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    Methods of Preparing Quinoline Derivatives
    2.
    发明申请
    Methods of Preparing Quinoline Derivatives 审中-公开
    喹啉衍生物的制备方法

    公开(公告)号：US20130030172A1

    公开(公告)日：2013-01-31

    申请号：US13132650

    申请日：2009-12-04

    Applicant: Jo Ann Wilson ,  Sharique Zuberi ,  Erick Goldman ,  James Kanter

    Inventor： Jo Ann Wilson ,  Sharique Zuberi ,  Erick Goldman ,  James Kanter

    IPC: C07D413/12

    CPC classification number: C07D215/233

    Abstract: Methods of preparing compounds of formula i(1): or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 join together with the nitrogen atom to which they are attached to form a 6 membered heterocycloalkyl group; X1 is H, Br, Cl or F; X2 is H, Br, Cl or F; s is 2-6; n1 is 0-2; and n2 is 0-2.

    Abstract translation: 制备式I（1）化合物的方法：或其药学上可接受的盐，其中：R 1和R 2与它们所连接的氮原子一起形成6元杂环烷基; X1为H，Br，Cl或F; X2是H，Br，Cl或F; s是2-6; n1为0-2; n2为0-2。

    Synthesis of 2-acyl substituted chromanes and intermediates thereof
    7.
    发明授权
    Synthesis of 2-acyl substituted chromanes and intermediates thereof 失效
    2-酰基取代的苯并吡喃的合成及其中间体

    公开(公告)号：US06903227B2

    公开(公告)日：2005-06-07

    申请号：US10297103

    申请日：2001-06-01

    Applicant: James Kanter ,  John J. G. Mullins ,  Anjali Pandey ,  Robert Scarborough

    Inventor： James Kanter ,  John J. G. Mullins ,  Anjali Pandey ,  Robert Scarborough

    IPC: C07D311/22 ,  C07D311/58 ,  C12P17/06

    CPC classification number: C07D311/58 ,  C07D311/22

    Abstract: Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors are disclosed. Further disclosed are processes for producing salts such as acid addition salts for such enantiomerically enriched compositions.

    Abstract translation: 公开了用于产生2-酰基取代的色烯化合物的对映体富集和对映体纯的组合物的新方法和作为制备血小板聚集抑制剂的中间体和/或本身是有效的血小板聚集抑制剂的2-酰基苯并二氢吡喃化合物。 进一步公开的是制备盐的方法，例如这种对映异构体富集的组合物的酸加成盐。

    NITROGENOUS HETEROCYCLIC COMPOUNDS AND PROCESS FOR MAKING NITROGENOUS HETEROCYCLIC COMPOUNDS AND INTERMEDIATES THEREOF
    9.
    发明申请
    NITROGENOUS HETEROCYCLIC COMPOUNDS AND PROCESS FOR MAKING NITROGENOUS HETEROCYCLIC COMPOUNDS AND INTERMEDIATES THEREOF 失效
    氮杂环化合物和制备氮杂环化合物的方法及其中间体

    公开(公告)号：US20100240893A1

    公开(公告)日：2010-09-23

    申请号：US12622411

    申请日：2009-11-19

    Applicant: James Kanter ,  Anjali Pandey ,  James Robinson ,  Robert M. Scarborough

    Inventor： James Kanter ,  Anjali Pandey ,  James Robinson ,  Robert M. Scarborough

    IPC: C07D295/215

    CPC classification number: C07D239/94

    Abstract: The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof.

    Abstract translation: 本发明提供含氮杂环化合物及其药学上可接受的盐及其制备方法。 这些化合物对抑制这种激酶活性的激酶的磷酸化具有抑制活性。 本发明还提供了可用于该方法的中间体化合物，以及通过该方法生产的最终产物及其盐或前药。 本发明进一步提供了通过抑制激酶的磷酸化来抑制哺乳动物激酶和治疗疾病状态的方法，包括向有需要的患者施用有效量的本发明化合物。

    Nitrogenous heterocyclic compounds and process for making nitrogenous heterocyclic compounds and intermediates thereof
    10.
    再颁专利
    Nitrogenous heterocyclic compounds and process for making nitrogenous heterocyclic compounds and intermediates thereof 失效
    含氮杂环化合物及其制备含氮杂环化合物的方法及其中间体

    公开(公告)号：USRE43098E1

    公开(公告)日：2012-01-10

    申请号：US11866275

    申请日：2007-10-02

    Applicant: James Kanter ,  Anjali Pandey ,  James Robinson ,  Robert M. Scarborough ,  Carroll Scarborough, legal representative

    Inventor： James Kanter ,  Anjali Pandey ,  James Robinson ,  Robert M. Scarborough

    IPC: A61K31/495 ,  C07D487/00 ,  C07D487/04 ,  C07D239/94

    Abstract: The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof.

    Abstract translation: 本发明提供了含氮杂环化合物及其药学上可接受的盐及其制备方法。 这些化合物对抑制这种激酶活性的激酶的磷酸化具有抑制活性。 本发明还提供了可用于该方法的中间体化合物，以及通过该方法生产的最终产物及其盐或前药。 本发明进一步提供了通过抑制激酶的磷酸化来抑制哺乳动物激酶和治疗疾病状态的方法，包括向有需要的患者施用有效量的本发明化合物。

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