公开(公告)号：US4536217A

公开(公告)日：1985-08-20

申请号：US537151

申请日：1983-09-28

申请人： Fritz Loth ,  Horst Dautzenberg ,  Jiri Stamberg ,  Jan Peska ,  Dieter Bertram ,  Herbert Lettau

发明人： Fritz Loth ,  Horst Dautzenberg ,  Jiri Stamberg ,  Jan Peska ,  Dieter Bertram ,  Herbert Lettau

IPC分类号： A61L26/00 ,  C08B1/00

CPC分类号： A61L26/0023

摘要： The invention pertains to the absorbing dressing for wounds, which consists of spherical particles of regenerated cellulose of the size 0.05-0.5 mm (preferably 0.05-0.3 mm) and a macroporous structure characterized by the cyclohexane regain of the dry material at least 0.2 ml/g. The dressing is prepared from the regenerated cellulose swollen with water by replacement with organic solvents and the subsequent drying of the product swollen with the said solvent. The porous structure of the dressing warrants that it can absorb excretions of the wound in the amount 1.5 to 5 g water per g of solids; the grainy macrostructure remains preserved during the absorption so that the material applied on the wound in the form of a powder in the layer 2-5 mm thick, in particular 2-3 mm thick, can be without difficulties and almost without pain rinsed away with water.

摘要翻译： 本发明涉及用于伤口的吸收敷料，其由尺寸为0.05-0.5mm（优选0.05-0.3mm）的再生纤维素的球形颗粒组成，其特征在于干燥材料的环己烷回收率为至少0.2ml / G。 敷料由用有机溶剂置换的再生纤维素溶液制备，随后用所述溶剂干燥产物溶胀。 敷料的多孔结构保证其可以吸收每克固体量为1.5至5g水的伤口排泄物; 颗粒状宏观结构在吸收期间保持保留，使得以2-5mm厚，特别是2-3mm厚的层施加在粉末形式的伤口上的材料可以是没有困难的，几乎没有疼痛被冲洗掉 水。

公开(公告)号：US4011204A

公开(公告)日：1977-03-08

申请号：US302897

申请日：1972-11-01

申请人： Milan Benes ,  Jan Peska

发明人： Milan Benes ,  Jan Peska

IPC分类号： C02F1/54 ,  C07D213/20 ,  C07D213/82 ,  C07D215/10 ,  C07D277/22 ,  C07D277/24 ,  C07D277/30 ,  C08F20/34 ,  C08F28/00 ,  C08F3/84 ,  C08F7/12 ,  C08F15/02

CPC分类号： C07D213/20 ,  C02F1/54 ,  C07D213/82 ,  C07D215/10 ,  C07D277/22 ,  C07D277/24 ,  C08F20/34 ,  C08F28/00

摘要： The invention relates to quaternary cationic monomers and polymers and copolymers prepared thereof, based upon salts of methacrylic or acrylic esters of the general formula I ##STR1## where R.sup.1 is H or CH.sub.3 r.sup. 2 is CH.sub. 3 , C.sub. 6 H.sub. 5 or p-CH.sub. 3 C.sub. 6 H.sub. 4n is 1 or 2, andY.sup.+ is --N.sup.+(CH.sub.3).sub.3, --N.sup.+(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 OH, ##STR2## where R.sup.3 is H, CH.sub.3, CONH.sub.2, CHO, COCH.sub.3 andR.sup.4 is H or CH.sub.2 CH.sub.2 OH.The invention further relates to some methods for preparation of monomers, polymers and copolymers of the aforegiven salts. The polymers and copolymers exhibit the properties of polyelectrolytes and ion exchange resins.

公开(公告)号：US4615880A

公开(公告)日：1986-10-07

申请号：US599637

申请日：1984-04-12

申请人： Frith Loth ,  Horst Dautzenberg ,  Jiri Stamberg ,  Jan Peska ,  Dieter Bertram ,  Herbert Lettau

发明人： Frith Loth ,  Horst Dautzenberg ,  Jiri Stamberg ,  Jan Peska ,  Dieter Bertram ,  Herbert Lettau

IPC分类号： A61L26/00 ,  A61K9/16 ,  A61K9/18 ,  A61L15/03

CPC分类号： A61L26/0023

摘要： An absorbing dressing for wounds consists of spherical particles of regenerated cellulose of the size 0.05-0.5 mm and a macroporous structure characterized by the cyclohexane regain of the dry material at least 0.2 ml/g. The dressing is prepared from the regenerated cellulose swollen with water by replacement with organic solvents and the subsequent drying of the product swollen with the said solvent and impregnated with a therapeutically active compound.

摘要翻译： 用于伤口的吸收性敷料由尺寸为0.05-0.5mm的再生纤维素的球形颗粒组成，其特征在于干物质的环己烷重吸收率至少为0.2ml / g。 该敷料由用有机溶剂置换的再生纤维素溶液制备，随后用所述溶剂干燥产物并用治疗活性化合物浸渍。

公开(公告)号：US4599209A

公开(公告)日：1986-07-08

申请号：US627485

申请日：1984-07-05

申请人： Horst Dautzenberg ,  Fritz Loth ,  Bodo Borrmeister ,  Dieter Bertram ,  Herbert Lettau ,  Jiri Stamberg ,  Jan Peska

发明人： Horst Dautzenberg ,  Fritz Loth ,  Bodo Borrmeister ,  Dieter Bertram ,  Herbert Lettau ,  Jiri Stamberg ,  Jan Peska

IPC分类号： A61F13/00 ,  A61L15/22 ,  C08J9/00 ,  C08L1/24 ,  B29B9/00

CPC分类号： A61L15/225

摘要： A process of making a wound dressing is suggested, in which a technical conventional viscose solution is mixed with a polysaccharide derivative; the mixture is treated at increased temperatures such that it is thermally coagulated; the coagulate is wetted with a polyalkylene glycol and dried, whereby a particulate structure of the wound dressing is produced.

摘要翻译： 建议制造伤口敷料的方法，其中将技术常规粘胶溶液与多糖衍生物混合; 混合物在升高的温度下进行处理，使其热凝固; 用聚亚烷基二醇润湿凝结物并干燥，由此制备伤口敷料的颗粒结构。

公开(公告)号：US3959236A

公开(公告)日：1976-05-25

申请号：US495641

申请日：1974-08-08

申请人： Jan Peska ,  Milan Benes ,  Jiri Stamberg

发明人： Jan Peska ,  Milan Benes ,  Jiri Stamberg

IPC分类号： C08F2/00 ,  B01D71/40 ,  B01J20/22 ,  C08F2/02 ,  C08F2/04 ,  C08F2/18 ,  C08F20/00 ,  C08F20/10 ,  C08F20/38 ,  C08F28/02 ,  C08G75/24

CPC分类号： B01D71/40 ,  B01J20/22 ,  C08F20/38 ,  Y10S526/923

摘要： The invention relates to chemically reactive polymers and copolymers of hydroxyalkyl methacrylate sulfo esters with monomer units of the formula ##EQU1## where n is an integer equal to 1 or 2 and R is C.sub.6 H.sub.5 --, p--CH.sub.3 C.sub.6 H.sub.4 --, or CH.sub.3 -- and to the method of manufacturing the technically useful articles from these polymers, namely crosslinked beads, membranes, blocks, etc., by free-radical polymerization or copolymerization in bulk, solution or in two-phase aqueous dispersion system under conditions whereby the hydrolysis of the sulfo ester is suppressed.

摘要翻译： 本发明涉及甲基丙烯酸羟烷基酯磺酸酯与式CH 3 | -CH 2-C≡CO-（ - O-CH 2 -CH 2）n -SO 2 -R的单体单元的化学反应性聚合物和共聚物，其中n是等于 至1或2并且R为C 6 H 5 - ，p -CH 3 C 6 H 4 - 或CH 3 - ，以及通过自由基聚合或共聚制备由这些聚合物即交联珠粒，膜，嵌段等技术上有用的制品的方法 在本体，溶液中或在两相水分散系统中，在抑制磺基酯水解的条件下。

公开(公告)号：US4794177A

公开(公告)日：1988-12-27

申请号：US809929

申请日：1985-12-16

申请人： Jan Peska ,  Jiri Lenfeld ,  Zedenek Plichta ,  Milan Benes ,  Frantisek Svec ,  Jiri Coupek

发明人： Jan Peska ,  Jiri Lenfeld ,  Zedenek Plichta ,  Milan Benes ,  Frantisek Svec ,  Jiri Coupek

IPC分类号： C08L5/00 ,  B01J20/22 ,  B01J20/281 ,  B01J20/291 ,  C08B37/02 ,  C08L5/02 ,  G01N30/88 ,  B01D15/08 ,  C02F1/28

CPC分类号： B01J20/291 ,  B01J20/22 ,  C08B37/0021 ,  B01J2220/54

摘要： The invention pertains to a method for the production of bead dextran materials for gel chromatography.The subject of the invention is a method for the production of bead dextran materials for gel chromatography, wherein dextran is, before or during the suspension process or in both stages, subjected to reduction in an alkaline solution, advantageously by the action of sodium borohydride, whereas the density of crosslinking is controlled above all by variation of the concentration of the initial dextran solution and the resulting gel may be optionally subjected to the additional crosslinking in a separate subsequent operation.The procedure according to the invention provides the product of higher quality with a lower content of carboxylic groups and substantially facilitates the preparation of gels with a very high and a very low crosslink density.

摘要翻译： 本发明涉及一种生产凝胶色谱用珠粒葡聚糖材料的方法。 本发明的主题是用于制备用于凝胶色谱法的珠粒葡聚糖材料的方法，其中右旋糖酐在悬浮过程之前或期间或两个阶段都经受碱性溶液的还原，有利的是通过硼氢化钠的作用， 而交联的密度首先通过初始葡聚糖溶液的浓度的变化来控制，并且所得到的凝胶可以任选地在单独的随后操作中进行额外的交联。 根据本发明的方法提供了具有较低含量的羧基的较高质量的产品，并且基本上有助于制备具有非常高且非常低的交联密度的凝胶。

公开(公告)号：US4105858A

公开(公告)日：1978-08-08

申请号：US700308

申请日：1976-06-28

申请人： Milan Benes ,  Jan Peska

发明人： Milan Benes ,  Jan Peska

IPC分类号： C02F1/54 ,  C07D213/20 ,  C07D213/82 ,  C07D215/10 ,  C07D277/22 ,  C07D277/24 ,  C08F20/34 ,  C08F28/00

CPC分类号： C07D213/20 ,  C02F1/54 ,  C07D213/82 ,  C07D215/10 ,  C07D277/22 ,  C07D277/24 ,  C08F20/34 ,  C08F28/00

摘要： The invention relates to quaternary cationic monomers and polymers and copolymers prepared thereof, based upon salts of methacrylic or acrylic esters of the general formula I ##STR1## where R.sup.1 is H or CH.sub.3R.sup.2 is CH.sub.3, C.sub.6 H.sub.5 or p-CH.sub.3 C.sub.6 H.sub.4n is 1 or 2AndY.sup.+ is --N.sup.+ (CH.sub.3).sub.3, --N.sup.+ (CH.sub.3).sub.2 CH.sub.2 CH.sub.2 OH, ##STR2## where R.sup.3 is H, CH.sub.3, CONH.sub.2, CHO, COCH.sub.3andR.sup.4 is H or CH.sub.2 CH.sub.2 OH.The invention further relates to some methods for preparation of monomers, polymers and copolymers of the aforegiven salts. The polymers and copolymers exhibit the properties of polyelectrolytes and ion exchange resins.

摘要翻译： 本发明涉及季铵阳离子单体及其制备的聚合物和共聚物，其基于通式I的甲基丙烯酸或丙烯酸酯盐，其中R 1为H或CH 3 R 2为CH 3，C 6 H 5或p -CH 3 C 6 H 4 n为1或 2和Y +是-N +（CH 3）3，-N +（CH 3）2 CH 2 CH 2 OH，其中R 3是H，CH 3，CONH 2，CHO，COCH 3和R 4是H或CH 2 CH 2 OH。

公开(公告)号：US4077963A

公开(公告)日：1978-03-07

申请号：US725150

申请日：1976-09-20

申请人： Milan Benes ,  Jan Peska

发明人： Milan Benes ,  Jan Peska

IPC分类号： C02F1/54 ,  C07D213/20 ,  C07D213/82 ,  C07D215/10 ,  C07D277/22 ,  C07D277/24 ,  C08F20/34 ,  C08F28/00 ,  C07D213/89

CPC分类号： C07D213/20 ,  C02F1/54 ,  C07D213/82 ,  C07D215/10 ,  C07D277/22 ,  C07D277/24 ,  C08F20/34 ,  C08F28/00

摘要： The invention relates to quaternary cationic monomers and polymers and copolymers prepared thereof, based upon salts of methacrylic or acrylic esters of the general formula I ##STR1## where R.sup.1 is H or CH.sub.3R.sup.2 is CH.sub.3, C.sub.6 H.sub.5 or p-CH.sub.3 C.sub.6 H.sub.4n is 1 or 2AndY.sup.+ is --N.sup.+ (CH.sub.3).sub.3, --N.sup.+ (CH.sub.3).sub.2 CH.sub.2 CH.sub.2 OH, ##STR2## where R.sup.3 is H, CH.sub.3, CONH.sub.2, CHO, COCH.sub.3andR.sup.4 is H or CH.sub.2 CH.sub.2 OH.The invention further relates to some methods for preparation of monomers, polymers and copolymers of the aforegiven salts. The polymers and copolymers exhibit the properties of polyelectrolytes and ion exchange resins.

摘要翻译： 本发明涉及季铵阳离子单体及其制备的聚合物和共聚物，其基于通式I的甲基丙烯酸或丙烯酸酯盐，其中R 1为H或CH 3 R 2为CH 3，C 6 H 5或p -CH 3 C 6 H 4 n为1或 2和Y +是-N +（CH 3）3，-N +（CH 3）2 CH 2 CH 2 OH，其中R 3是H，CH 3，CONH 2，CHO，COCH 3和R 4是H或CH 2 CH 2 OH。

公开(公告)号：US4055510A

公开(公告)日：1977-10-25

申请号：US579716

申请日：1975-05-21

申请人： Jan Peska ,  Jiri Stamberg ,  Zdenko Blace

发明人： Jan Peska ,  Jiri Stamberg ,  Zdenko Blace

IPC分类号： C08L1/00 ,  B01J2/00 ,  B01J13/00 ,  C08J3/12 ,  C08J3/14 ,  C08J3/16 ,  C08L7/00 ,  C08L21/00 ,  B01J37/00 ,  B01D3/00

CPC分类号： C08J3/16 ,  B01J13/0065 ,  B01J2/00 ,  C08K5/0025 ,  C08K5/15 ,  C08J2301/24

摘要： The invention relates to a method for manufacturing of spherical cellulose particles in bead form which enables to control the partial shape and porosity of the particles. Resulting cellulose sorbents are suitable carriers and materials for chromatography. The invented methods consists in heating a viscose (an aqueous solution of sodium cellulose xanthate) suspension in a water-immiscible liquid to 30.degree.-100.degree. C under stirring to form spherical droplets and solidify them and in the subsequent acidic decomposition of the solid xanthate globules either directly by addition of an acid soluble in the dispersion medium, or additionally after isolation and eventual washing of the particles to achieve the required wet volume. Liquids with the viscosity up to 100 cSt are advantageously used as dispersion medium and surfactants and/or modifying reagents (e.g. epichlorohydrine) may be added to the suspension.

摘要翻译： 本发明涉及一种珠粒形球形纤维素颗粒的制造方法，其能够控制颗粒的部分形状和孔隙率。 得到的纤维素吸附剂是适用于色谱的载体和材料。 本发明的方法是在搅拌下将粘性纤维素（黄原酸钠纤维素钠水溶液）悬浮液加热至30〜-100℃，形成球形液滴并使其固化，随后固体黄原酸酸性分解 直接通过加入可溶于分散介质中的酸，或另外分离并最终洗涤颗粒以达到所需的湿体积。 粘度高达100cSt的液体有利地用作分散介质，并且可以向悬浮液中加入表面活性剂和/或改性试剂（例如表氯醇）。