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1.发明授权4-amino-1H-pyrimidin-2-one based compounds, compositions comprising them and methods of their use 有权4-氨基-1H-嘧啶-2-酮基化合物，包含它们的组合物及其使用方法公开(公告)号：US08093245B2
公开(公告)日：2012-01-10
申请号：US11954421
申请日：2007-12-12
申请人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Alexander Heim-Riether , Theodore C. Jessop , James E. Tarver , Jerry A. Taylor
发明人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Alexander Heim-Riether , Theodore C. Jessop , James E. Tarver , Jerry A. Taylor
IPC分类号： C07D239/47 , C07D403/04 , A61K31/506
CPC分类号： C07D239/47 , C07D239/54 , C07D403/04 , C07D403/08 , C07D403/12 , C07D405/12 , C07D409/14 , C07D417/12 , C07D471/04
摘要： 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了4-氨基-1H-嘧啶-2-酮基化合物，包含它们的组合物及其用于治疗，预防和治疗各种疾病和病症的方法。 特定的化合物具有式I：
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公开(公告)号：US08153804B2
公开(公告)日：2012-04-10
申请号：US11497539
申请日：2006-07-31
申请人： David J. Augeri , James E. Tarver, Jr. , Qinghong Fu , Michael Victor Voronkov , Doan Hackley , Michael E. Mertzman , Marianne Carlsen
发明人： David J. Augeri , James E. Tarver, Jr. , Qinghong Fu , Michael Victor Voronkov , Doan Hackley , Michael E. Mertzman , Marianne Carlsen
IPC分类号： C07D213/38 , C07D417/10 , C07D401/04 , C07D401/10 , C07D213/73 , A61P35/00
CPC分类号： C07D401/04 , C07D213/73 , C07D401/10 , C07D417/10
摘要： Aryl pyridines, compositions comprising them, and methods of their use for the treatment, prevention and management of a variety of diseases and disorders are disclosed.
摘要翻译： 公开了芳基吡啶，包含它们的组合物及其用于治疗，预防和治疗各种疾病和病症的方法。
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3.发明授权O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer 有权O-连接的嘧啶-4-胺类化合物，包含它们的组合物及其用于治疗癌症的方法公开(公告)号：US08093246B2
公开(公告)日：2012-01-10
申请号：US11954433
申请日：2007-12-12
申请人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
发明人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
IPC分类号： C07D403/14 , A61K31/506
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I:
摘要翻译： 描述了O-连接的嘧啶-4-胺类化合物，包含它们的药物组合物及其使用方法。 本发明的具体化合物具有式I：
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4.发明授权Heterocyclic compounds, compositions comprising them and methods of their use 有权杂环化合物，包含它们的组合物及其使用方法公开(公告)号：US07825142B2
公开(公告)日：2010-11-02
申请号：US12545954
申请日：2009-08-24
申请人： David J. Augeri , Jeffrey Bagdanoff , Simon D. P. Baugh , Kenneth G. Carson , Theodore C. Jessop , James E. Tarver
发明人： David J. Augeri , Jeffrey Bagdanoff , Simon D. P. Baugh , Kenneth G. Carson , Theodore C. Jessop , James E. Tarver
IPC分类号： A61K31/426 , A61K31/42 , A61K31/4155 , A61K31/4178 , C07D277/20 , C07D413/04 , C07D249/14 , C07D231/14 , C07D233/88
CPC分类号： C07D403/04 , C07D413/04 , C07D417/04
摘要： Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了杂环化合物，包含它们的组合物及其用于治疗，预防和治疗炎性和自身免疫疾病和病症的方法。 特定的化合物具有式I：
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5.发明申请HETEROCYCLIC COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE 有权杂环化合物，包含它们的组合物及其使用方法公开(公告)号：US20090312375A1
公开(公告)日：2009-12-17
申请号：US12545954
申请日：2009-08-24
申请人： David J. Augeri , Jeffrey Bagdanoff , Simon D.P. Baugh , Kenneth G. Carson , Theodore C. Jessop , James E. Tarver
发明人： David J. Augeri , Jeffrey Bagdanoff , Simon D.P. Baugh , Kenneth G. Carson , Theodore C. Jessop , James E. Tarver
IPC分类号： A61K31/427 , A61K31/422 , A61K31/4196 , A61K31/415 , C07D415/00 , C07D413/04 , C07D403/04 , C07D233/54
CPC分类号： C07D403/04 , C07D413/04 , C07D417/04
摘要： Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了杂环化合物，包含它们的组合物及其用于治疗，预防和治疗炎性和自身免疫疾病和病症的方法。 特定的化合物具有式I：
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6.发明授权Heterocyclic compounds, compositions comprising them and methods of their use 有权杂环化合物，包含它们的组合物及其使用方法公开(公告)号：US07598280B2
公开(公告)日：2009-10-06
申请号：US12038872
申请日：2008-02-28
申请人： David J. Augeri , Jeffrey Bagdanoff , Simon D. P. Baugh , Kenneth G. Carson , Theodore C. Jessop , James E. Tarver
发明人： David J. Augeri , Jeffrey Bagdanoff , Simon D. P. Baugh , Kenneth G. Carson , Theodore C. Jessop , James E. Tarver
IPC分类号： C07D277/20 , C07D261/06 , C07D249/14 , C07D261/04 , C07D403/04 , A61K31/426 , A61K31/422 , A61K31/4178
CPC分类号： C07D403/04 , C07D413/04 , C07D417/04
摘要： Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了杂环化合物，包含它们的组合物及其用于治疗，预防和治疗炎性和自身免疫疾病和病症的方法。 特定的化合物具有式I：
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7.发明申请公开(公告)号：US20090030050A1
公开(公告)日：2009-01-29
申请号：US12038872
申请日：2008-02-28
申请人： David J. Augeri , Jeffrey Bagdanoff , Simon D.P. Baugh , Kenneth G. Carson , Theodore C. Jessop , James E. Tarver
发明人： David J. Augeri , Jeffrey Bagdanoff , Simon D.P. Baugh , Kenneth G. Carson , Theodore C. Jessop , James E. Tarver
IPC分类号： A61K31/427 , C07D413/04 , C07D417/04 , C07D403/04 , A61P3/10 , A61K31/4196 , A61K31/422
CPC分类号： C07D403/04 , C07D413/04 , C07D417/04
摘要： Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了杂环化合物，包含它们的组合物及其用于治疗，预防和治疗炎性和自身免疫疾病和病症的方法。 特定的化合物具有式I：
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8.发明申请4-AMINO-1H-PYRIMIDIN-2-ONE BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE 有权4-氨基-1H-吡嗪二酮化合物，包含它们的组合物及其使用方法公开(公告)号：US20080182847A1
公开(公告)日：2008-07-31
申请号：US11954421
申请日：2007-12-12
申请人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Alexander Heim-Riether , Theodore C. Jessop , James E. Tarver , Jerry A. Taylor
发明人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Alexander Heim-Riether , Theodore C. Jessop , James E. Tarver , Jerry A. Taylor
IPC分类号： A61K31/517 , A61K31/513 , C07D403/02
CPC分类号： C07D239/47 , C07D239/54 , C07D403/04 , C07D403/08 , C07D403/12 , C07D405/12 , C07D409/14 , C07D417/12 , C07D471/04
摘要： 4-Amino-1H-pyrimidin-2-one-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of various diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了4-氨基-1H-嘧啶-2-酮基化合物，包含它们的组合物及其用于治疗，预防和治疗各种疾病和病症的方法。 特定的化合物具有式I：
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9.发明申请O-LINKED PYRIMIDIN-4-AMINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE TO TREAT CANCER 有权O型连接的吡啶基-4-胺基化合物，包含它们的组合物及其用于治疗癌症的方法公开(公告)号：US20080146571A1
公开(公告)日：2008-06-19
申请号：US11954433
申请日：2007-12-12
申请人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
发明人： David J. Augeri , Marianne Carlsen , Kenneth G. Carson , Qinghong Fu , Jason P. Healy , Alexander Heim-Riether , Theodore C. Jessop , Philip E. Keyes , Min Shen , James E. Tarver , Jerry A. Taylor , Xiaolian Xu
IPC分类号： A61K31/506 , C07D239/47 , C07D403/12 , A61K31/519 , A61P35/00 , A61K31/5377 , C07D491/044 , C07D413/12
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I:
摘要翻译： 描述了O-连接的嘧啶-4-胺类化合物，包含它们的药物组合物及其使用方法。 本发明的具体化合物具有式I：
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10.发明申请公开(公告)号：US20110082178A1
公开(公告)日：2011-04-07
申请号：US12903657
申请日：2010-10-13
申请人： David J. Augeri , Jeffrey Bagdanoff , Simon D.P. Baugh , Kenneth G. Carson , Theodore C. Jessop , James E. Tarver
发明人： David J. Augeri , Jeffrey Bagdanoff , Simon D.P. Baugh , Kenneth G. Carson , Theodore C. Jessop , James E. Tarver
IPC分类号： A61K31/422 , A61K31/427 , A61K31/4196 , A61K31/4178 , A61P29/00 , A61P37/00 , A61P37/06 , A61P11/06 , A61P25/00 , A61P21/04 , A61P17/06 , A61P19/02 , A61P3/10
CPC分类号： C07D403/04 , C07D413/04 , C07D417/04
摘要： Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
摘要翻译： 公开了杂环化合物，包含它们的组合物及其用于治疗，预防和治疗炎性和自身免疫疾病和病症的方法。 特定的化合物具有式I：
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