公开(公告)号：US20170071515A1

公开(公告)日：2017-03-16

申请号：US15122394

申请日：2015-04-02

Applicant: John R. Chevillet ,  Tatiana D. Khokhlova ,  George R. Schade ,  Joo Ha Hwang ,  Muneesh Tewari

Inventor： John R. Chevillet ,  Tatiana D. Khokhlova ,  George R. Schade ,  Joo Ha Hwang ,  Muneesh Tewari

IPC: A61B5/145 ,  A61N7/02 ,  A61B5/15 ,  A61B5/00 ,  A61B10/00

CPC classification number: A61B5/14546 ,  A61B5/145 ,  A61B5/14507 ,  A61B5/15 ,  A61B5/4836 ,  A61B8/08 ,  A61B8/5223 ,  A61B10/0038 ,  A61B10/007 ,  A61B2010/0077 ,  A61N7/02 ,  A61N7/022 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: The present disclosure provides methods of performing a liquid molecular biopsy on a subject using high intensity focused ultrasound (HIFU) energy. The present disclosure also provides methods of diagnosing a disease or a risk of a disease, such as a cancer, in a subject. The present disclosure further provides methods of treating one or more tissue masses (e.g., nodules, tumors, cysts, lesions, cells of unknown significance etc.) in a subject. In some embodiments, the methods are non-invasive or minimally invasive.

Abstract translation: 本公开提供了使用高强度聚焦超声（HIFU）能量对受试者进行液体分子活检的方法。 本公开还提供了在受试者中诊断疾病或诸如癌症的疾病的风险的方法。 本公开进一步提供了在受试者中治疗一种或多种组织块（例如结节，肿瘤，囊肿，损伤，细胞等等等）的方法。 在一些实施方案中，所述方法是非侵入性的或微创的。

公开(公告)号：US20110144139A1

公开(公告)日：2011-06-16

申请号：US12997465

申请日：2009-05-21

Applicant: Valeri I. Vasioukhin ,  John R. Chevillet

Inventor： Valeri I. Vasioukhin ,  John R. Chevillet

IPC: A61K31/517 ,  A61K31/435 ,  C12N9/99 ,  A61P35/00 ,  A61P35/04

CPC classification number: G01N33/574 ,  A61K31/343 ,  A61K31/40 ,  A61K31/433 ,  A61K31/473 ,  A61K31/506 ,  A61K31/536 ,  A61K49/0004 ,  A61K49/0017 ,  A61K51/00 ,  C12N9/99

Abstract: Compositions and methods are provided for preventing or attenuating cancer progression or blocking metastasis in prostate cancer and other cancers (e.g., ovarian carcinoma, endometrial cancer, renal cell carcinoma) that are characterized by overexpression of the type II cell surface serine protease hepsin, based on the discovery of multiple disclosed compounds having activity as specific hepsin inhibitors.

Abstract translation: 提供了组合物和方法，用于预防或减弱前列腺癌和其他癌症（例如卵巢癌，子宫内膜癌，肾细胞癌）中的癌症进展或阻滞转移，其特征在于II型细胞表面丝氨酸蛋白酶hepin的过表达，基于 发现具有作为特异性hepsin抑制剂的活性的多种公开的化合物。

公开(公告)号：US08450334B2

公开(公告)日：2013-05-28

申请号：US12997465

申请日：2009-05-21

Applicant: Valeri I. Vasioukhin ,  John R. Chevillet

Inventor： Valeri I. Vasioukhin ,  John R. Chevillet

IPC: A61K31/517 ,  A61K31/435 ,  C12N9/99 ,  A61P35/00 ,  A61P35/04

CPC classification number: G01N33/574 ,  A61K31/343 ,  A61K31/40 ,  A61K31/433 ,  A61K31/473 ,  A61K31/506 ,  A61K31/536 ,  A61K49/0004 ,  A61K49/0017 ,  A61K51/00 ,  C12N9/99

Abstract: Compositions and methods are provided for preventing or attenuating cancer progression or blocking metastasis in prostate cancer and other cancers (e.g., ovarian carcinoma, endometrial cancer, renal cell carcinoma) that are characterized by overexpression of the type II cell surface serine protease hepsin, based on the discovery of multiple disclosed compounds having activity as specific hepsin inhibitors.