公开(公告)号：US09152823B2

公开(公告)日：2015-10-06

申请号：US11112758

申请日：2005-04-22

申请人： Maxim S. Shatskih ,  James Kirby ,  Scott Barnes

发明人： Maxim S. Shatskih ,  James Kirby ,  Scott Barnes

IPC分类号： G06F12/00 ,  G06F13/00 ,  G06F13/28 ,  G06F21/78 ,  G06F3/06

CPC分类号： G06F21/78 ,  G06F3/0601 ,  G06F2003/0697

摘要： The present invention comprises computing systems, computer readable media, and methods of protecting computing systems. Embodiments comprise defining a virtual volume, mounting the virtual volume, and processing write accesses. Processing write accesses comprises creating a virtual volume record in a virtual volume database associated with the write access and storing write data at a free location of a shadow cache. Embodiments may also include processing read accesses comprising comparing the read accesses to a virtual volume record to determine if a matching virtual volume record exists, reading data from the target volume if the matching virtual volume record is absent, and reading a data from the shadow cache if the matching virtual volume record is present. Embodiments may also comprise processing at least one virtual volume record upon the occurrence of an event of interest and includes copying a cache data segment from the shadow cache to the target volume.

摘要翻译： 本发明包括计算系统，计算机可读介质和保护计算系统的方法。 实施例包括定义虚拟卷，安装虚拟卷，以及处理写访问。 处理写访问包括在与写访问相关联的虚拟卷数据库中创建虚拟卷记录，并且在影子高速缓存的空闲位置存储写数据。 实施例还可以包括处理读取访问，包括将读访问与虚拟卷记录进行比较，以确定是否存在匹配的虚拟卷记录，如果匹配的虚拟卷记录不存在则从目标卷读取数据，以及从阴影缓存读取数据 如果匹配的虚拟卷记录存在。 实施例还可以包括在感兴趣的事件发生时处理至少一个虚拟卷记录，并且包括将高速缓存数据段从影子缓存复制到目标卷。

公开(公告)号：US07921652B2

公开(公告)日：2011-04-12

申请号：US11812922

申请日：2007-06-22

申请人： Stuart James Kirby

发明人： Stuart James Kirby

IPC分类号： F02C6/04

CPC分类号： F01D17/105 ,  F02C6/08 ,  F02C9/18 ,  F02K3/075 ,  F05D2250/241 ,  F05D2250/314 ,  F05D2250/52

摘要： A bleed valve (30) for a gas turbine engine (10) comprises a diffuser (50), through which heated compressor bleed air flows (54) into a bypass duct (22) air stream (B), has a plurality of small holes (40). The plurality of holes (40) is divided into two or more arrays of holes (52p,q,r), each array of holes (52p,q,r) is angled (δ) away from one another so that their respective bleed flows (54p,q,r) do not coalesce. This separation improves mixing with the air stream (B) and helps prevent hot bleed air damaging nacelle and other engine components.

摘要翻译： 用于燃气涡轮发动机（10）的排放阀（30）包括扩散器（50），加热的压缩机排出空气流过该扩散器（54）进入旁通管道（22）空气流（B），具有多个小孔 （40）。 多个孔（40）被分成两个或更多个孔阵列（52p，q，r），每个孔阵列（52p，q，r）彼此成角度（δ），使得它们各自的流出流 （54p，q，r）不合并。 这种分离改善了与空气流（B）的混合，并有助于防止热空气损坏的机舱和其他发动机部件。

公开(公告)号：US20080299290A1

公开(公告)日：2008-12-04

申请号：US11660341

申请日：2005-08-16

申请人： Andrew James Kirby

发明人： Andrew James Kirby

IPC分类号： A61M25/06

CPC分类号： B81C1/00111 ,  A61M37/0015 ,  A61M2037/0053 ,  B29C37/0053 ,  B29C64/135 ,  B29C2035/0827 ,  B29L2031/759 ,  B33Y80/00 ,  B81B2201/055

摘要： A method of manufacturing microneedles is provided, the method includes (i) depositing a substance onto a first surface and (ii) forming a solid needle-like shape from the substance. The substance may be deposited in non-solid form and subsequently solidified. A method provides an array of such microneedles.

摘要翻译： 提供了制造微针的方法，该方法包括（i）将物质沉积到第一表面上，和（ii）从该物质形成固体针状形状。 该物质可以以非固体形式沉积并随后固化。 一种方法提供这种微针的阵列。

公开(公告)号：US20060060281A1

公开(公告)日：2006-03-23

申请号：US10947896

申请日：2004-09-23

申请人： James Kirby

发明人： James Kirby

IPC分类号： B60C17/00

CPC分类号： B60C17/0009 ,  B60C17/0027 ,  Y10T152/10864

摘要： A pneumatic tire in accordance with an exemplary embodiment of the invention includes a tread portion having a pair of lateral tread edges, a pair of bead portions, a pair of sidewalls that each extend radially from one of the lateral tread edges of the tread portion to one of the bead portions, an inner liner, and a pair of sidewall inserts. Each of the sidewall inserts is disposed between one of the sidewalls and the inner liner. Each of the sidewall inserts includes a top portion and a bottom portion that are each made of high modulus, low hysteresis run-flat stock. Each of the sidewall inserts also includes a center portion made of sidewall stock disposed between the top and bottom portions.

摘要翻译： 根据本发明的示例性实施例的充气轮胎包括胎面部分，其具有一对侧向胎面边缘，一对胎圈部分，一对侧壁，每个侧壁从胎面部分的一个胎面侧缘径向延伸至 胎圈部分之一，内衬和一对胎侧插件。 每个侧壁插入物设置在侧壁之一和内衬之间。 每个侧壁插入件包括顶部和底部，每个顶部和底部由高模量，低滞后的扁平坯料制成。 每个侧壁插入件还包括由设置在顶部和底部之间的侧壁坯料制成的中心部分。

公开(公告)号：US20110112502A1

公开(公告)日：2011-05-12

申请号：US12673896

申请日：2008-10-06

申请人： Andrew James Kirby

发明人： Andrew James Kirby

IPC分类号： A61M5/30

CPC分类号： A61M37/0069 ,  A61B17/205 ,  A61B2017/00345 ,  A61M2037/0007

摘要： A needleless device (10) for delivery of an agent through a biological barrier, the device comprising a microimplant (12) retaining layer (13) holding at least one microimplant for delivery through the biological barrier, a microimplant driving layer including means (21) for providing a motive force to the or each microimplant, and a guide layer having at least one guide channel associated with a microimplant through which the motive force is applied to the or each microimplant, wherein, in use, activation of the microimplant driving layer causes the or each microimplant to be driven away from the retaining layer through the biological barrier.

摘要翻译： 一种用于通过生物屏障递送药剂的无针装置（10），所述装置包括保持至少一个微型植入物用于通过生物屏障输送的微量植入物（12）保持层（13），包括装置（21）的微型植入物驱动层， 用于向所述或每个微型植入物提供动力，以及引导层，其具有与微型植入物相关联的至少一个引导通道，通过所述导向通道将所述动力施加到所述微型植入物或每种微型植入物，其中在使用中，所述微型植入物驱动层的激活导致 所述或每个微型植入物通过生物屏障被驱离离保留层。

公开(公告)号：US20090053797A1

公开(公告)日：2009-02-26

申请号：US12063831

申请日：2006-08-17

申请人： Yoichiro Shiba ,  James Kirby ,  Eric M. Paradise ,  Jay D. Keasling

发明人： Yoichiro Shiba ,  James Kirby ,  Eric M. Paradise ,  Jay D. Keasling

IPC分类号： C12N1/19

CPC分类号： C12P23/00

摘要： The present invention provides genetically modified eukaryotic host cells exhibiting increased activity levels of one or more enzymes that generate precursors to be utilized by the mevalonate pathway enzymes, increased activity levels of one or more mevalonate pathway enzymes, prenyl transferase, and/or decreased levels of squalene synthase activity; such cells are useful for producing isoprenoid compounds. The present invention provides genetically modified eukaryotic host cells that produce higher levels of acetyl-CoA than a control cell; such cells are useful for producing a variety of products, including isoprenoid compounds. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.

摘要翻译： 本发明提供遗传修饰的真核宿主细胞，其表现出增加的活性水平的一种或多种酶，其产生由甲羟戊酸途径酶利用的前体，增加一种或多种甲羟戊酸途径酶的活性水平，异戊烯基转移酶和/或降低的水平 角鲨烯合酶活性; 这样的细胞可用于产生类异戊二烯化合物。 本发明提供了比对照细胞产生更高水平的乙酰辅酶A的经遗传修饰的真核宿主细胞; 这样的细胞可用于生产各种产品，包括类异戊二烯化合物。 提供了用于在受试者遗传修饰的真核宿主细胞中产生类异戊二烯化合物或类异戊二烯前体的方法。 所述方法通常涉及在促进产生高水平的类异戊二烯或类异戊二烯前体化合物的条件下培养受试者遗传修饰的宿主细胞。

公开(公告)号：US06584727B1

公开(公告)日：2003-07-01

申请号：US10131312

申请日：2002-04-23

申请人： Richard Frank De Shazer ,  James Kirby Smith

发明人： Richard Frank De Shazer ,  James Kirby Smith

IPC分类号： A01K9705

CPC分类号： A01K97/05

摘要： A live bait container for wade fishing and trolling comprises a hollow cylindrical shell with an integral bottom and a modified frustrum of a right cylinder forming the top. An access opening and cover assembly is disposed on the front face of the container. The container shall have a main and a top buoyancy chamber disposed to maintain the bait chamber submerged while keeping the access opening above water. The container's midsection, including the sloping back shall be plastic mesh. Other material used in the construction, except the access cover assembly, is generally of transparent plastic enabling the bait to be observed. The removable access cover assembly comprises a plurality of elastic strips with a retaining device on both ends that engage the container. Bait is recovered by reaching between the elastic strips. The container has a keel containing a handhold for carrying and a hole for a two line.

摘要翻译： 用于钓鱼和拖钓的活饵容器包括具有整体底部的中空圆柱形壳体和形成顶部的右圆柱体的改进的膛孔。 入口开口和盖组件设置在容器的前表面上。 容器应具有主和顶部浮力室，其设置为在将进入开口保持在水面上方时将饵料室淹没。 容器的中部，包括倾斜的背面应为塑料网。 用于建筑中的其他材料，除了进入盖组件，通常是透明塑料，使得能够观察到诱饵。 可移除的接近盖组件包括多个弹性带，其两端具有接合容器的保持装置。 通过到达弹性带之间来回收饵料。 容器具有龙骨，其具有用于承载的扶手和用于两条线的孔。

公开(公告)号：US09382553B2

公开(公告)日：2016-07-05

申请号：US13587826

申请日：2012-08-16

申请人： James Kirby ,  Jeffrey L. Fortman ,  Minobu Nishimoto ,  Jay D. Keasling

发明人： James Kirby ,  Jeffrey L. Fortman ,  Minobu Nishimoto ,  Jay D. Keasling

IPC分类号： C12N1/21 ,  C12N9/04 ,  C12P19/02 ,  C12P5/00

CPC分类号： C12P19/02 ,  C12N9/0006 ,  C12P5/007 ,  Y02P20/52

摘要： The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12), and optionally one or more DXP derived compounds, comprising: (a) a mutant RibB, or functional variant thereof, capable of catalyzing xylulose 5-phosphate and/or ribulose 5-phosphate to DXP, or (b) a YajO, or functional variant thereof, and a XylB, or functional variant thereof.

摘要翻译： 本发明提供能够产生1-脱氧纤维素5-磷酸或1-脱氧-D-木酮糖-5-磷酸（DXP）（12）以及任选的一种或多种DXP衍生化合物的经遗传修饰的宿主细胞，其包含：（a ）能够将木酮糖-5-磷酸和/或核酮糖5-磷酸催化成DXP的突变体RibB或其功能变体，或（b）YajO或其功能变体和XylB或其功能变体。

公开(公告)号：US08930889B2

公开(公告)日：2015-01-06

申请号：US13766024

申请日：2013-02-13

申请人： James Kirby, Jr.

发明人： James Kirby, Jr.

IPC分类号： G06F9/44

CPC分类号： G06F8/20 ,  G06F8/10

摘要： A device for modeling a software application includes an environmental model that includes a first set of attributes. The first set of attributes includes a value attribute, a declaration, and a set of meta-attributes. A behavioral model includes a second set of attributes, including a portion of the first set of attributes, wherein the environmental and behavioral models share the portion. The second set of attributes includes a value attribute and set of meta-attributes, each having at least one of a declaration and function. Changes to an attribute in the behavioral model reflect in all models that share the attribute. A design model includes a first decomposition of the second set of attributes into a first plurality of groups. A run-time model includes a second decomposition of the second set of attributes into a second plurality of groups, and records the decomposition of the behavioral model into run-time components.

摘要翻译： 用于对软件应用建模的设备包括包括第一组属性的环境模型。 第一组属性包括值属性，声明和一组元属性。 行为模型包括第二组属性，包括第一组属性的一部分，其中环境和行为模型共享该部分。 第二组属性包括一个值属性和一组元属性，每一个具有声明和功能中的至少一个。 行为模型中属性的更改反映在共享属性的所有模型中。 设计模型包括将第二组属性首先分解成第一组多个组。 运行时模型包括将第二组属性的第二分解分解成第二组，并将行为模型的分解记录到运行时分量中。

公开(公告)号：US08828684B2

公开(公告)日：2014-09-09

申请号：US11571315

申请日：2005-07-21

申请人： Jay D. Keasling ,  James Kirby ,  Eric M. Paradise

发明人： Jay D. Keasling ,  James Kirby ,  Eric M. Paradise

IPC分类号： C12N15/79 ,  C12N15/80 ,  C12N1/15 ,  C12N1/19 ,  C12P23/00 ,  C12N15/81 ,  C12P5/00 ,  C12N9/10

CPC分类号： C12P5/007 ,  C12N9/0006 ,  C12N9/1085 ,  C12N9/88 ,  C12N15/81 ,  C12P23/00 ,  C12Y101/01034 ,  C12Y205/01092 ,  C12Y402/03024

摘要： The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.

摘要翻译： 本发明提供了产生类异戊二烯前体或类异戊二烯化合物的遗传修饰的真核宿主细胞。 受试者遗传修饰的宿主细胞包括增加一种或多种甲羟戊酸途径酶的活性水平，异丙烯基转移酶活性水平升高和角鲨烯合酶活性水平降低。 提供了用于在受试者遗传修饰的真核宿主细胞中产生类异戊二烯化合物或类异戊二烯前体的方法。 所述方法通常涉及在促进产生高水平的类异戊二烯或类异戊二烯前体化合物的条件下培养受试者遗传修饰的宿主细胞。