公开(公告)号：US20070195269A1

公开(公告)日：2007-08-23

申请号：US11656075

申请日：2007-01-19

Applicant: Jay Wei ,  Ben Jang ,  David Huang ,  Yonghua Zhao

Inventor： Jay Wei ,  Ben Jang ,  David Huang ,  Yonghua Zhao

IPC: A61B3/10

CPC classification number: A61B3/102 ,  A61B3/113 ,  G06T7/11 ,  G06T2207/10101 ,  G06T2207/20128 ,  G06T2207/30041

Abstract: A method of performing an OCT image scan is presented. Other images are taken and a template is formed to correct the OCT images, for example, for eye motion, blood vessel placement, and center offset. In some embodiments, video images are taken simultaneously with the OCT images and utilized to correct the OCT images. In some embodiments, a template OCT image is formed prior to acquisition of the OCT images and the template OCT image is utilized as a template from which to correct all of the OCT images.

Abstract translation: 提出了执行OCT图像扫描的方法。 拍摄其他图像，并且形成模板以校正OCT图像，例如用于眼动，血管放置和中心偏移。 在一些实施例中，与OCT图像同时拍摄视频图像并用于校正OCT图像。 在一些实施例中，在获取OCT图像之前形成模板OCT图像，并且将模板OCT图像用作校正所有OCT图像的模板。

公开(公告)号：US20050174578A1

公开(公告)日：2005-08-11

申请号：US11055900

申请日：2005-02-10

Applicant: Jay Wei

Inventor： Jay Wei

IPC: A61B3/10 ,  G01B9/02

CPC classification number: A61B3/102

Abstract: In accordance with the present invention, embodiments of interferometers are presented that improves both the polarization dependency problem and helps prevents light from being reflected back into the light source, among other things. Interferometer embodiments can include an isolator coupled to a light source and polarization dependent optics coupled with the isolator to provide light to a reference arm and a sample arm, wherein reflected light provided to optical detectors is such that a polarization independent optical signal can be formed in an optical signal processor coupled to the optical detectors, and the isolator blocks reflected light from the reference arm and the sample arm from entering the light source. In some embodiments, a balanced detection system can be utilized to reduce noise.

Abstract translation: 根据本发明，提出了改善偏振依赖性问题并且有助于防止光反射回到光源中的干涉仪的实施例。 干涉仪实施例可以包括耦合到光源的隔离器和与隔离器耦合的偏振相关光学器件，以向参考臂和样本臂提供光，其中提供给光学检测器的反射光使得可以形成与偏振无关的光信号 耦合到光学检测器的光信号处理器，并且隔离器阻挡来自参考臂和样本臂的反射光进入光源。 在一些实施例中，可以利用平衡检测系统来降低噪声。

公开(公告)号：US6004314A

公开(公告)日：1999-12-21

申请号：US832598

申请日：1997-03-31

Applicant: Jay Wei ,  Thomas Hellmuth

Inventor： Jay Wei ,  Thomas Hellmuth

IPC: A61F9/007 ,  A61B3/107 ,  A61B18/20 ,  A61F9/008 ,  A61F9/01 ,  G01B9/02 ,  G02B21/00 ,  A61N5/02

CPC classification number: G02B21/0012 ,  A61B3/102 ,  A61B3/13 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00821 ,  G01B9/02002 ,  G01B9/0203 ,  G01B9/02089 ,  G01B9/02091 ,  A61B18/20 ,  A61B2018/00636 ,  A61F2009/00851 ,  A61F2009/00853 ,  A61F2009/00863 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/00887

Abstract: Ophthalmologic surgical microscope which is combined internally with an optical coherence tomography ("OCT") apparatus wherein auto-focusing is provided by driving a motorized internal focusing lens of the ophthalmologic surgical microscope with a signal output from the OCT apparatus. An embodiment of the inventive ophthalmologic surgical microscope includes: (a) an optical coherence tomography ("OCT") apparatus; (b) a beamcombiner for internally coupling output from the OCT apparatus into the ophthalmologic surgical microscope; and (c) a motor for moving an internal focusing lens of the ophthalmologic surgical microscope in response to a signal from the OCT apparatus, whereby the ophthalmologic surgical microscope is auto-focused.

Abstract translation: 在内部与光学相干断层摄影（“OCT”）装置组合的眼科手术显微镜，其中通过从OCT装置输出的信号驱动眼科手术显微镜的机动化内部聚焦透镜来提供自动聚焦。 本发明的眼科手术显微镜的一个实施例包括：（a）光学相干断层摄影（“OCT”）装置; （b）用于将OCT设备的输出内部耦合到眼科手术显微镜中的束联合器; 和（c）用于响应于来自OCT装置的信号移动眼科手术显微镜的内部聚焦透镜的电动机，由此眼科手术显微镜被自动聚焦。

公开(公告)号：US5506634A

公开(公告)日：1996-04-09

申请号：US270750

申请日：1994-07-05

Applicant: Jay Wei ,  Thomas Hellmuth

Inventor： Jay Wei ,  Thomas Hellmuth

IPC: A61B3/12 ,  A61B3/13 ,  A61B3/14 ,  A61B3/15 ,  A61B3/10

CPC classification number: A61B3/156 ,  A61B3/12

Abstract: Apparatus for illuminating the fundus of an eye with a scanned sample beam of radiation. An embodiment of the present invention is an optical system which includes three, separated radiation path systems--a tilted illumination path system, a decentered observation path system, and an optical path system--which are combined by a beamsplitter into an ocular lens. In accordance with the present invention, an illuminating path provided by the illumination path system and an optical beam path provided by the optical beam path system are obliquely oriented with respect to the optical axis of the ocular lens.

Abstract translation: 用扫描的样本辐射束照射眼睛的眼底的装置。 本发明的实施例是一种光学系统，其包括三个分离的辐射路径系统 - 倾斜照明路径系统，偏心观察路径系统和光路系统，其由分束器组合成眼睛透镜。 根据本发明，由照明路径系统提供的照明路径和由光束路径系统提供的光束路径相对于眼镜片的光轴倾斜定向。

公开(公告)号：US5491524A

公开(公告)日：1996-02-13

申请号：US318141

申请日：1994-10-05

Applicant: Thomas Hellmuth ,  Jay Wei

Inventor： Thomas Hellmuth ,  Jay Wei

IPC: A61B3/10 ,  A61B3/107 ,  G01B9/02

CPC classification number: A61B3/102 ,  A61B3/107 ,  G01B9/0203 ,  G01B9/02091 ,  G01B2290/15 ,  G01B2290/35 ,  G01B2290/65

Abstract: Optical coherence tomography ("OCT") corneal mapping apparatus includes an OCT apparatus having a rotating helical mirror for altering a reference beam path in the OCT apparatus; a raster scanner for raster scanning sampling optical output from the OCT apparatus; a curved mirror for transferring the sampling optical output from the raster scanner to an eye and for transferring sampling optical output reflected from the eye back to the OCT apparatus through the raster scanner; and an analyzer, coupled to the raster scanner, the rotating helical mirror, and reference and sampling interaction output from the OCT apparatus. The analyzer causes the raster scanner to scan the sampling optical output to points in a raster; causes the rotating mirror to alter the length of the reference beam path over a predetermined amount at each of the points in the raster; and provides the corneal mapping from the reference and sampling interaction output at the points in the raster.

Abstract translation: 光学相干断层扫描（“OCT”）角膜测绘装置包括具有用于改变OCT装置中的参考光束路径的旋转螺旋镜的OCT设备; 用于光栅扫描的光栅扫描器，从OCT装置采样光输出; 用于将采样光输出从光栅扫描器传送到眼睛并用于通过光栅扫描器将从眼睛反射的采样光输出传送回OCT设备的曲面镜; 以及耦合到光栅扫描器，旋转螺旋镜以及OCT设备的参考和采样交互输出的分析器。 分析仪使光栅扫描仪将采样光输出扫描到光栅中的点; 使得旋转镜在光栅中的每个点处改变参考光束路径的长度超过预定量; 并从栅格中的点处的参考和采样交互输出提供角膜映射。

公开(公告)号：US08770753B2

公开(公告)日：2014-07-08

申请号：US13310626

申请日：2011-12-02

Applicant: Michael Hee ,  Jay Wei ,  David Huang ,  Qienyuan Zhou ,  Yonghua Zhao ,  Ben Jang ,  Tony Ko

Inventor： Michael Hee ,  Jay Wei ,  David Huang ,  Qienyuan Zhou ,  Yonghua Zhao ,  Ben Jang ,  Tony Ko

IPC: A61B3/14 ,  A61B3/10 ,  A61B3/12

CPC classification number: A61B3/102 ,  A61B3/0025 ,  A61B3/107 ,  A61B3/1225 ,  A61B3/14

Abstract: In accordance with some embodiments, a method of eye examination includes acquiring OCT data with a scan pattern centered on an eye cornea that includes n radial scans repeated r times, c circular scans repeated r times, and n* raster scans where the scan pattern is repeated m times, where each scan includes a A-scans, and where n is an integer that is 0 or greater, r is an integer that is 1 or greater, c is an integer that is 0 or greater, n* is an integer that is 0 or greater, m is an integer that is 1 or greater, and a is an integer greater than 1, the values of n, r, c, n*, and m being chosen to provide OCT data for a target measurement, and processing the OCT data to obtain the target measurement.

Abstract translation: 根据一些实施例，眼睛检查的方法包括以包括眼睛角膜为中心的扫描图案来获取OCT数据，该扫描图案包括重复r次的n个径向扫描，c次循环扫描重复r次，以及扫描模式为 重复m次，其中每个扫描包括A扫描，并且其中n是0或更大的整数，r是1或更大的整数，c是0或更大的整数，n *是整数 0或更大，m是1或更大的整数，a是大于1的整数，n，r，c，n *和m的值被选择为提供用于目标测量的OCT数据， 并处理OCT数据以获得目标测量。

公开(公告)号：US20130039557A1

公开(公告)日：2013-02-14

申请号：US13569892

申请日：2012-08-08

Applicant: Jay WEI ,  Ben JANG

Inventor： Jay WEI ,  Ben JANG

IPC: G06K9/40

CPC classification number: G06T7/0016 ,  G06K9/00214 ,  G06K9/6201 ,  G06T2207/10101 ,  G06T2207/20201 ,  G06T2207/30041

Abstract: An optical coherence tomography system is provided. The system includes an OCT imager; a two-dimensional transverse scanner coupled to the OCT imager, the two-dimensional transverse scanner receiving light from the light source and coupling reflected light from a sample into the OCT imager; a computer coupled to receive 3D OCT data from the OCT imager, the computer further processes the 3D OCT data; wherein the processing the 3D OCT data includes: correcting motion artifacts in baseline mode; generating reference data in baseline mode; performing segmentation to identify volumes of interest; extracting feature information, the feature information including reflectivity, texture, or the combination thereof.

Abstract translation: 提供光学相干断层摄影系统。 该系统包括OCT成像仪; 耦合到OCT成像器的二维横向扫描器，二维横向扫描器接收来自光源的光并将来自样品的反射光耦合到OCT成像器中; 耦合以从OCT成像仪接收3D OCT数据的计算机，该计算机进一步处理3D OCT数据; 其中处理所述3D OCT数据包括：在基线模式下校正运动伪像; 在基线模式下生成参考数据; 执行细分以识别感兴趣的体积; 提取特征信息，特征信息包括反射率，纹理或其组合。

公开(公告)号：US20110292341A1

公开(公告)日：2011-12-01

申请号：US13150999

申请日：2011-06-01

Applicant: Seema SOMANI ,  Jay WEI

Inventor： Seema SOMANI ,  Jay WEI

IPC: A61B3/15 ,  A61B3/14

CPC classification number: A61B3/152 ,  A61B3/102

Abstract: An imaging method according to some embodiments of the present invention includes obtaining working distance information from an optical coherence tomography system, the working distance being the working distance to the sample; obtaining information from one or more ocular systems; combining the information from said optical coherence tomography information and said ocular system; and displaying said combined information.

Abstract translation: 根据本发明的一些实施例的成像方法包括从光学相干断层摄影系统获得工作距离信息，工作距离是到样品的工作距离; 从一个或多个眼睛系统获取信息; 组合来自所述光学相干断层摄影信息和所述眼睛系统的信息; 并显示所述组合信息。

公开(公告)号：US07744221B2

公开(公告)日：2010-06-29

申请号：US11656075

申请日：2007-01-19

Applicant: Jay Wei ,  Ben Jang ,  David Huang ,  Yonghua Zhao

Inventor： Jay Wei ,  Ben Jang ,  David Huang ,  Yonghua Zhao

IPC: A61B3/00

CPC classification number: A61B3/102 ,  A61B3/113 ,  G06T7/11 ,  G06T2207/10101 ,  G06T2207/20128 ,  G06T2207/30041

Abstract: A method of performing an OCT image scan is presented. Other images are taken and a template is formed to correct the OCT images, for example, for eye motion, blood vessel placement, and center offset. In some embodiments, video images are taken simultaneously with the OCT images and utilized to correct the OCT images. In some embodiments, a template OCT image is formed prior to acquisition of the OCT images and the template OCT image is utilized as a template from which to correct all of the OCT images.

Abstract translation: 提出了执行OCT图像扫描的方法。 拍摄其他图像，并且形成模板以校正OCT图像，例如用于眼动，血管放置和中心偏移。 在一些实施例中，与OCT图像同时拍摄视频图像并用于校正OCT图像。 在一些实施例中，在获取OCT图像之前形成模板OCT图像，并且将模板OCT图像用作校正所有OCT图像的模板。

公开(公告)号：US07480058B2

公开(公告)日：2009-01-20

申请号：US11656222

申请日：2007-01-19

Applicant: Yonghua Zhao ,  Jay Wei

Inventor： Yonghua Zhao ,  Jay Wei

IPC: G01B9/02

CPC classification number: G01B9/02044 ,  G01B9/02068 ,  G01B9/02087 ,  G01B9/02091 ,  G01J3/02 ,  G01J3/0289 ,  G01J3/45 ,  G01J3/4537

Abstract: A Fourier-domain optical coherence tomography (OCT) imager is presented. An OCT imager according to the present invention can have an auto-alignment process. The auto-alignment process automatically adjusts at least one optical component of a spectrometer of the imager so that the spectrometer is aligned during an imaging session. In addition to the auto-alignment process, OCT spectra are normalized for background spectra and for noise characteristics in order to provide a more accurate and clear OCT image.

Abstract translation: 提出了傅里叶域光学相干断层扫描（OCT）成像仪。 根据本发明的OCT成像器可以具有自动对准过程。 自动对准过程自动调整成像仪的光谱仪的至少一个光学组件，使得光谱仪在成像会话期间对准。 除了自动对准过程之外，为了提供更精确和更清晰的OCT图像，将OCT光谱归一化用于背景光谱和噪声特性。