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公开(公告)号:US20100105671A1
公开(公告)日:2010-04-29
申请号:US12462795
申请日:2009-08-07
申请人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号: A61K31/535 , C07D261/20 , C07D265/30 , C07D207/04 , A61K31/42 , A61K31/40 , A61P31/04
CPC分类号: C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译: 本发明涉及由结构式(A)表示的化合物或其药学上可接受的盐。 结构式(A)的变量在本文中定义。 还描述了包含结构式(A)化合物及其治疗用途的药物组合物。
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公开(公告)号:US08796245B2
公开(公告)日:2014-08-05
申请号:US13718909
申请日:2012-12-18
申请人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号: A61K31/65 , C07C237/26 , C07D205/04 , C07D231/14 , C07D207/12 , C07D213/82 , C07D295/088 , C07D249/04 , C07D261/20 , C07D311/08 , C07D213/74 , C07D209/94 , C07D207/09 , C07D413/12 , C07D295/26 , C07D207/10 , C07D211/60 , C07D231/56 , C07D207/34 , C07D211/76 , C07D207/16 , C07D207/14 , C07D295/15 , A61K45/06 , C07D333/34 , C07D233/61 , C07D333/38 , C07D277/56 , C07D213/81 , C07D239/42 , C07D207/08 , C07D231/12 , C07D261/18 , C07D257/04
CPC分类号: C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译: 本发明涉及由结构式(A)表示的化合物或其药学上可接受的盐。 结构式(A)的变量在本文中定义。 还描述了包含结构式(A)的化合物及其治疗用途的药物组合物。
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公开(公告)号:US20120302527A1
公开(公告)日:2012-11-29
申请号:US13570837
申请日:2012-08-09
申请人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
CPC分类号: C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译: 本发明涉及由结构式(A)表示的化合物或其可药用盐。 结构式(A)的变量在本文中定义。 还描述了包含结构式(A)的化合物及其治疗用途的药物组合物。
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公开(公告)号:US20120208788A1
公开(公告)日:2012-08-16
申请号:US13391407
申请日:2010-08-27
申请人: Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
发明人: Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
IPC分类号: A61K31/65 , A61P31/04 , C07C237/26
CPC分类号: C07C311/08 , C07C237/26 , C07C307/10 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2103/40 , C07C2103/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/40 , C07C2603/44 , C07C2603/46 , C07D205/04 , C07D207/12 , C07D207/16 , C07D209/44 , C07D209/52 , C07D211/54 , C07D211/60 , C07D213/70 , C07D213/74 , C07D213/82 , C07D223/06 , C07D231/18 , C07D233/60 , C07D233/84 , C07D295/15 , C07D307/64
摘要: The present invention is directed to a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
摘要翻译: 本发明涉及由结构式(1)表示的化合物或其药学上可接受的盐。 结构式(I)的变量在本文中定义。 还描述了包含结构式(I)的化合物及其治疗用途的药物组合物。
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公开(公告)号:US08501716B2
公开(公告)日:2013-08-06
申请号:US13570837
申请日:2012-08-09
申请人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号: A61K31/65 , C07C237/26
CPC分类号: C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译: 本发明涉及由结构式(A)表示的化合物或其药学上可接受的盐。 结构式(A)的变量在本文中定义。 还描述了包含结构式(A)的化合物及其治疗用途的药物组合物。
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公开(公告)号:US20130109657A1
公开(公告)日:2013-05-02
申请号:US13718909
申请日:2012-12-18
申请人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号: A61K31/65 , C07D207/09 , A61K45/06
CPC分类号: C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
摘要翻译: 本发明涉及由结构式(A)表示的化合物或其药学上可接受的盐。 结构式(A)的变量在本文中定义。 还描述了包含结构式(A)化合物及其治疗用途的药物组合物。
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公开(公告)号:US09624166B2
公开(公告)日:2017-04-18
申请号:US13391407
申请日:2010-08-27
申请人: Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
发明人: Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
IPC分类号: A61K31/65 , A61P31/04 , C07C237/26 , C07C311/08 , C07C307/10 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/44 , C07D205/04 , C07D207/12 , C07D207/16 , C07D209/44 , C07D209/52 , C07D211/54 , C07D211/60 , C07D213/70 , C07D213/74 , C07D213/82 , C07D223/06 , C07D231/18 , C07D233/60 , C07D233/84 , C07D295/15 , C07D307/64
CPC分类号: C07C311/08 , C07C237/26 , C07C307/10 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2103/40 , C07C2103/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/40 , C07C2603/44 , C07C2603/46 , C07D205/04 , C07D207/12 , C07D207/16 , C07D209/44 , C07D209/52 , C07D211/54 , C07D211/60 , C07D213/70 , C07D213/74 , C07D213/82 , C07D223/06 , C07D231/18 , C07D233/60 , C07D233/84 , C07D295/15 , C07D307/64
摘要: The present invention is directed to a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
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公开(公告)号:US08906887B2
公开(公告)日:2014-12-09
申请号:US12462795
申请日:2009-08-07
申请人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
发明人: Jingye Zhou , Xiao-Yi Xiao , Louis Plamondon , Diana Katharine Hunt , Roger B. Clark , Robert B. Zahler
IPC分类号: A61K31/65 , C07C237/26 , C07D233/61 , C07D207/34 , C07D295/088 , C07D211/60 , C07D257/04 , C07D295/15 , C07D209/94 , C07D231/14 , A61K45/06 , C07D207/14 , C07D333/34 , C07C311/08 , C07D231/56 , C07C311/21 , C07D207/10 , C07D413/12 , C07D213/81 , C07D249/04 , C07D261/20 , C07D207/09 , C07D239/42 , C07D333/38 , C07D277/56 , C07D207/08 , C07D231/12 , C07D207/12 , C07D213/82 , C07D205/04 , C07D295/26 , C07D207/16 , C07D261/18 , C07D211/76 , C07D213/74
CPC分类号: C07C233/57 , A61K31/65 , A61K45/06 , C07C311/08 , C07C311/21 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/34 , C07D209/94 , C07D211/60 , C07D211/76 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/61 , C07D239/42 , C07D249/04 , C07D257/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D295/088 , C07D295/12 , C07D295/15 , C07D295/26 , C07D311/08 , C07D333/34 , C07D333/38 , C07D413/12 , Y02A50/402 , Y02A50/406 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
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