held delivery system to deliver the device through the pharyngeal wall. Alternatively, the device may be implanted using an open, direct visualization approach from the side of a patient's neck.
摘要翻译： 提供咽收缩器装置和植入方法用于治疗阻塞性睡眠呼吸暂停。 该装置包括回缩元件和组织接合元件，其促进组织向内生长在收缩元件周围或上。 该装置植入咽壁下方的组织空间以改变壁的形状。 该装置可以单独地通过口腔植入，或者通过使用套管针或手持递送系统将装置输送通过咽壁。 或者，可以使用来自患者颈部侧面的开放的直接可视化方法来植入该装置。
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公开(公告)号：US20100132719A1
公开(公告)日：2010-06-03
申请号：US12325350
申请日：2008-12-01
CPC分类号： A61F5/566
摘要： A system for treating obstructive sleep apnea includes an anchoring element having scar tissue located in an inframandibular region, and a tongue implant having at least one arm extending therefrom, whereby the tongue implant is implantable in a tongue with the at least one arm being connectable with the anchoring element for coupling the tongue implant with the anchoring element. In one embodiment, the anchoring element includes a first implant part such as a flexible layer implantable in the inframandibular region and the scar tissue is formed on, in, and/or around the first implant part. The tongue implant is coupled with the anchoring element and/or the scar tissue through the at least one arm. The length of the at least one arm may be adjusted for shifting the tongue anteriorly.
摘要翻译： 用于治疗阻塞性睡眠呼吸暂停的系统包括具有位于下颌区域中的瘢痕组织的锚定元件和具有从其延伸的至少一个臂的舌植入物，由此所述舌植入物可植入舌头中，所述至少一个臂可与 用于将舌植入物与锚定元件联接的锚固元件。 在一个实施例中，锚定元件包括第一植入部分，例如可植入在下颌下区域中的柔性层，并且瘢痕组织形成在第一植入部分上，内和/或周围。 舌植入物通过至少一个臂与锚定元件和/或瘢痕组织联接。 可以调节至少一个臂的长度以使舌头向前移动。
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公开(公告)号：US20070156161A1
公开(公告)日：2007-07-05
申请号：US11322144
申请日：2005-12-29
IPC分类号： A61B17/32
CPC分类号： A61B10/0275 , A61B10/0283 , A61B17/32002 , A61B2010/0225 , A61B2017/00084 , A61B2017/00792 , A61B2017/00902 , A61B2017/00969 , A61B2017/320028 , A61B2018/00005 , A61M1/0062 , A61M1/0064 , A61M2202/08
摘要： A device for repositioning tissue includes a hand held main body having a housing which defines a chamber for holding tissue. The chamber is connected to a negative pressure source to create a vacuum in the chamber. A flexible cannula is affixed to the main body, and includes a distal end and a proximate end, with openings through the thickness of the walls of each. The cannula defines a hollow lumen which is in communication with the distal end opening and the proximate end opening and the tissue holding chamber. The distal end of the cannula may be positioned in proximity to a patient's body to receive tissue therefrom through the distal end opening and to transport the tissue through the lumen and proximate end opening to the tissue holding chamber in response to the vacuum created in the tissue holding chamber.
摘要翻译： 用于重新定位组织的装置包括手持主体，其具有限定用于保持组织的室的壳体。 腔室连接到负压源以在腔室中产生真空。 柔性套管固定到主体上，并且包括远端和近端，其中穿过每个壁的厚度的开口。 套管限定了与远端开口和近端开口以及组织保持室连通的中空管腔。 套管的远端可以定位在患者身体附近以通过远端开口接收组织，并且响应于在组织中产生的真空而将组织输送通过内腔和近端端开口到组织保持室 控股室
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