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公开(公告)号：US08992904B2
公开(公告)日：2015-03-31
申请号：US13511385
申请日：2010-11-24
IPC分类号： A61K39/395 , C07K16/24 , A61K38/20 , A61K31/454 , A61K39/00
摘要： The present invention is directed to therapeutic methods and compositions, especially subcutaneous and intravenous composition using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved.
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公开(公告)号：US20140271664A1
公开(公告)日：2014-09-18
申请号：US13803768
申请日：2013-03-14
申请人： Leon F. Garcia-Martinez , Andrew Lawrence Feldhaus , Katherine Olson , Benjamin H. Dutzar , John A. Latham
发明人： Leon F. Garcia-Martinez , Andrew Lawrence Feldhaus , Katherine Olson , Benjamin H. Dutzar , John A. Latham
IPC分类号： C07K16/22 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K2317/14 , C07K2317/30 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention is directed to antibodies and fragments thereof (especially chimeric and humanized) having binding specificity for HGF and their use in therapy and diagnosis. These antibodies inhibit or block HGF-associated activities including HGF's effects on cell proliferation, invasion, angiogenesis, metastasis and fibrosis. Particularly the antibodies may be used as a monotherapy or in combination therapies in treating cancer, other proliferative disorders and other conditions wherein inhibition of HGF and/or the HGF/HGF-R (c-met) interaction is desired.
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公开(公告)号：US09724410B2
公开(公告)日：2017-08-08
申请号：US13511385
申请日：2010-11-24
IPC分类号： A61K39/395 , C07K16/24 , A61K38/20 , A61K31/454 , A61K45/06 , C07K16/46 , A61K39/00
CPC分类号： A61K39/3955 , A61K31/454 , A61K38/2013 , A61K38/208 , A61K45/06 , A61K49/0004 , A61K49/0058 , A61K51/1033 , A61K2039/505 , A61K2039/545 , C07K16/248 , C07K16/462 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , G01N33/6863 , Y02A50/412 , Y02A50/58
摘要： The present invention is directed to therapeutic methods and compositions, especially subcutaneous and intravenous composition using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved.
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4.发明申请ANTAGONISTS OF IL-6 TO PREVENT OR TREAT CACHEXIA, WEAKNESS, FATIGUE , AND/OR FEVER 有权IL-6的拮抗作用可以预防或治疗慢性病，脆弱性，疲劳和/或感染公开(公告)号：US20130183293A1
公开(公告)日：2013-07-18
申请号：US13681501
申请日：2012-11-20
IPC分类号： C07K16/24 , A61K39/395 , A61K45/06
CPC分类号： C07K16/248 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K2317/34 , C07K2317/76 , C07K2317/92 , Y02A50/412
摘要： The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved.
摘要翻译： 本发明涉及使用具有IL-6结合特异性的抗体及其片段以预防或治疗有需要的患者的恶病质，发热，乏力和/或疲劳的治疗方法。 在优选的实施方案中，抗IL-6抗体将被人源化和/或将被糖基化。 此外，在优选实施方案中，这些患者将包括显示升高的血清C-反应蛋白水平（或处于发展中的风险）的那些。 在另一个优选实施例中，优选地改善患者的生存性或生活质量。
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5.发明申请METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES THAT SELECTIVELY INHIBIT THE ASSOCIATION OF NGF WITH TRKA, WITHOUT AFFECTING THE ASSOCIATION OF NGF WITH P75 有权使用抗NGF抗体预防或治疗疼痛的方法，选择性地抑制NGF与TRKA的结合，而不影响NGF与P75的关联公开(公告)号：US20120164067A1
公开(公告)日：2012-06-28
申请号：US13308665
申请日：2011-12-01
申请人： John A. Latham , Ethan W. Ojala , Jeffrey T.L. Smith , Benjamin H. Dutzar , Leon F. Garcia-Martinez
发明人： John A. Latham , Ethan W. Ojala , Jeffrey T.L. Smith , Benjamin H. Dutzar , Leon F. Garcia-Martinez
IPC分类号： A61K51/10 , A61K38/02 , A61K38/18 , A61K31/7105 , A61P29/00 , A61P19/00 , A61P15/00 , A61P1/18 , A61P1/00 , A61P25/00 , A61P25/06 , A61P27/02 , A61P17/00 , A61K38/45 , A61K31/713 , A61P31/04 , A61P37/08 , A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K51/1021 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/466
摘要： NGF antagonists including antibodies and antibody fragments thereof having binding specificity to human Nerve Growth Factor (“NGF”), and methods of treating pain. Methods of treating pain or eliciting an analgesic effect in an individual comprising administering an effective amount of an NGF antagonist inhibits the association of NGF with TrkA without inhibiting the association of NGF with p75. The methods may further comprise administering an effective amount of a second anti-human NGF antibody or fragment thereof which inhibits the association of NGF with p75, that may further also inhibit the association of NGF with TrkA.
摘要翻译： 包括对人神经生长因子（“NGF”）具有结合特异性的抗体及其抗体片段的NGF拮抗剂和治疗疼痛的方法。 在个体中治疗疼痛或引起镇痛作用的方法包括施用有效量的NGF拮抗剂抑制NGF与TrkA的缔合，而不抑制NGF与p75的结合。 所述方法可以进一步包括施用有效量的抑制NGF与p75缔合的第二抗人NGF抗体或其片段，其还可以抑制NGF与TrkA的缔合。
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公开(公告)号：US07628314B2
公开(公告)日：2009-12-08
申请号：US11495105
申请日：2006-07-28
摘要： A gable top container for storing an item is provided. The gable top container has a bottom made from at least one bottom forming panel. A side is formed from at least one side forming panel that extends from the bottom. A pair of gusset panels and a pair of gable panels extend from the side. The gable panels are arranged with respect to the gusset panels to form a gable top. Each of the gable panels has a fin that defines perforations that allow for the removal of at least a portion of the fin in order to effect opening of the container from one end of the gable panels to an opposite end of the gable panels. The container may be opened in order for a fork or spoon to be used in order to remove contents therefrom.
摘要翻译： 提供了用于存储物品的山形顶部容器。 山形顶部容器具有由至少一个底部形成板制成的底部。 一侧由从底部延伸的至少一个侧面成形板形成。 一对角撑板和一对山墙板从侧面延伸。 山墙面板相对于角撑板布置以形成山墙顶部。 每个山墙板具有鳍，其限定穿孔，其允许去除鳍的至少一部分，以便将容器从山墙板的一端打开到山墙板的相对端。 为了从其中除去内容物，可以打开容器以便使用叉子或勺子。
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公开(公告)号：US20080023534A1
公开(公告)日：2008-01-31
申请号：US11495105
申请日：2006-07-28
IPC分类号： B65D5/72
摘要： A gable top container for storing an item is provided. The gable top container has a bottom made from at least one bottom forming panel. A side is formed from at least one side forming panel that extends from the bottom. A pair of gusset panels and a pair of gable panels extend from the side. The gable panels are arranged with respect to the gusset panels to form a gable top. Each of the gable panels has a fin that defines perforations that allow for the removal of at least a portion of the fin in order to effect opening of the container from one end of the gable panels to an opposite end of the gable panels. The container may be opened in order for a fork or spoon to be used in order to remove contents therefrom.
摘要翻译： 提供了用于存储物品的山形顶部容器。 山形顶部容器具有由至少一个底部形成板制成的底部。 一侧由从底部延伸的至少一个侧面成形板形成。 一对角撑板和一对山墙板从侧面延伸。 山墙面板相对于角撑板布置以形成山墙顶部。 每个山墙板具有鳍，其限定穿孔，其允许去除鳍的至少一部分，以便将容器从山墙板的一端打开到山墙板的相对端。 为了从其中除去内容物，可以打开容器以便使用叉子或勺子。
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公开(公告)号：US11214610B2
公开(公告)日：2022-01-04
申请号：US13466795
申请日：2012-05-08
申请人： Patricia Dianne McNeill , Leon F. Garcia-Martinez , Nicole Janson , Gary Lesnicki , Pei Qi , John A. Latham
发明人： Patricia Dianne McNeill , Leon F. Garcia-Martinez , Nicole Janson , Gary Lesnicki , Pei Qi , John A. Latham
摘要： Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.
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公开(公告)号：US09855332B2
公开(公告)日：2018-01-02
申请号：US13476104
申请日：2012-05-21
申请人： Andrew F. Russo , Eric A. Kaiser , Ana Recober , Adisa Kuburas , Ann C. Raddant , Brian Robert Kovacevich , John A. Latham , Jeffrey T. L. Smith , Leon F. Garcia-Martinez
发明人： Andrew F. Russo , Eric A. Kaiser , Ana Recober , Adisa Kuburas , Ann C. Raddant , Brian Robert Kovacevich , John A. Latham , Jeffrey T. L. Smith , Leon F. Garcia-Martinez
CPC分类号： A61K45/06 , A61K2039/505 , C07K16/26 , C07K2317/24 , C07K2317/76
摘要： The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated CGRP levels, e.g., in the GI tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. More specifically, this invention relates to treatments using the anti-CGRP antibodies and fragments described herein, and binding fragments thereof.
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公开(公告)号：US09745373B2
公开(公告)日：2017-08-29
申请号：US13476465
申请日：2012-05-21
申请人： Brian Robert Kovacevich , Leon F. Garcia-Martinez , Katie Olson , Benjamin H. Dutzar , Jens J. Billgren , John A. Latham , Danielle M. Mitchell , Patricia Dianne Mcneill , Nicole M. Janson , Maria-Cristina Loomis
发明人： Brian Robert Kovacevich , Leon F. Garcia-Martinez , Katie Olson , Benjamin H. Dutzar , Jens J. Billgren , John A. Latham , Danielle M. Mitchell , Patricia Dianne Mcneill , Nicole M. Janson , Maria-Cristina Loomis
CPC分类号： C07K16/18 , A61K31/485 , A61K39/3955 , A61K49/00 , A61K2039/505 , C07K16/26 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.
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