公开(公告)号：US07820700B2

公开(公告)日：2010-10-26

申请号：US11661284

申请日：2005-08-26

Applicant: Junji Miyata ,  Ryo Naito ,  Masakatsu Kawakami ,  Toru Asano

Inventor： Junji Miyata ,  Ryo Naito ,  Masakatsu Kawakami ,  Toru Asano

IPC: A61K31/4418 ,  C07D213/79

CPC classification number: C07D213/79 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: The present invention relates to a novel 2-phenylpyridine derivative or a salt thereof, wherein the pyridine ring is substituted with a carboxyl group or the like and the benzene ring has an electron-withdrawing group such as a cyano group and an electron-donating group such as a substituted alkoxy group at the same time.Since the compound of the invention has good xanthine oxidase-inhibitory action and uric acid-lowering action and does not have a structure derived from nucleic acid, the compound has advantages of high safety and excellent effects as compared with conventional compounds and is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy, or the like.

Abstract translation: 本发明涉及一种新的2-苯基吡啶衍生物或其盐，其中吡啶环被羧基等取代，苯环具有吸电子基如氰基和给电子基团 例如同时取代的烷氧基。 由于本发明的化合物具有良好的黄嘌呤氧化酶抑制作用和尿酸降低作用，并且不具有衍生自核酸的结构，与常规化合物相比，该化合物具有安全性高，效果优异的优点，可用作 高尿酸血症，痛风，炎性肠病，糖尿病性肾病，糖尿病性视网膜病变等的治疗或预防剂。

公开(公告)号：US06949543B2

公开(公告)日：2005-09-27

申请号：US10416371

申请日：2001-11-08

Applicant: Toru Kontani ,  Junji Miyata ,  Wataru Hamaguchi ,  Yoji Miyazaki ,  Hiroshi Suzuki ,  Eiichi Nakai ,  Shunji Kageyama

Inventor： Toru Kontani ,  Junji Miyata ,  Wataru Hamaguchi ,  Yoji Miyazaki ,  Hiroshi Suzuki ,  Eiichi Nakai ,  Shunji Kageyama

IPC: A61K8/42 ,  A61P31/22 ,  C07D277/40 ,  C07D277/62 ,  C07D277/64 ,  C07D277/74 ,  C07D417/12 ,  C07D417/14 ,  A61K31/426

CPC classification number: C07D277/74 ,  C07D277/40 ,  C07D277/62 ,  C07D277/64 ,  C07D417/12 ,  C07D417/14

Abstract: The invention relates to a novel amide derivative which is an N-({[4-(substituted thiazol-4-yl)phenyl]carbamoyl}methyl)amide derivative having a characteristic in that an aryl or heteroaryl group as an aromatic ring group is directly substituted on the N atom of amido group. Since said amide derivative has excellent anti-herpesvirus action, it is useful as medicaments and antiviral agents, particularly as preventive or therapeutic agents for various diseases accompanied by Herpesviridae virus infections, illustratively, varicella (chickenpox) accompanied by varicella zoster virus infection, shingles accompanied by the recurrent infection of latent varicella zoster virus, labial herpes and herpes encephalitis accompanied by HSV-1 infection, genital herpes accompanied by HSV-2 and the like various herpesvirus infections.

Abstract translation: 本发明涉及一种新颖的酰胺衍生物，其是具有芳基或杂芳基作为芳族环基的特征的N - （{[4-（取代的噻唑-4-基）苯基]氨基甲酰基}甲基） 直接取代在氨基的N原子上。 由于所述酰胺衍生物具有优异的抗疱疹病毒作用，因此可用作药物和抗病毒剂，特别是作为伴随疱疹病毒科病毒感染的各种疾病的预防或治疗剂，例如伴随水痘带状疱疹病毒感染的水痘（水痘），带状疱疹伴随 由于潜伏性水痘带状疱疹病毒的复发感染，伴有HSV-1感染的唇疱疹和疱疹性脑炎，伴有HSV-2的生殖器疱疹等各种疱疹病毒感染。

公开(公告)号：US06572003B2

公开(公告)日：2003-06-03

申请号：US09862702

申请日：2001-05-23

Applicant: Junji Miyata ,  Nobuyoshi Nakatani

Inventor： Junji Miyata ,  Nobuyoshi Nakatani

IPC: B23K114

CPC classification number: B23K11/0073 ,  B21B15/0085 ,  B23K11/061 ,  B23K2101/16

Abstract: To provide a seam welding apparatus and a seam welding method that may operate at a low pressure to obtain a suitable overlapped alignment amount. In the seam welding apparatus, a trailing plate clamp moving means is provided with link mechanisms for overlapping and aligning a leading end of a trailing plate with a trailing end of a leading plate and a link drive source for operating the link mechanisms under an extended condition. The link mechanisms are arranged in parallel along both side edges of the trailing plate. The pair of link mechanisms are connected to a link drive source to form a parallel link mechanism assembled through a coupling link. Also, a movable portion of the leading plate clamp means has a tilt pivot. This tilt pivot is adapted to be movable so that the overlapped alignment amount may be adjusted.

公开(公告)号：US5883353A

公开(公告)日：1999-03-16

申请号：US686405

申请日：1996-07-25

Applicant: Masaru Yoshida ,  Akimichi Takeda ,  Junji Miyata

Inventor： Masaru Yoshida ,  Akimichi Takeda ,  Junji Miyata

IPC: B23K11/06 ,  B23K11/16 ,  B23K11/30

CPC classification number: B23K11/3036 ,  B23K11/061

Abstract: In a welding electrode protecting machine, welding electrodes are protected against a surface treating agent on strips to be welded by applying a proper amount of electrode protecting agent onto surfaces of welding electrodes prior to or during welding operation. A seam welding machine includes a carriage (6) adapted to move in a direction orthogonal to a direction in which strips (1a, 2a) to be welded are fed, a pair of rotatable disk-like welding electrodes (8a, 8b) disposed on the carriage (6) for welding together the strips (1a, 2a) by pressing the strips (1a, 2a) to each other at surface portions thereof along which the strips are to be welded together as the carriage (6) is moved, electrode protecting agent application roll-like members (21a, 21b) for applying an electrode protecting agent (29) onto rotating surfaces of the welding electrodes (8a, 8b) while being in physical contact with the welding electrodes (8a, 8b) under pressure, the electrode protecting agent (29) which is charged from tanks (30a, 30b) by pumps (31a, 31b), and removing roll-like members (25a, 25b) disposed on the carriage for removing the electrode protecting agent (29) remaining on surface portions along which the strips (1a, 2a) to be welded were welded together at a work side relative to the welding electrodes (8a, 8b).

Abstract translation: 在焊接电极保护机中，在焊接操作之前或焊接操作期间，通过在焊接电极的表面上施加适当量的电极保护剂，焊接电极被保护成待焊接的条上的表面处理剂。 缝焊机包括：托架（6），其适于在与要被焊接的条带（1a，2a）的方向正交的方向上移动;一对可旋转的盘状焊接电极（8a，8b） 用于通过在滑架（6）移动时将条带焊接在一起的表面部分处将条带（1a，2a）彼此压合在一起来将条带（1a，2a）焊接在一起的托架（6） 用于在与焊接电极（8a，8b）物理接触的同时在电极（8a，8b）的旋转表面上施加电极保护剂（29）的保护剂施用辊状构件（21a，21b） 通过泵（31a，31b）从罐（30a，30b）装载的电极保护剂（29）和除去设置在滑架上的用于除去电极保护剂（29）的辊状构件（25a，25b） 在被焊接的条（1a，2a）焊接在一起的表面部分a上 相对于焊接电极（8a，8b）的工作侧。

公开(公告)号：US5185240A

公开(公告)日：1993-02-09

申请号：US565083

申请日：1990-08-10

Applicant: Junji Miyata ,  Satoshi Kanetake ,  Yasufumi Morimoto ,  Kenji Hanayama

Inventor： Junji Miyata ,  Satoshi Kanetake ,  Yasufumi Morimoto ,  Kenji Hanayama

IPC: G03C1/34 ,  G03C1/485

CPC classification number: G03C1/34 ,  G03C1/48515 ,  Y10S430/141

Abstract: Disclosed is an autopositive silver halide photographic material which comprises at least one silver halide emulsion layer, characterized in that said emulsion layer or at least one other hydrophilic colloid layers contains at least one compound selected from the group consisting of compounds represented by the following general formulas (1), (2) and (3): ##STR1## wherein R.sub.1 represents hydrogen atom or an alkyl group; and R.sub.2, R.sub.3 and R.sub.4 each represents hydrogen atom, a halogen atom, an alkyl group or an alkoxy group; ##STR2## wherein R.sub.5 represents hydrogen atom or an alkyl group; and R.sub.6 and R.sub.7 each represents hydrogen atom, an alkyl group, a halogen atom or an aryl group; ##STR3## wherein R.sub.8 represents a lower alkylene group; X represents a halogen atom, nitro group, hydroxy group, a cyano group, a lower alkyl group, a lower alkoxy group, ##STR4## or --SO.sub.3 M; R.sub.12 represents hydrogen atom, --OM, a lower alkyl group, a lower alkoxy group or ##STR5## R.sub.13 and R.sub.14 may be the same or different groups and each represents hydrogen atom, a lower alkyl group, --COR.sub.17 or --SO.sub.2 R.sub.17 ; R.sub.15 and R.sub.16 may be the same or different groups and each represents hydrogen atom or a lower alkyl group; R.sub.17 represents a lower alkyl group; M represents hydrogen atom, an alkali metal or an atomic group required for forming a monovalent cation; and n represents 0 or an integer of 1 to 5.

Abstract translation: 公开了一种自动正卤化银照相材料，其包含至少一种卤化银乳剂层，其特征在于，所述乳剂层或至少一种其它亲水胶体层含有至少一种选自由以下通式表示的化合物 （1），（2）和（3）：其中R 1表示氢原子或烷基; R2，R3和R4各自表示氢原子，卤素原子，烷基或烷氧基; （2）其中R5表示氢原子或烷基; R6和R7各自表示氢原子，烷基，卤原子或芳基; （3）其中R8表示低级亚烷基; X表示卤原子，硝基，羟基，氰基，低级烷基，低级烷氧基，或者-SO 3 M; R 12表示氢原子，-OM，低级烷基，低级烷氧基或R 13和R 14可以相同或不同，各自表示氢原子，低级烷基，-COR 17或-SO 2 R 17; R 15和R 16可以相同或不同，各自表示氢原子或低级烷基; R 17表示低级烷基; M表示氢原子，形成一价阳离子所需的碱金属或原子团; n表示0或1〜5的整数。

公开(公告)号：US4903469A

公开(公告)日：1990-02-27

申请号：US109347

申请日：1987-10-16

Applicant: Masatake Murakawa ,  Niro Bando ,  Masatsugu Tone ,  Mikio Yuki ,  Junji Miyata ,  Tetsuaki Hayashi ,  Kazuaki Kurohara

Inventor： Masatake Murakawa ,  Niro Bando ,  Masatsugu Tone ,  Mikio Yuki ,  Junji Miyata ,  Tetsuaki Hayashi ,  Kazuaki Kurohara

IPC: A01D34/63 ,  A01D43/063 ,  A01D34/70

CPC classification number: A01D43/063 ,  A01D2101/00 ,  A01D34/63

Abstract: A lawn mower comprising a cutting unit disposed between front and rear wheels, a grass discharge duct extending rearwardly from the cutting unit, and a grass collecting container defining a top opening for receiving grass clippings sent through the discharge duct. The grass collecting container includes a mouthpiece extending along peripheries of the top opening to rest on a U-shaped support frame mounted at a rear end of the mower. The mouthpiece is connected to the support frame by a projection and bore engagement. The support frame includes a holder defining an upwardly opening recess, and the container has a cover defining a downwardly opening recess at a position opposed to the holder. The two recesses define an opening for receiving a rear end of the grass discharge duct. The grass discharge duct includes an annular engagement portion extending peripherally of the rear end thereof for engagement with inner edges of the two recesses.

Abstract translation: 一种割草机，包括设置在前轮和后轮之间的切割单元，从切割单元向后延伸的草排出管，以及限定用于接收通过排出管送出的草屑的顶部开口的草收集容器。 草收集容器包括沿着顶部开口的周边延伸的接口，以便搁置在安装在割草机后端的U形支撑框架上。 接口通过突出和孔接合连接到支撑框架。 支撑框架包括限定向上开口的凹部的保持器，并且容器具有在与保持器相对的位置处限定向下开口的凹部的盖。 两个凹部限定用于接收草排出管道的后端的开口。 草排出管道包括在其后端的周边延伸的环形接合部分，用于与两个凹部的内边缘接合。

公开(公告)号：US4725532A

公开(公告)日：1988-02-16

申请号：US824038

申请日：1986-01-30

Applicant: Kimitaka Kameoka ,  Junji Miyata ,  Masaki Okazaki ,  Senzo Sasaoka

Inventor： Kimitaka Kameoka ,  Junji Miyata ,  Masaki Okazaki ,  Senzo Sasaoka

IPC: G03C1/06 ,  G03C1/12 ,  G03C1/14 ,  G03C1/16 ,  G03C1/18 ,  G03C1/26 ,  G03C1/02

CPC classification number: G03C1/12 ,  G03C1/061 ,  G03C1/127 ,  G03C1/14 ,  G03C1/16 ,  G03C1/18 ,  G03C1/26

Abstract: A silver halide photographic light-sensitive material and high contrast negative image forming process using them are disclosed. The material comprises a support having thereon at least one silver halide emulsion layer in which said silver halide emulsion layer or other hydrophilic colloid layer contains at least one hydrazine derivative, at least one cationic dye selected from a cyanine dye, a hemicyanine dye and a rhodacyanine dye, and L-ascorbic acid, and has photographic characteristics of giving very high contrast of over 10 in .gamma., giving high practical Dmax and sensitivity, and causing less black peppers using a stable developer and having optimum spectral sensitivity for spectral energy distributions of various light sources.

Abstract translation: 公开了一种卤化银照相感光材料和使用它们的高对比度负成像方法。 该材料包括其上具有至少一个卤化银乳剂层的载体，其中所述卤化银乳剂层或其它亲水胶体层含有至少一种肼衍生物，至少一种阳离子染料，其选自花青染料，半花青染料和若丹西酸 染料和L-抗坏血酸，并且具有给予非常高的对比度的10倍以上的伽马射线特性，具有高实用的Dmax和灵敏度，并且使用稳定的显影剂引起较少的黑胡椒并且对各种光谱能量分布具有最佳光谱灵敏度 光源。

公开(公告)号：US4268056A

公开(公告)日：1981-05-19

申请号：US66744

申请日：1979-08-15

Applicant: Junji Miyata ,  Kazuaki Kurohara

Inventor： Junji Miyata ,  Kazuaki Kurohara

IPC: A01B59/041 ,  A01B59/042 ,  A01B59/043 ,  B60D1/01 ,  B60D1/14

CPC classification number: A01B59/042 ,  B60D1/141

Abstract: A structure for attaching a hitch to a tractor for detachably connecting a trailing working device to the tractor. A rod for pivotably supporting a pair of opposed lower links for connecting a ground working implement to the tractor pivotally movably up and down is supported by and extends transversely through a transmission case portion. The hitch is supported on the rod.

Abstract translation: 用于将牵引装置连接到拖拉机以将拖尾工作装置可拆卸地连接到拖拉机的结构。 用于可枢转地支撑用于将地面工作工具连接到拖拉机的一对相对的下连杆的杆可枢转地上下移动地支撑并横向延伸穿过变速箱部分。 挂钩支撑在杆上。

公开(公告)号：US4245518A

公开(公告)日：1981-01-20

申请号：US944430

申请日：1978-09-21

Applicant: Kazuo Toyokuni ,  Junji Miyata ,  Hiroshi Itatani ,  Ryozo Kuroiwa

Inventor： Kazuo Toyokuni ,  Junji Miyata ,  Hiroshi Itatani ,  Ryozo Kuroiwa

IPC: A01B33/08 ,  F16H7/08

CPC classification number: F16H7/08 ,  F16H2007/0891 ,  F16H2007/0893

Abstract: A device for tightening an endless element which is trained over driving members and which is accommodated in a drive transmission housing. A regulation member is provided outside the housing for easy adjustment of the tautness or tension of the endless element.

Abstract translation: 一种用于紧固环形元件的装置，其被训练在驱动构件上并且容纳在驱动变速器壳体中。 调节构件设置在壳体外部，以便于调节环形元件的紧张度或紧张度。

公开(公告)号：US07084164B2

公开(公告)日：2006-08-01

申请号：US11232011

申请日：2005-09-22

Applicant: Takahiko Tobe ,  Takashi Sugane ,  Wataru Hamaguchi ,  Itsuro Shimada ,  Kyoichi Maeno ,  Junji Miyata ,  Tetsuya Kimizuka ,  Takeshi Suzuki ,  Atsuyuki Kohara ,  Takuma Morita ,  Michael Arlt ,  Hartmut Greiner

Inventor： Takahiko Tobe ,  Takashi Sugane ,  Wataru Hamaguchi ,  Itsuro Shimada ,  Kyoichi Maeno ,  Junji Miyata ,  Tetsuya Kimizuka ,  Takeshi Suzuki ,  Atsuyuki Kohara ,  Takuma Morita ,  Michael Arlt ,  Hartmut Greiner

IPC: A61K31/41 ,  C07D249/08

CPC classification number: C07D249/08 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/517 ,  A61K31/5377 ,  C07D249/10 ,  C07D249/12 ,  C07D249/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/10 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D495/04

Abstract: The invention relates to a triazole derivative with an activity inhibiting glycine transporter and for use as a pharmaceutical drug, and a novel triazole derivative. The inventive triazole derivative has an excellent activity inhibiting glycine transporter and is useful as a therapeutic agent of dementia, schizophrenia, cognitive disorders, or cognitive disorders involved in various diseases such as Alzheimer disease, Parkinson's disease, or Huntington disease or the like, or spasm involved in diseases such as nerve degenerative diseases and cerebrovascular disorders, or the like. Particularly, the pharmaceutical drug is useful for the amelioration of learning disability of dementia and the like.