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公开(公告)号：US20120128739A1
公开(公告)日：2012-05-24
申请号：US13377430
申请日：2010-06-25
CPC分类号： C12N5/0602 , A61L27/34 , A61L27/56 , C12N2533/20 , C12N2533/50
摘要： A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an open network and provides mechanical support of a second biocompatible material. The second biocompatible material has interconnected cavities that allow nutrients, metabolites and soluble factors to diffuse throughout the scaffold. The scaffold design can be understood as a hierarchically organised structure. At the micron to submicron length scale a top/down manufacturing approach is used to make a structure that will constitute the frame into which a bottom/up processing approach is applied to form an open porous scaffold with specific nano sized features. The advantage of this hierarchically organised design is that benefits can be drawn independently from both the micron and the nano sized structures, promoting specific cell activities and providing sufficient mechanical compliance.
摘要翻译： 制备能够支持细胞活性如生长和分化的三维生物相容性支架的方法包括提供形成开放网络并提供第二生物相容性材料的机械支撑的支撑网格。 第二种生物相容性材料具有互连的空腔，其允许营养物，代谢物和可溶性因子在整个支架中扩散。 脚手架设计可以理解为层次结构。 在微米到亚微米长度尺度上，使用顶部/底部制造方法来制造构成框架的结构，其中应用底部/上部加工方法以形成具有特定纳米尺寸特征的开放多孔支架。 这种分级组织设计的优点在于可以独立于微米和纳米尺寸的结构，从而促进特定的细胞活动并提供足够的机械依从性。
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2.发明申请METHOD FOR CALCULATING PRESSURES IN A FLUID STREAM THROUGH A TUBE SECTION, ESPECIALLY A BLOOD VESSEL WITH ATHEROSCLEROTIC PLAQUE 审中-公开通过管段计算流体流中的压力的方法，特别是具有自由流动性的血管公开(公告)号：US20100298719A1
公开(公告)日：2010-11-25
申请号：US12734429
申请日：2008-10-31
IPC分类号： A61B5/021
CPC分类号： A61B5/02028 , A61B5/055 , G06T7/0012 , G06T2207/10072 , G06T2207/20044 , G06T2207/30104 , G16H50/50
摘要： A method for calculating pressures in a fluid streaming through a tube section from an upstream end to a downstream end of the tube section, the method comprising scanning the tube section with a scanner and providing a plurality of 2D scanning images along the tube section with an inlet and at least two arms, by a computer program on the basis of the 2D images automatically N calculating a 3D image of the tube section by using interpolating between the 2D images, by a computer program performing a 2D sectional image cut through the 3D image, the image cut following the fluid stream, calculating in the sectional image cut a fluid pressure distribution along multiple locations inside the tube on the basis of given boundary conditions, the boundary conditions including fluid velocity or fluid pressure at the upstream end.
摘要翻译： 一种用于计算从管部分从管部分的上游端到下游端流动的流体中的压力的方法，所述方法包括用扫描仪扫描管部分，并且沿着管部分提供多个2D扫描图像， 入口和至少两个臂，通过基于2D图像的计算机程序自动地通过在2D图像之间进行内插来计算管部分的3D图像，通过执行通过3D图像切割的2D截面图像的计算机程序 根据流体流切割的图像，根据给定的边界条件，边界条件包括流体速度或上游端的流体压力，在截面图像中计算切割管内多个位置的流体压力分布。
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公开(公告)号：US20130211543A1
公开(公告)日：2013-08-15
申请号：US13880204
申请日：2011-10-07
申请人： Muwan Chen , Dang Quang Sven Le , San Hein , Jørgen Kjems , Cody Eric Bünger , Jens Vinge Nygaard
发明人： Muwan Chen , Dang Quang Sven Le , San Hein , Jørgen Kjems , Cody Eric Bünger , Jens Vinge Nygaard
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , A61L27/446 , A61L27/46 , A61L27/54 , A61L27/56 , A61L2300/416 , A61L2300/602 , A61L2430/02 , A61L2430/06 , A61L2430/38
摘要： A three-dimensional hybrid scaffold capable of supporting cell activities such as growth and differentiation, and capable of controlled release of active pharmaceutical ingredients, characterized in that the scaffold comprises a first and a second biocompatible material, said first material shaped as a framework forming one or more open networks of voids, said second material comprising an ion exchange material, said ion exchange material being loaded with one or more active pharmaceutical ingredients.
摘要翻译： 能够支持诸如生长和分化的细胞活性并且能够控制释放活性药物成分的三维杂交支架，其特征在于所述支架包括第一和第二生物相容性材料，所述第一材料形成为骨架形成一个 或更多开放的空隙网络，所述第二材料包括离子交换材料，所述离子交换材料装载有一种或多种活性药物成分。
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公开(公告)号：US08815276B2
公开(公告)日：2014-08-26
申请号：US13377430
申请日：2010-06-25
IPC分类号： A61F2/00
CPC分类号： C12N5/0602 , A61L27/34 , A61L27/56 , C12N2533/20 , C12N2533/50
摘要： A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an open network and provides mechanical support of a second biocompatible material. The second biocompatible material has interconnected cavities that allow nutrients, metabolites and soluble factors to diffuse throughout the scaffold. The scaffold design can be understood as a hierarchically organised structure. At the micron to submicron length scale a top/down manufacturing approach is used to make a structure that will constitute the frame into which a bottom/up processing approach is applied to form an open porous scaffold with specific nano sized features. The advantage of this hierarchically organised design is that benefits can be drawn independently from both the micron and the nano sized structures, promoting specific cell activities and providing sufficient mechanical compliance.
摘要翻译： 制备能够支持细胞活性如生长和分化的三维生物相容性支架的方法包括提供形成开放网络并提供第二生物相容性材料的机械支撑的支撑网格。 第二种生物相容性材料具有互连的空腔，其允许营养物，代谢物和可溶性因子在整个支架中扩散。 脚手架设计可以理解为层次结构。 在微米到亚微米长度尺度上，使用顶部/底部制造方法来制造构成框架的结构，其中应用底部/上部加工方法以形成具有特定纳米尺寸特征的开放多孔支架。 这种分级组织设计的优点在于可以独立于微米和纳米尺寸的结构，从而促进特定的细胞活动并提供足够的机械依从性。
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公开(公告)号：US08741631B2
公开(公告)日：2014-06-03
申请号：US13375785
申请日：2010-06-03
摘要： A device for biological purposes such as cell culturing, enzymatic reactions or filtering of fluid has a body with first and second surfaces. The body is delimited by a rim and an aperture in the center of the body. The aperture is covered at the first and second surface by first and second plates. The first and/or second plate has an inlet orifice allowing liquid medium into the aperture. Rotating means are arranged in the aperture between the first and second plate. At least one recessed portion is a cavity in the rim of the body having a first outlet orifice allowing the liquid medium to flow out of the body. At least one outlet channel connects the circular aperture with the recessed portion. Liquid is pumped into the aperture of the device and pumped through at least one outlet channel.
摘要翻译： 用于生物学目的的装置如细胞培养，酶反应或流体过滤具有具有第一和第二表面的主体。 身体由身体中心的边缘和孔限定。 孔由第一和第二板覆盖在第一和第二表面。 第一和/或第二板具有允许液体介质进入孔的入口孔。 旋转装置布置在第一和第二板之间的孔中。 至少一个凹部是本体边缘中的空腔，其具有允许液体介质从身体流出的第一出口孔。 至少一个出口通道将圆形孔与凹部连接。 液体被泵送到设备的孔中并泵送通过至少一个出口通道。
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公开(公告)号：US20120171718A1
公开(公告)日：2012-07-05
申请号：US13375785
申请日：2010-06-03
摘要： A device for biological purposes such as cell culturing, enzymatic reactions or filtering of fluid has a body with first and second surfaces. The body is delimited by a rim and an aperture in the center of the body. The aperture is covered at the first and second surface by first and second plates. The first and/or second plate has an inlet orifice allowing liquid medium into the aperture. Rotating means are arranged in the aperture between the first and second plate. At least one recessed portion is a cavity in the rim of the body having a first outlet orifice allowing the liquid medium to flow out of the body. At least one outlet channel connects the circular aperture with the recessed portion. Liquid is pumped into the aperture of the device and pumped through at least one outlet channel.
摘要翻译： 用于生物学目的的装置如细胞培养，酶反应或流体过滤具有具有第一和第二表面的主体。 身体由身体中心的边缘和孔限定。 孔由第一和第二板覆盖在第一和第二表面。 第一和/或第二板具有允许液体介质进入孔的入口孔。 旋转装置布置在第一和第二板之间的孔中。 至少一个凹部是本体边缘中的空腔，其具有允许液体介质从身体流出的第一出口孔。 至少一个出口通道将圆形孔与凹部连接。 液体被泵送到设备的孔中并泵送通过至少一个出口通道。
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