公开(公告)号：US20180116868A1

公开(公告)日：2018-05-03

申请号：US15798489

申请日：2017-10-31

Applicant: Christopher J.P. Velis ,  Cole C. Velis ,  Karen Miller

Inventor： Christopher J.P. Velis ,  Cole C. Velis ,  Karen Miller

IPC: A61F7/12 ,  A61F7/00

CPC classification number: A61F7/12 ,  A61F7/0085 ,  A61F2007/0063 ,  A61F2007/126

Abstract: The present invention involves the use of a small profile device for preparation and/or delivery of cold slurry into the human body. The cold slurry can be generated within the device itself or within a separate small chamber, both of which produce a cold slurry using a cooling source and an injectable fluid. The delivery device provides continued agitation to the fluid/slurry through rotation and/or vibration of blades within the device. The fluid/cold slurry is cooled/kept cool through the use of an external cooling device, such as a cooling sleeve, that at least partially surrounds the delivery device. The cooling sleeve can cool or maintain the temperature of the cold slurry through a number of mechanisms. The cold slurry can be delivered using a device in accordance with the present invention to any tissue inside the body, including subcutaneous fat, visceral fat, and brown fat.

公开(公告)号：US08536168B2

公开(公告)日：2013-09-17

申请号：US12531341

申请日：2008-03-13

Applicant: Miao Dai ,  Feng He ,  Rishi Kumar Jain ,  Rajesh Karki ,  Joseph Kelleher, III ,  John Lei ,  Luis Llamas ,  Michael A. Mcewan ,  Karen Miller-Moslin ,  Lawrence Bias Perez ,  Stefan Peukert ,  Naeem Yusuff

Inventor： Miao Dai ,  Feng He ,  Rishi Kumar Jain ,  Rajesh Karki ,  Joseph Kelleher, III ,  John Lei ,  Luis Llamas ,  Michael A. Mcewan ,  Karen Miller-Moslin ,  Lawrence Bias Perez ,  Stefan Peukert ,  Naeem Yusuff

IPC: C07D237/32 ,  C07D243/08 ,  C07D265/38 ,  A61K31/502 ,  A61K31/5377 ,  A61K31/5365 ,  A61P37/00 ,  A61P29/00

CPC classification number: C07D401/12 ,  C07D237/30 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D417/14 ,  C07D487/04 ,  C07D491/048 ,  C07D498/14 ,  C07F9/65583

Abstract: The present disclosure relates to compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders; specifically relating to compounds of formula I:

Abstract translation: 本公开内容涉及与涉及Hedgehog途径的病理学的诊断和治疗相关的化合物，包括但不限于肿瘤形成，癌症，瘤形成和非恶性过度增殖性疾病; 具体涉及式I化合物：

公开(公告)号：US20100069368A1

公开(公告)日：2010-03-18

申请号：US12531341

申请日：2008-03-13

Applicant: Miao Dai ,  Feng He ,  Rishi Kumar Jain ,  Rajesh Karki ,  Joseph Kelleher ,  John Lei ,  Luis Llamas ,  Michael A. Mcewan ,  Karen Miller-Moslin ,  Lawrence Bias Perez ,  Stefan Peukert ,  Naeem Yusuff

Inventor： Miao Dai ,  Feng He ,  Rishi Kumar Jain ,  Rajesh Karki ,  Joseph Kelleher ,  John Lei ,  Luis Llamas ,  Michael A. Mcewan ,  Karen Miller-Moslin ,  Lawrence Bias Perez ,  Stefan Peukert ,  Naeem Yusuff

IPC: A61K31/502 ,  C07D237/30 ,  C07D243/08 ,  A61K31/551 ,  A61P43/00

CPC classification number: C07D401/12 ,  C07D237/30 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D417/14 ,  C07D487/04 ,  C07D491/048 ,  C07D498/14 ,  C07F9/65583

Abstract: The present disclosure relates to compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders; specifically relating to compounds of formula I:

Abstract translation: 本公开内容涉及与涉及Hedgehog途径的病理学的诊断和治疗相关的化合物，包括但不限于肿瘤形成，癌症，瘤形成和非恶性过度增殖性疾病; 具体涉及式I化合物：

公开(公告)号：US20100055652A1

公开(公告)日：2010-03-04

申请号：US12549251

申请日：2009-08-27

Applicant: Karen Miller-Kovach ,  Ute Gerwig ,  Julia Peetz ,  Christine Jacobsohn ,  Wanema Frye ,  Stephanie Lyn Rost ,  Maria Kinirons ,  Dawn Halkuff

Inventor： Karen Miller-Kovach ,  Ute Gerwig ,  Julia Peetz ,  Christine Jacobsohn ,  Wanema Frye ,  Stephanie Lyn Rost ,  Maria Kinirons ,  Dawn Halkuff

IPC: G09B19/00 ,  G01N33/02 ,  G06Q90/00 ,  G06Q30/00 ,  G06Q50/00 ,  G06F17/30 ,  G06F15/16

CPC classification number: G09B19/0092 ,  A23L33/30 ,  A23V2002/00 ,  G01N33/02 ,  G06F19/00 ,  G06F19/3475 ,  G06Q30/0601 ,  G06Q30/0623 ,  G06Q30/0635 ,  G06Q50/10 ,  G06Q99/00 ,  G09B5/02 ,  G16H20/60 ,  G16Z99/00

Abstract: A process for controlling body weight of a consumer obtains food energy data of candidate food servings to be ingested based on an energy contribution of each of its protein content, its carbohydrate content, its dietary fiber content and its fat content and ingesting the food servings such that a sum of the food energy data thereof bears a predetermined relationship to predetermined food energy benchmark data of the consumer for a given period. Related processes for selecting and purchasing food, for producing food energy data and for producing a food product are provided. Related processes and systems for supplying food energy data to a requester and supplying meal plan data to a consumer are also provided.

Abstract translation: 用于控制消费者体重的过程基于其蛋白质含量，其碳水化合物含量，其膳食纤维含量和其脂肪含量的每种能量贡献获得待摄取的候选食物份量的食物能量数据，并摄取食物份数 其食物能量数据的总和与给定期间的消费者的预定食物能量基准数据具有预定的关系。 提供了用于选择和购买食物，用于生产食物能量数据和用于生产食品的相关过程。 还提供了用于向请求者提供食物能量数据并向消费者提供膳食计划数据的相关过程和系统。

公开(公告)号：US20100041663A1

公开(公告)日：2010-02-18

申请号：US12503565

申请日：2009-07-15

Applicant: Feng HE ,  Stefan Peukert ,  Karen Miller-Moslin ,  Naeem Yusuff ,  Zhuoliang Chen ,  Bharat Lagu

Inventor： Feng HE ,  Stefan Peukert ,  Karen Miller-Moslin ,  Naeem Yusuff ,  Zhuoliang Chen ,  Bharat Lagu

IPC: A61K31/502 ,  C07D403/14 ,  C07D237/26 ,  A61K31/501 ,  A61P35/00

CPC classification number: C07D237/20 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/501 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway.

Abstract translation: 本发明一般涉及与涉及Hedgehog途径的病理学的诊断和治疗相关的新化合物，包括但不限于肿瘤形成，癌症，瘤形成和非恶性过度增殖性疾病。 本发明包括新型化合物，新型组合物，其应用方法及其制备方法，其中这些化合物通常在药理学上可用作治疗药物，其作用机理包括使用抑制肿瘤发生的药物抑制肿瘤发生，肿瘤生长和肿瘤存活的方法 刺猬和Smo信号通路。

公开(公告)号：US20070010457A1

公开(公告)日：2007-01-11

申请号：US11522375

申请日：2006-09-14

Applicant: Anita Diu-Hercend ,  Julian Golec ,  Thierry Hercend ,  Ronald Knegtel ,  Paul Lang ,  Andrew Miller ,  Karen Miller ,  Michael Mortimore ,  Peter Weber

Inventor： Anita Diu-Hercend ,  Julian Golec ,  Thierry Hercend ,  Ronald Knegtel ,  Paul Lang ,  Andrew Miller ,  Karen Miller ,  Michael Mortimore ,  Peter Weber

IPC: A61K38/04 ,  A61K31/497 ,  A61K31/4709 ,  A61K31/454

CPC classification number: C07D401/06 ,  C07D211/60 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

Abstract: The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase and TNF-alpha activity and consequently, can be advantageously used as agents against caspase-, interleukin-1-(“IL-1”), apoptosis-, interferon-y inducing factor-(IGIF), interferon-γ-(“IFN-γ”), or TNF-alpha mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to processes for preparing the compounds of this invention. This invention also relates to methods for inhibiting caspase and TNF-alpha activity and decreasing IGIF production and IFN-γ production and methods for treating caspase-, interleukin-1, apoptosis-, and interferon-γ-, and TNF-alpha mediated diseases using the compounds and compositions of this invention.

Abstract translation: 本发明涉及新型的式I化合物，其为半胱天冬酶和TNF-α抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制半胱天冬酶和TNF-α活性，因此可有利地用作抗半胱天冬酶，白细胞介素-1（“IL-1”），细胞凋亡 - 干扰素 - γ诱导因子（IGIF），干扰素-γ-（“IFN-γ”）或TNF-α介导的疾病，包括炎性疾病，自身免疫性疾病，破坏性骨病，增殖性疾病，感染性疾病和退行性疾病。 本发明还涉及制备本发明化合物的方法。 本发明还涉及用于抑制半胱天冬酶和TNF-α活性并减少IGIF产生和IFN-γ产生的方法以及用于治疗半胱天冬酶，白细胞介素-1，细胞凋亡和干扰素γ和TNF-α介导的疾病的方法，其使用 本发明的化合物和组合物。

公开(公告)号：US08595023B2

公开(公告)日：2013-11-26

申请号：US10797284

申请日：2004-03-10

Applicant: David Kirchhoff ,  Lisa Connelly ,  Anna Crook ,  Sheila Kelly ,  Karen Miller-Kovach ,  Amie Perl ,  Palma Posillico ,  Thilo Semmelbauer ,  Amy Sheppard

Inventor： David Kirchhoff ,  Lisa Connelly ,  Anna Crook ,  Sheila Kelly ,  Karen Miller-Kovach ,  Amie Perl ,  Palma Posillico ,  Thilo Semmelbauer ,  Amy Sheppard

IPC: G06Q50/22

CPC classification number: G06F19/3475 ,  G01G19/4146 ,  G01G23/3735 ,  G01G23/3742 ,  G06F19/00 ,  G06F19/324 ,  G06Q10/109 ,  G06Q30/02 ,  G06Q30/0601 ,  G06Q50/22 ,  G06Q50/24 ,  Y10S128/921

Abstract: A weight control software system and method may provide an interactive software environment to a user via a network to enhance the ability of users to follow a weight control program. The weight control software system may generate meal plans that are automatically updated based on an updated weight of the user following the weight control program. A variety of tools may be integrated into the weight control software system and be interoperable to utilize information entered by the user or generated by the system in controlling body weight of the user. Such tools may include journal and meal planning functionality.

Abstract translation: 权重控制软件系统和方法可以经由网络向用户提供交互式软件环境，以增强用户遵循权重控制程序的能力。 权重控制软件系统可以基于权重控制程序之后的用户的更新的权重自动更新膳食计划。 各种工具可以集成到权重控制软件系统中，并且可以互操作以利用用户输入的信息或由系统产生的用于控制用户体重的信息。 这样的工具可以包括日记帐和膳食规划功能。

公开(公告)号：US08382482B2

公开(公告)日：2013-02-26

申请号：US12550240

申请日：2009-08-28

Applicant: Karen Miller-Kovach ,  Ute Gerwig ,  Julia Peetz ,  Christine Jacobsohn ,  Wanema Frye ,  Stephanie Lyn Rost ,  Maria Kinirons ,  Dawn Halkuff

Inventor： Karen Miller-Kovach ,  Ute Gerwig ,  Julia Peetz ,  Christine Jacobsohn ,  Wanema Frye ,  Stephanie Lyn Rost ,  Maria Kinirons ,  Dawn Halkuff

IPC: G09B19/00

CPC classification number: G09B19/0092 ,  A23L33/30 ,  A23V2002/00 ,  G01N33/02 ,  G06F19/00 ,  G06F19/3475 ,  G06Q30/0601 ,  G06Q30/0623 ,  G06Q30/0635 ,  G06Q50/10 ,  G06Q99/00 ,  G09B5/02 ,  G16H20/60

Abstract: Processes are provided for controlling body weight of a consumer, as well as for selecting and purchasing foods, and for producing food products, based on a combination of food energy data and relative healthfulness data for a candidate food. Various ways are provided for obtaining and accessing the food energy data and relative healthfulness data. Related processes and systems are also provided for assisting in the foregoing processes.

Abstract translation: 提供了用于控制消费者的体重，以及用于选择和购买食物以及用于生产食品的过程，其基于食物能量数据和候选食物的相对健康性数据的组合。 提供了各种方式来获取和访问食物能量数据和相对健康的数据。 还提供了相关的过程和系统以协助上述过程。

公开(公告)号：US20120315609A1

公开(公告)日：2012-12-13

申请号：US13529275

申请日：2012-06-21

Applicant: Karen Miller-Kovach ,  Ute Gerwig

Inventor： Karen Miller-Kovach ,  Ute Gerwig

IPC: G09B19/00

CPC classification number: G09B19/0092 ,  G06F19/3475 ,  G09B5/00

Abstract: A non-therapeutic method for assisting a person to control weight of the person that includes receiving, by a programmed computer system, input data, calculating, in real-time, by the programmed computer system, at least one actual RCV(t) value over a period of time based, at least in part, on the food data of the input data and stored food data; calculating, in real-time, by the programmed computer system, at least one potential RCV(t) value over a period of time; displaying, in real-time, by the programmed computer system, at least one first graphical indicator representative of the at least one actual RCV(t) value over the period of time; and displaying, in real-time, by the programmed computer system, at least one second graphical indicator representative of the at least one potential RCV(t) value over the period of time.

公开(公告)号：US20120315608A1

公开(公告)日：2012-12-13

申请号：US13493845

申请日：2012-06-11

Applicant: Karen Miller-Kovach ,  Ute Gerwig

Inventor： Karen Miller-Kovach ,  Ute Gerwig

IPC: G09B19/00

CPC classification number: G09B19/0092 ,  G06F19/3475 ,  G09B5/00

Abstract: A non-therapeutic method for assisting a person to control weight of the person that includes receiving, by a programmed computer system, input data, calculating, in real-time, by the programmed computer system, at least one actual RCV(t) value over a period of time based, at least in part, on the food data of the input data and stored food data; calculating, in real-time, by the programmed computer system, at least one potential RCV(t) value over a period of time; displaying, in real-time, by the programmed computer system, at least one first graphical indicator representative of the at least one actual RCV(t) value over the period of time; and displaying, in real-time, by the programmed computer system, at least one second graphical indicator representative of the at least one potential RCV(t) value over the period of time.

Abstract translation: 一种用于辅助人控制人的体重的非治疗方法，该方法包括由编程计算机系统接收输入数据，由编程的计算机系统实时计算至少一个实际RCV（t）值 至少部分地基于输入数据和存储的食物数据的食物数据的时间段; 通过编程的计算机系统实时计算一段时间内至少一个潜在的RCV（t）值; 实时地由编程的计算机系统显示表示该时间段内的至少一个实际RCV（t）值的至少一个第一图形指示符; 并且通过编程的计算机系统实时显示表示该时间段内的至少一个潜在RCV（t）值的至少一个第二图形指示符。