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    Ultrasound target vessel occlusion using microbubbles
    2.
    发明授权
    Ultrasound target vessel occlusion using microbubbles 有权
    使用微泡的超声靶标血管闭塞

    公开(公告)号：US07591996B2

    公开(公告)日：2009-09-22

    申请号：US11206639

    申请日：2005-08-17

    Applicant: Joo Ha Hwang ,  Andrew Brayman

    Inventor： Joo Ha Hwang ,  Andrew Brayman

    IPC: A61B17/26 ,  A61B8/00 ,  A61B8/12 ,  A61K38/00

    CPC classification number: A61N7/02 ,  A61B8/0833 ,  A61B2017/22008 ,  A61K38/363 ,  A61M2025/109

    Abstract: Selective occlusion of a blood vessel is achieved by selectively damaging endothelial cells at a target location in the blood vessel, resulting in the formation of a fibrin clot proximate to the damaged endothelial cells. Additional fibrinogen can then be introduced into the blood vessel if occlusion is not achieved, as the fibrinogen is converted to fibrin by enzymes released by the exposed thrombogenic tissue and activated platelets. Endothelial cells are selectively damaged using thermal effects induced by ultrasound, by mechanical effects induced by ultrasound, or by mechanical effects produced by a tool introduced into the blood vessel (such as a catheter-based tool). A particularly preferred technique for selectively damaging endothelial cells involves introducing an ultrasound activatable agent into the blood vessel, and causing cavitation in that agent using pulses of high-intensity focused ultrasound having a duration insufficient to induce thermal damage in adjacent perivascular tissue.

    Abstract translation: 血管的选择性闭塞通过选择性地损伤血管中目标位置处的内皮细胞来实现，导致在损伤的内皮细胞附近形成纤维蛋白凝块。 然后如果没有实现闭塞，则可以将额外的纤维蛋白原引入血管，因为通过暴露的血栓形成组织和活化的血小板释放的酶将纤维蛋白原转化为纤维蛋白。 使用由超声诱导的热效应，由超声诱导的机械效应或通过引入血管的工具（例如基于导管的工具）产生的机械效应来选择性地损伤内皮细胞。 用于选择性损伤内皮细胞的特别优选的技术包括将超声可激活剂引入血管中，并且使用具有不足以在相邻血管周围组织中引起热损伤的持续时间的高强度聚焦超声的脉冲引起该药剂中的空化。

    HIGH RESOLUTION OPTICAL COHERENCE TOMOGRAPHY BASED IMAGING FOR INTRALUMINAL AND INTERSTITIAL USE IMPLEMENTED WITH A REDUCED FORM FACTOR
    4.
    发明申请
    HIGH RESOLUTION OPTICAL COHERENCE TOMOGRAPHY BASED IMAGING FOR INTRALUMINAL AND INTERSTITIAL USE IMPLEMENTED WITH A REDUCED FORM FACTOR 有权
    高分辨光学相干基于图像的成像，用于减少形式因子实现的内脏和间质使用

    公开(公告)号：US20090323076A1

    公开(公告)日：2009-12-31

    申请号：US12114281

    申请日：2008-05-02

    Applicant: Xingde Li ,  Xiumei Liu ,  Joo Ha Hwang

    Inventor： Xingde Li ,  Xiumei Liu ,  Joo Ha Hwang

    IPC: G01B9/02

    CPC classification number: G01B9/0205 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/65 ,  G01N21/4795

    Abstract: Mechanically robust minimal form factor OCT probes suitable for medical applications such as needle biopsy, intraluminal and intravascular imaging are achieved in part by employing compound lenses with some or all of the optical elements, including an optical fiber, to be thermally fused in tandem. To achieve a desired working distance without increasing a diameter of the optics assembly, a spacer can be disposed between the optical fiber and focusing optics. The compound lens configuration can achieve higher transverse resolution compared to a single lens at a desired working distance without increasing the probe diameter. In exemplary needle biopsy embodiments, the optical assembly is encapsulated in a glass housing or metal-like housing with a glass window, which is then selectively passed through a hollow needle. Esophageal imaging embodiments are combined with a balloon catheter. Circumferential and three-dimensional spiral scanning can be achieved in each embodiment.

    Abstract translation: 适用于医疗应用如针刺活检，腔内和血管内成像的机械稳健的最小形状因子部分通过采用复合透镜来实现，其中部分或全部光学元件（包括光纤）被串联热熔合。 为了在不增加光学组件的直径的情况下实现期望的工作距离，可以在光纤和聚焦光学器件之间设置隔离物。 复合透镜配置可以在不增加探针直径的情况下，在单个透镜的期望工作距离下实现更高的横向分辨率。 在示例性针活检实施例中，光学组件被封装在具有玻璃窗的玻璃外壳或金属状外壳中，然后玻璃窗选择性地穿过中空针。 食管成像实施例与气囊导管组合。 在各实施例中可以实现圆周和三维螺旋扫描。

    High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor
    5.
    发明授权
    High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor 有权
    高分辨率光学相干断层扫描成像用于腔内和间质用途，实现减小的形状因子

    公开(公告)号：US07952718B2

    公开(公告)日：2011-05-31

    申请号：US12114281

    申请日：2008-05-02

    Applicant: Xingde Li ,  Xiumei Liu ,  Joo Ha Hwang

    Inventor： Xingde Li ,  Xiumei Liu ,  Joo Ha Hwang

    IPC: G01B9/02

    CPC classification number: G01B9/0205 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/65 ,  G01N21/4795

    Abstract: Mechanically robust minimal form factor OCT probes suitable for medical applications such as needle biopsy, intraluminal and intravascular imaging are achieved in part by employing compound lenses with some or all of the optical elements, including an optical fiber, to be thermally fused in tandem. To achieve a desired working distance without increasing a diameter of the optics assembly, a spacer can be disposed between the optical fiber and focusing optics. The compound lens configuration can achieve higher transverse resolution compared to a single lens at a desired working distance without increasing the probe diameter. In exemplary needle biopsy embodiments, the optical assembly is encapsulated in a glass housing or metal-like housing with a glass window, which is then selectively passed through a hollow needle. Esophageal imaging embodiments are combined with a balloon catheter. Circumferential and three-dimensional spiral scanning can be achieved in each embodiment.

    Abstract translation: 适用于医疗应用如针刺活检，腔内和血管内成像的机械稳健的最小形状因子部分通过采用复合透镜来实现，其中部分或全部光学元件（包括光纤）被串联热熔合。 为了在不增加光学组件的直径的情况下实现期望的工作距离，可以在光纤和聚焦光学器件之间设置隔离物。 复合透镜配置可以在不增加探针直径的情况下，在单个透镜的期望工作距离下实现更高的横向分辨率。 在示例性针活检实施例中，光学组件被封装在具有玻璃窗的玻璃外壳或金属状外壳中，然后玻璃窗选择性地穿过中空针。 食管成像实施例与气囊导管组合。 在各实施例中可以实现圆周和三维螺旋扫描。

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