公开(公告)号：US20130225655A1

公开(公告)日：2013-08-29

申请号：US13695073

申请日：2011-05-04

申请人： Patrick Y. Lu ,  Vera Simonenko ,  David Evans ,  John J. Xu

发明人： Patrick Y. Lu ,  Vera Simonenko ,  David Evans ,  John J. Xu

IPC分类号： A61K31/713 ,  C07H21/02 ,  A61K45/06

CPC分类号： A61K31/713 ,  A61K45/06 ,  C07H21/02 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/11 ,  C12N2320/31 ,  C12Y114/99001

摘要： The present invention provides compositions and methods for using combinations of TGFβ1 and Cox-2 inhibitors and TGFβ1 and Hoxb13 inhibitors for the treatment of various medical conditions, including skin scaring due to trauma wounds and surgery, corneal and retina scaring due to injury and surgery, internal organ scaring due to injury and surgery, heart tissue scaring due to heart attack and surgery, and lung, liver, and kidney fibrosis due to inflammation and injury. One example is to use siRNA inhibitors to silence TGFβ1 and Cox-2 at the same time, resulting in significant less scar formation.

摘要翻译： 本发明提供了使用TGFbeta1和Cox-2抑制剂和TGFbeta1和Hoxb13抑制剂的组合的组合物和方法，用于治疗各种医疗状况，包括由创伤伤口和手术引起的皮肤灼伤，由于损伤和手术引起的角膜和视网膜的惊吓， 由于受伤和手术引起的内部器官惊吓，心脏病发作和手术引起的心脏组织惊厥，以及炎症和损伤引起的肺，肝，肾纤维化。 一个实例是使用siRNA抑制剂同时沉默TGFbeta1和Cox-2，导致显着较少的瘢痕形成。

公开(公告)号：US20130345284A1

公开(公告)日：2013-12-26

申请号：US13752568

申请日：2013-01-29

申请人： Alan Y. Lu ,  Patrick Y. Lu ,  David M. Evans ,  John J. Xu

发明人： Alan Y. Lu ,  Patrick Y. Lu ,  David M. Evans ,  John J. Xu

IPC分类号： C12N15/113

CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2320/31

摘要： The invention provides siRNA compositions that (1) interfere with viral replication of human papillomavirus (HPV), herpes simplex virus (HSV), and human immunodeficiency virus (HIV) in mucosal tissues, such as genital tissues, and (2) treat fungal infections. The compositions include siRNA molecules that target HPV, complexed with a dendrimer that treats and prevents genital herpes (HSV) and HIV. The compositions also include siRNA molecules that target HPV, complexed with a histidine-lysine (HK) polymer that treats and prevent fungus infection. The combined formulations of siRNA and dendrimer provide treatment of the infections from HPVs, HSVs, and HIVs. The combined formulations of siRNA and HK polymer provide treatment of HPVs and fungus infections.

摘要翻译： 本发明提供了siRNA组合物，其（1）干扰人乳头状瘤病毒（HPV），单纯疱疹病毒（HSV）和人类免疫缺陷病毒（HIV）在粘膜组织如生殖器官组织中的病毒复制，和（2）治疗真菌感染 。 组合物包括靶向HPV的siRNA分子，与治疗和预防生殖器疱疹（HSV）和HIV的树突状细胞复合。 组合物还包括靶向HPV的siRNA分子，与治疗和预防真菌感染的组氨酸 - 赖氨酸（HK）聚合物复合。 siRNA和树枝状大分子的组合制剂提供了对HPV，HSV和HIV感染的治疗。 siRNA和HK聚合物的组合制剂提供对HPV和真菌感染的治疗。

公开(公告)号：US20130123330A1

公开(公告)日：2013-05-16

申请号：US13549514

申请日：2012-07-15

申请人： Patrick Y. Lu ,  John J. Xu ,  Alan Y. Lu

发明人： Patrick Y. Lu ,  John J. Xu ,  Alan Y. Lu

IPC分类号： A61K31/713

CPC分类号： A61K31/713 ,  A61K2300/00

摘要： The present invention relates to compositions and methods for treating diabetic retinopathy and other ocular neovascularization diseases. In one embodiment, the composition comprises at least two different siRNA duplexes and a pharmaceutically acceptable carrier. One of the duplexes binds to an mRNA molecule that encodes VEGF, and the other binds to an mRNA molecule that encodes VEGFR2. In another embodiment, the composition further comprises an siRNA duplex that binds to an mRNA molecule that encodes TGFβ1.

摘要翻译： 本发明涉及用于治疗糖尿病性视网膜病变和其它眼部新血管形成疾病的组合物和方法。 在一个实施方案中，组合物包含至少两种不同的siRNA双链体和药学上可接受的载体。 双链体之一与编码VEGF的mRNA分子结合，另一个与编码VEGFR2的mRNA分子结合。 在另一个实施方案中，组合物还包含与编码TGFbeta1的mRNA分子结合的siRNA双链体。

公开(公告)号：US09642873B2

公开(公告)日：2017-05-09

申请号：US13695073

申请日：2011-05-04

申请人： Patrick Y. Lu ,  Vera Simonenko ,  David Evans ,  John J. Xu

发明人： Patrick Y. Lu ,  Vera Simonenko ,  David Evans ,  John J. Xu

IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K48/00 ,  A61K31/713 ,  C12N15/113 ,  A61K45/06

CPC分类号： A61K31/713 ,  A61K45/06 ,  C07H21/02 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/11 ,  C12N2320/31 ,  C12Y114/99001

摘要： The present invention provides compositions and methods for using combinations of TGFβ1 and Cox-2 inhibitors and TGFβ1 and Hoxb13 inhibitors for the treatment of various medical conditions, including skin scaring due to trauma wounds and surgery, corneal and retina scaring due to injury and surgery, internal organ scaring due to injury and surgery, heart tissue scaring due to heart attack and surgery, and lung, liver, and kidney fibrosis due to inflammation and injury. One example is to use siRNA inhibitors to silence TGFβ1 and Cox-2 at the same time, resulting in significant less scar formation.

公开(公告)号：US09506063B2

公开(公告)日：2016-11-29

申请号：US13752568

申请日：2013-01-29

申请人： Alan Y. Lu ,  Patrick Y. Lu ,  David M. Evans ,  John J. Xu

发明人： Alan Y. Lu ,  Patrick Y. Lu ,  David M. Evans ,  John J. Xu

IPC分类号： C12N15/113

CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2320/31

摘要： The invention provides siRNA compositions that (1) interfere with viral replication of human papillomavirus (HPV), herpes simplex virus (HSV), and human immunodeficiency virus (HIV) in mucosal tissues, such as genital tissues, and (2) treat fungal infections. The compositions include siRNA molecules that target HPV, complexed with a dendrimer that treats and prevents genital herpes (HSV) and HIV. The compositions also include siRNA molecules that target HPV, complexed with a histidine-lysine (HK) polymer that treats and prevent fungus infection. The combined formulations of siRNA and dendrimer provide treatment of the infections from HPVs, HSVs, and HIVs. The combined formulations of siRNA and HK polymer provide treatment of HPVs and fungus infections.

摘要翻译： 本发明提供了siRNA组合物，其（1）干扰人乳头状瘤病毒（HPV），单纯疱疹病毒（HSV）和人类免疫缺陷病毒（HIV）在粘膜组织如生殖器官组织中的病毒复制，和（2）治疗真菌感染 。 组合物包括靶向HPV的siRNA分子，与治疗和预防生殖器疱疹（HSV）和HIV的树突状细胞复合。 组合物还包括靶向HPV的siRNA分子，与治疗和预防真菌感染的组氨酸 - 赖氨酸（HK）聚合物复合。 siRNA和树枝状大分子的组合制剂提供了对HPV，HSV和HIV感染的治疗。 siRNA和HK聚合物的组合制剂提供对HPV和真菌感染的治疗。