-
公开(公告)号：US20090318481A1
公开(公告)日：2009-12-24
申请号：US12549552
申请日：2009-08-28
申请人： Thomas Daniel AICHER , Guillermo S. CORTEZ , Todd Michael GROENDYKE , Albert KHILEVICH , James Allen KNOBELSDORF , Fredrik Pehr MARMSATER , Jeffrey Michael SCHKERYANTZ , Tony Pisal TANG
发明人： Thomas Daniel AICHER , Guillermo S. CORTEZ , Todd Michael GROENDYKE , Albert KHILEVICH , James Allen KNOBELSDORF , Fredrik Pehr MARMSATER , Jeffrey Michael SCHKERYANTZ , Tony Pisal TANG
IPC分类号： A61K31/19 , C07D309/00 , A61K31/695 , A61K31/35 , C07C255/00 , A61K31/24 , C07D401/00 , C07D211/78 , C07D239/02 , C07D333/24 , A61K31/381 , A61K31/425 , C07D277/00 , A61K31/505 , C07D271/06 , A61K31/44 , C07C229/00 , A61K31/275 , C07D257/04 , A61K31/41 , C07C63/04
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
摘要翻译： 本申请涉及式I的取代羟基苯基酮化合物或其药学上可接受的盐，其药物组合物及其在治疗偏头痛中的用途。 本申请还涉及制备式I化合物的方法和其中有用的中间体化合物。
-
公开(公告)号：US07816523B2
公开(公告)日：2010-10-19
申请号：US12549552
申请日：2009-08-28
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： C07D239/32 , C07D213/02
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
-
公开(公告)号：US07678794B2
公开(公告)日：2010-03-16
申请号：US11718742
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： A61K31/50 , C07D209/54
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides a compound of formula (I): pharmaceutical compositions thereof, and methods of using the same, processes for preparing the same, and intermediates thereof.
摘要翻译： 本发明提供式（I）化合物：其药物组合物及其使用方法，其制备方法及其中间体。
-
公开(公告)号：US20080139505A1
公开(公告)日：2008-06-12
申请号：US11718753
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
IPC分类号： A61K31/19 , C07D309/00 , A61K31/695 , A61K31/35 , C07C255/00 , A61K31/24 , C07D401/00 , C07D211/78 , C07D239/02 , C07D333/24 , A61K31/381 , A61K31/425 , C07D277/00 , A61K31/505 , C07D271/06 , A61K31/44 , C07C229/00 , A61K31/275 , A61K31/41 , C07D257/04 , C07C63/04
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides compounds of formula (I): pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof.
摘要翻译： 本发明提供式（I）化合物：其药物组合物及其使用方法，方法或制备方法及其中间体。
-
公开(公告)号：US07858646B2
公开(公告)日：2010-12-28
申请号：US11718446
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Dana Rae Benesh , Maria-Jesus Blanco-Pillado , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsäter , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Dana Rae Benesh , Maria-Jesus Blanco-Pillado , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsäter , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： C07D401/04 , C07D213/79 , A61K31/41 , A61K31/4439
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides compounds of formula (I); pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof.
摘要翻译： 本发明提供式（I）化合物; 其药物组合物及其使用方法，方法或制备方法及其中间体。
-
公开(公告)号：US07803938B2
公开(公告)日：2010-09-28
申请号：US12549571
申请日：2009-08-28
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Micheal Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Micheal Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang
IPC分类号： C07D239/32 , C07D271/113 , C07D291/04
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
摘要翻译： 本申请涉及式I的取代羟基苯基酮化合物或其药学上可接受的盐，其药物组合物及其在治疗偏头痛中的用途。 本申请还涉及制备式I化合物的方法和其中有用的中间体化合物。
-
公开(公告)号：US20090318483A1
公开(公告)日：2009-12-24
申请号：US12549571
申请日：2009-08-28
申请人： Thomas Daniel AICHER , Guillermo S. CORTEZ , Todd Micheal GROENDYKE , Albert KHILEVICH , James Allen KNOBELSDORF , Fredrik Pehr MARMSATER , Jeffrey Michael SCHKERYANTZ , Tony Pisal TANG
发明人： Thomas Daniel AICHER , Guillermo S. CORTEZ , Todd Micheal GROENDYKE , Albert KHILEVICH , James Allen KNOBELSDORF , Fredrik Pehr MARMSATER , Jeffrey Michael SCHKERYANTZ , Tony Pisal TANG
IPC分类号： A61K31/41 , C07D257/04 , C07D401/04 , C07D239/42 , A61K31/4439 , A61K31/513 , A61P25/06
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
-
公开(公告)号：US06703425B2
公开(公告)日：2004-03-09
申请号：US10276738
申请日：2002-11-15
申请人： James Allen Knobelsdorf , Timothy Alan Shepherd , Eric George Tromiczak , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
发明人： James Allen Knobelsdorf , Timothy Alan Shepherd , Eric George Tromiczak , Hamideh Zarrinmayeh , Dennis Michael Zimmerman
IPC分类号： A61K3118
CPC分类号： C07D213/42 , C07C311/05 , C07C2601/14 , C07D235/14 , C07D333/20
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders
摘要翻译： 本发明涉及可用于治疗与谷氨酸功能减退有关的病症的式（I）化合物或其药学上可接受的盐，例如精神和神经障碍
-
公开(公告)号：US07598423B2
公开(公告)日：2009-10-06
申请号：US11718753
申请日：2005-11-15
申请人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
发明人： Thomas Daniel Aicher , Guillermo S. Cortez , Todd Michael Groendyke , Albert Khilevich , James Allen Knobelsdorf , Fredrik Pehr Marmsater , Jeffrey Michael Schkeryantz , Tony Pisal Tang , Nicholas Andrew Magnus
IPC分类号： C07D239/26 , C07D239/28 , C07D241/10 , C07D401/10 , C07D213/02 , C07D291/04 , C07D271/06 , C07D277/20 , C07D417/10 , C07D333/06 , C07D319/06 , C07C49/76
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.
摘要翻译： 本申请涉及式I的取代羟基苯基酮化合物或其药学上可接受的盐，其药物组合物及其在治疗偏头痛中的用途。 本申请还涉及制备式I化合物的方法和其中有用的中间体化合物。
-
公开(公告)号：US07528160B2
公开(公告)日：2009-05-05
申请号：US10541502
申请日：2003-12-31
申请人： Scott Eugene Conner , James Allen Knobelsdorf , Nathan Bryan Mantlo , Daniel Ray Mayhugh , Xiaodong Wang , Guoxin Zhu , Jeffrey Michael Schkeryantz
发明人： Scott Eugene Conner , James Allen Knobelsdorf , Nathan Bryan Mantlo , Daniel Ray Mayhugh , Xiaodong Wang , Guoxin Zhu , Jeffrey Michael Schkeryantz
IPC分类号： A61K31/427 , C07D277/24
CPC分类号： C07D263/57 , C07D209/10 , C07D235/18 , C07D277/60 , C07D277/66 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention is directed to a method of treatment by modulating a peroxisome proliferator activated receptor by employing a compound of Structural Formula (I). The variables in I are defined herein. Also included are compounds, methods of making compounds, and pharmaceutical compositions. The compounds of the present invention are believed to be effective in treating and preventing Syndrome X, Type H diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, atherosclerosis, and other disorders related to Syndrome X and cardiovascular diseases.
摘要翻译： 本发明涉及通过使用结构式（I）的化合物调节过氧化物酶体增殖物激活受体的治疗方法。 I中的变量在此定义。 还包括化合物，制备化合物的方法和药物组合物。 认为本发明的化合物可有效治疗和预防X综合征，H型糖尿病，高血糖症，高脂血症，肥胖症，凝血病，高血压，动脉粥样硬化以及与X综合征和心血管疾病相关的其他疾病。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.027 秒)
