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公开(公告)号：US11230526B1
公开(公告)日：2022-01-25
申请号：US16977828
申请日：2019-03-05
发明人： James C. Lanter , Mark J. Macielag , Mark Wall , Michael P. Winters , Yue-Mei Zhang , Zhihua Sui
IPC分类号： C07D213/55 , C07C255/46 , C07D307/40 , C07C57/46 , C07D277/24 , C07C57/38
摘要： The present invention is directed to cycloalkenyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the GPR120 and/or GPR40 receptors. More particularly, the compounds of the present invention are agonists of GPR120 and/or GPR40, useful in the treatment of, for example, obesity, Type II Diabetes Mellitus, dyslipidemia, etc.
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2.发明授权Benzimidazole derivatives useful as selective androgen receptor modulators (SARMS) 有权可用作选择性雄激素受体调节剂（SARMS）的苯并咪唑衍生物公开(公告)号：US08586616B2
公开(公告)日：2013-11-19
申请号：US12970554
申请日：2010-12-16
申请人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
发明人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
IPC分类号： A61K31/4184 , C07D235/12
CPC分类号： C07D403/06 , C07D235/10 , C07D235/12 , C07D235/16 , C07D401/06 , C07D403/10 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/10
摘要： The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有它们的药物组合物及其在治疗由雄激素受体调节的病症和状况中的用途。
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公开(公告)号：US08269015B2
公开(公告)日：2012-09-18
申请号：US12760832
申请日：2010-04-15
申请人： Xuqing Zhang , Heather Rae Hufnagel , Chaozhong Cai , James C. Lanter , Thomas P. Markotan , Zhihua Sui
发明人： Xuqing Zhang , Heather Rae Hufnagel , Chaozhong Cai , James C. Lanter , Thomas P. Markotan , Zhihua Sui
IPC分类号： C07D401/00 , A01N43/00
CPC分类号： C07D401/08 , C07D403/08 , C07D413/08 , C07D417/08 , C07D471/04
摘要： The present invention comprises compounds of Formula (I). wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
摘要翻译： 本发明包括式（I）的化合物。 其中：X，R1，R2，R3和R4如说明书中所定义。 本发明还包括预防，治疗或改善综合征，病症或疾病的方法，其中所述综合征，病症或疾病是II型糖尿病，肥胖症和哮喘。 本发明还包括通过施用治疗有效量的至少一种式（I）化合物来抑制哺乳动物CCR2活性的方法。
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4.发明申请NOVEL INDOLE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) 有权作为选择性受体调节剂（SARMS）的新型吲哚衍生物公开(公告)号：US20090216023A1
公开(公告)日：2009-08-27
申请号：US12188586
申请日：2008-08-08
申请人： James C. Lanter , Zhihua Sui , James J. Fiordeliso , Weiqin Jiang , Xuqing Zhang
发明人： James C. Lanter , Zhihua Sui , James J. Fiordeliso , Weiqin Jiang , Xuqing Zhang
IPC分类号： C07D487/04 , C07D401/02 , C07D209/12
CPC分类号： C07D209/12 , A61K31/407 , A61K31/4985 , A61K31/5025 , A61K31/519 , C07D209/08 , C07D209/30 , C07D401/04 , C07D405/04 , C07D409/04 , C07D487/04
摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的吲哚衍生物，含有它们的药物组合物及其用于治疗由雄激素受体调节的病症和状况。
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5.发明授权Benzimidazole derivatives useful as selective androgen receptor modulators (sarms) 有权可用作选择性雄激素受体调节剂（arms arms）的苯并咪唑衍生物公开(公告)号：US07566733B2
公开(公告)日：2009-07-28
申请号：US11235024
申请日：2005-09-26
申请人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
发明人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
IPC分类号： A61K31/4184 , C07D235/10 , C07D235/12
CPC分类号： C07D403/06 , C07D235/10 , C07D235/12 , C07D235/16 , C07D401/06 , C07D403/10 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/10
摘要： The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有它们的药物组合物及其在治疗由雄激素受体调节的病症和状况中的用途。
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6.发明授权Benzimidazole derivatives useful as selective androgen receptor modulators (SARMS) 有权可用作选择性雄激素受体调节剂（SARMS）的苯并咪唑衍生物公开(公告)号：US07348438B2
公开(公告)日：2008-03-25
申请号：US11235581
申请日：2005-09-26
申请人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
发明人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
IPC分类号： C07D235/16
CPC分类号： C07D405/06 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D401/06 , C07D403/10 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/10
摘要： The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有它们的药物组合物及其在治疗由雄激素受体调节的病症和状况中的用途。
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7.发明授权公开(公告)号：US07288553B2
公开(公告)日：2007-10-30
申请号：US11096673
申请日：2005-04-01
申请人： James C. Lanter , Zhihua Sui , James J. Fiordeliso , Weiqin Jiang , Xuqing Zhang
发明人： James C. Lanter , Zhihua Sui , James J. Fiordeliso , Weiqin Jiang , Xuqing Zhang
IPC分类号： C07D209/12 , A61K31/404
CPC分类号： C07D209/12 , C07D405/04
摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的吲哚衍生物，含有它们的药物组合物及其用于治疗由雄激素受体调节的病症和状况。
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8.发明授权Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors 有权用作磷酸二酯酶抑制剂的取代的吡咯并吡喃酮衍生物公开(公告)号：US06818646B2
公开(公告)日：2004-11-16
申请号：US10638901
申请日：2003-08-11
申请人： Zhihua Sui , Mark J. Macielag , Jihua Guan , Weigin Jiang , James C. Lanter
发明人： Zhihua Sui , Mark J. Macielag , Jihua Guan , Weigin Jiang , James C. Lanter
IPC分类号： A61K314965
CPC分类号： C07D471/04
摘要： The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction.
摘要翻译： 本发明涉及式（I）或（II）的新型吡咯并吡喃酮衍生物：含有化合物的药物组合物及其用于治疗性功能障碍的用途。
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9.发明授权Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors 有权用作磷酸二酯酶抑制剂的取代的吡咯并吡喃酮衍生物公开(公告)号：US06635638B2
公开(公告)日：2003-10-21
申请号：US09847749
申请日：2001-05-02
申请人： Zhihua Sui , Mark J. Macielag , Jihua Guan , Weiqin Jiang , James C. Lanter
发明人： Zhihua Sui , Mark J. Macielag , Jihua Guan , Weiqin Jiang , James C. Lanter
IPC分类号： C07D47104
CPC分类号： C07D471/04
摘要： The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction.
摘要翻译： 本发明涉及式（I）或（II）的新型吡咯并吡喃酮衍生物：含有化合物的药物组合物及其用于治疗性功能障碍的用途。
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10.发明授权Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods 有权神经营养性2-氮杂环丁烷羧酸衍生物及相关组合物和方法公开(公告)号：US06544976B1
公开(公告)日：2003-04-08
申请号：US09592531
申请日：2000-06-12
申请人： James C. Lanter , Suying Zhang , Boyu Zhao
发明人： James C. Lanter , Suying Zhang , Boyu Zhao
IPC分类号： A01N4300
CPC分类号： C07D401/12 , C07D205/04 , C07D401/14 , C07D409/06
摘要： This invention provides compounds having the following general structure: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders characterized by neuronal damage.
摘要翻译： 本发明提供具有以下一般结构的化合物：本发明还提供包含其的药物组合物和使用这些组合物治疗和预防以神经元损伤为特征的疾病的方法。
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