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公开(公告)号：US20130203818A1
公开(公告)日：2013-08-08
申请号：US13643537
申请日：2011-04-27
申请人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： C07D231/12 , C07D417/12 , C07D405/12 , C07D413/12 , C07D409/04 , C07D231/14 , C07D417/14 , C07D231/16 , C07D413/04 , C07D413/14 , C07D405/04 , C07D401/12 , C07D409/14
CPC分类号： C07D417/12 , C07C233/75 , C07C233/80 , C07C233/92 , C07C255/60 , C07C2601/02 , C07D213/81 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/56 , C07D263/57 , C07D277/34 , C07D277/56 , C07D317/62 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US20100261725A1
公开(公告)日：2010-10-14
申请号：US12548189
申请日：2009-08-26
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/498 , C07D263/54 , A61K31/423 , C07D471/04 , A61K31/437 , C07D491/048 , A61K31/4355 , C07D495/04 , A61K31/381 , C07D333/36 , C07D217/00 , A61K31/47 , C07D277/62 , A61K31/428 , C07D241/36 , C07D285/06 , A61K31/433 , A61P37/06 , A61P29/00
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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公开(公告)号：US20080027070A1
公开(公告)日：2008-01-31
申请号：US11772572
申请日：2007-07-02
申请人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Binqi Zeng , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Binqi Zeng , Elena Dneprovskaia
IPC分类号： A61K31/495 , A61K31/505 , A61P19/02 , A61P27/02 , A61P29/00 , A61P3/10 , A61P35/00 , A61P9/00 , C07D239/02
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12
摘要： Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases.
摘要翻译： 提供具有一般结构（A）的化合物。 本发明的化合物能够抑制激酶，例如Src激酶家族的成员，Vegfr和各种其它特异性受体和非受体激酶。
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公开(公告)号：US20070191405A1
公开(公告)日：2007-08-16
申请号：US11588638
申请日：2006-10-26
申请人： Glenn Noronha , Chi Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved Pathak , Daniel Lohse , John Hood , Richard Soll
发明人： Glenn Noronha , Chi Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved Pathak , Daniel Lohse , John Hood , Richard Soll
IPC分类号： A61K31/506 , C07D403/02 , C07D407/02
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
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公开(公告)号：US20130345193A1
公开(公告)日：2013-12-26
申请号：US13975238
申请日：2013-08-23
申请人： Jeffrey P. WHITTEN , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Jeffrey P. WHITTEN , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： C07D405/04 , C07D413/14 , C07D471/04 , C07D413/04 , C07D213/75 , C07D417/04
CPC分类号： C07D213/74 , C07D213/75 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D493/10 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US08604042B2
公开(公告)日：2013-12-10
申请号：US12862517
申请日：2010-08-24
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/42 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
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公开(公告)号：US08519121B2
公开(公告)日：2013-08-27
申请号：US13000194
申请日：2008-06-23
申请人： Jinkui Xie , Anqiang Zhang , Jianguo Cao
发明人： Jinkui Xie , Anqiang Zhang , Jianguo Cao
IPC分类号： C08B37/02
CPC分类号： C08B37/0021 , C08B37/0003
摘要： Dextran for preparing medicine for anti-lung cancer, has repeated structure unit and molecular weight of 1.5-2.5 million Daltons. The dextran is extracted from land slug.
摘要翻译： 用于制备抗肺癌药物的葡聚糖，重复结构单元和分子量为1.5-2.5万道尔顿。 葡聚糖从土地中提取。
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公开(公告)号：US08394848B2
公开(公告)日：2013-03-12
申请号：US13006701
申请日：2011-01-14
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/38
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US08383670B2
公开(公告)日：2013-02-26
申请号：US13050724
申请日：2011-03-17
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/38
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds of Formula (I): wherein A, J, Z, X, R1, and R4 are defined herein, and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述的是式（I）的化合物：其中A，J，Z，X，R 1和R 4在本文中定义，以及含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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公开(公告)号：US20120316182A1
公开(公告)日：2012-12-13
申请号：US13492574
申请日：2012-06-08
申请人： Jeffrey P. WHITTEN , Jonathan Grey , Jianguo Cao , Zhijun Wang , Evan Rogers
发明人： Jeffrey P. WHITTEN , Jonathan Grey , Jianguo Cao , Zhijun Wang , Evan Rogers
IPC分类号： A61K31/443 , C07D213/74 , A61K31/4418 , A61K31/497 , C07D417/04 , A61K31/4439 , A61K31/506 , A61P29/00 , A61P13/12 , A61P27/02 , A61P1/16 , A61P11/00 , A61P1/00 , A61P17/00 , A61P19/02 , A61P21/00 , A61P37/08 , A61P15/02 , A61P19/10 , A61P37/06 , A61P19/04 , A61P3/10 , A61P5/16 , A61P21/04 , A61P7/06 , A61P31/14 , A61P11/06 , A61P17/06 , A61P25/00 , A61P37/00 , C07D405/10
CPC分类号： C07D405/04 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/497 , A61K31/506 , C07D213/74 , C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/10 , C07D417/04 , C07D491/04 , C07D491/056
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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