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1.发明授权公开(公告)号：US08703934B2
公开(公告)日：2014-04-22
申请号：US12516939
申请日：2007-11-17
申请人： Peter Nell , Nicole Diedrichs , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süβmeier , Joerg Keldenich
发明人： Peter Nell , Nicole Diedrichs , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süβmeier , Joerg Keldenich
IPC分类号： C07D345/00 , C07D517/00
CPC分类号： C07D417/12 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The present application relates to novel substituted 4-amino-3,5-dicyano-2-thiopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-氨基-3,5-二氰基-2-硫代吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗的药物的用途 和/或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。
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公开(公告)号：US20110136871A1
公开(公告)日：2011-06-09
申请号：US12995028
申请日：2009-05-22
申请人： Walter Hübsch , Daniel Meibom , Alexandros Vakalopoulos , Barbara albrecht-Küpper , Peter Nell , Katja Zimmermann , Frank Süssmeier , Joerg Keldenich
发明人： Walter Hübsch , Daniel Meibom , Alexandros Vakalopoulos , Barbara albrecht-Küpper , Peter Nell , Katja Zimmermann , Frank Süssmeier , Joerg Keldenich
IPC分类号： A61K31/4439 , C07D417/12 , C07D417/14 , C07D413/12 , C07D213/85 , A61K31/4418 , C07D401/12 , A61K31/444 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/10 , A61P9/00
CPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/70 , C07D213/85 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的2-烷氧基取代的二氰基吡啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于 治疗和/或预防心血管疾病。
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3.发明申请公开(公告)号：US20100261771A1
公开(公告)日：2010-10-14
申请号：US12727044
申请日：2010-03-18
申请人： Ulf Brüggemeier , Chantal Fürstner , Volker Geiss , Joerg Keldenich , Armin Kern , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
发明人： Ulf Brüggemeier , Chantal Fürstner , Volker Geiss , Joerg Keldenich , Armin Kern , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
IPC分类号： A61K31/422 , C07D249/12 , A61K31/4196 , C07D413/12 , A61P1/16 , A61P7/10 , A61P9/00
CPC分类号： C07D233/70 , A61K9/0095 , A61K9/2054 , A61K31/4166 , A61K31/4196 , A61K31/422 , A61K45/06 , C07D249/12 , C07D409/04 , C07D413/12 , A61K2300/00
摘要： The present application relates to new, substituted 2-acetamido-5-aryl-1,2,4-triazolones, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的2-乙酰氨基-5-芳基-1,2,4-三唑酮，用于制备它们的方法，单独使用或组合用于治疗和/或预防疾病，以及它们 用于生产用于治疗和/或预防疾病的药物，更具体地用于治疗和/或预防心血管疾病。
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4.发明申请NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS 失效新的替代苄嘧啶衍生物及其作为腺苷受体配体使用公开(公告)号：US20100093728A1
公开(公告)日：2010-04-15
申请号：US12440423
申请日：2007-08-30
IPC分类号： A61K31/5377 , A61K31/495 , A61K31/506 , A61K31/4436 , C07D413/14 , C07D401/14 , C07D417/14 , A61P3/10 , A61P9/04
CPC分类号： C07D417/14 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/85 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本发明涉及新的取代的2,4'-和3,4'-联吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备治疗用药物和 /或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。
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5.发明申请TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING REGORAGENIB 审中-公开含有REGORAGENIB的局部OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION公开(公告)号：US20140296301A1
公开(公告)日：2014-10-02
申请号：US14128356
申请日：2012-06-26
申请人： Michael Bottger , Georges Von Degenfeld , Julia Freundlieb , Claudia Hirth-Dietrich , Joerg Keldenich , Jurgen Klar , Uwe Muenster , Andreas Ohm , Annett Richter , Bernd Riedl
发明人： Michael Bottger , Georges Von Degenfeld , Julia Freundlieb , Claudia Hirth-Dietrich , Joerg Keldenich , Jurgen Klar , Uwe Muenster , Andreas Ohm , Annett Richter , Bernd Riedl
CPC分类号： A61K31/44 , A61K9/0048 , A61K9/10 , A61K31/4412 , A61K47/02 , A61K47/06 , A61K47/14
摘要： The present invention relates to topical ophthalmological pharmaceutical compositions containing regorafenib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders.
摘要翻译： 本发明涉及含有罗非非尼，其水合物，溶剂化物或其药学上可接受的盐或其多晶型物的局部眼科药物组合物及其制备方法及其用于治疗眼科疾病的用途。
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公开(公告)号：US08741834B2
公开(公告)日：2014-06-03
申请号：US13132991
申请日：2009-12-03
申请人： Hans-Georg Lerchen , Daniel Meibom , Alexandros Vakalopoulos , Barbara Albrecht-Küpper , Joerg Keldenich , Katja Zimmermann , Peter Nell , Ursula Krenz
发明人： Hans-Georg Lerchen , Daniel Meibom , Alexandros Vakalopoulos , Barbara Albrecht-Küpper , Joerg Keldenich , Katja Zimmermann , Peter Nell , Ursula Krenz
IPC分类号： A61K38/00 , A61K47/00 , C07D413/00
CPC分类号： C07D413/12 , A61K31/4439 , C07K5/0202 , C07K5/0205 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06086 , C07K5/06104 , C07K5/06113 , C07K5/06147 , C07K5/06165
摘要： The present application relates to dipeptide-like prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
摘要翻译： 本申请涉及2-氨基-6 - （{[2-（4-氯苯基）-1,3-恶唑-4-基]甲基}硫烷基）-4-（4 - {[ 2,3-二羟基丙基]氧基}苯基）吡啶-3,5-二腈，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防的药物的用途 的疾病，特别是心血管疾病。
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7.发明授权Substituted bipyridine derivatives and their use as adenosine receptor ligands 失效取代的联吡啶衍生物及其作为腺苷受体配体的用途公开(公告)号：US08653109B2
公开(公告)日：2014-02-18
申请号：US12440423
申请日：2007-08-30
IPC分类号： A61K31/444 , C07D211/60
CPC分类号： C07D417/14 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/85 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本发明涉及新的取代的2,4'-和3,4'-联吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备治疗用药物和 /或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。
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公开(公告)号：US20130231313A1
公开(公告)日：2013-09-05
申请号：US13819885
申请日：2011-09-14
申请人： Chantal Fürstner , Joerg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
发明人： Chantal Fürstner , Joerg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
IPC分类号： A61K31/4196 , C07D409/04 , A61K45/06 , C07D249/12
CPC分类号： A61K31/4196 , A61K45/06 , C07D249/12 , C07D409/04
摘要： The present application relates to novel substituted phenylacetamides and phenylpropanamides, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的苯乙酰胺和苯丙酰胺，用于制备它们的方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产用于治疗和/或预防的药物的用途 的疾病，更特别地用于治疗和/或预防心血管疾病。
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9.发明申请TRIAZOLE DERIVATIVES AS VASOPRESSIN-RECEPTOR INHIBITORS FOR TREATING CARDIAC INSUFFICIENCY 审中-公开三唑衍生物作为治疗心脏不足的血管收缩素抑制剂公开(公告)号：US20120053218A1
公开(公告)日：2012-03-01
申请号：US13255515
申请日：2010-03-09
申请人： Ulf Brüggemeier , Chantal Fürstner , Volker Geiß , Joerg Keldenich , Armin Kern , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
发明人： Ulf Brüggemeier , Chantal Fürstner , Volker Geiß , Joerg Keldenich , Armin Kern , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
IPC分类号： A61K31/4196 , A61P7/10 , A61P1/00 , A61P7/00 , A61P1/16 , C07D249/12 , A61P9/04
CPC分类号： C07D249/12
摘要： The present application relates to novel substituted phenylalanine derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的苯丙氨酸衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途，以及其用于生产药物用于治疗和/或预防 疾病，更特别地用于治疗和/或预防心血管疾病。
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10.发明申请Aminoacyl Prodrug Derivatives and Medicaments for the Treatment of Thromboembolitic Disorders 有权氨基酰基前体药物和药物用于治疗血栓栓塞性疾病公开(公告)号：US20110034453A1
公开(公告)日：2011-02-10
申请号：US12224007
申请日：2007-02-06
申请人： Hans-Georg Lerchen , Ursula Krenz , Karl-Heinz Schlemmer , Elisabeth Perzborn , Joerg Keldenich
发明人： Hans-Georg Lerchen , Ursula Krenz , Karl-Heinz Schlemmer , Elisabeth Perzborn , Joerg Keldenich
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷-5-基的前药衍生物 ）甲基）噻吩-2-甲酰胺，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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