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公开(公告)号：US20150080324A1
公开(公告)日：2015-03-19
申请号：US14553221
申请日：2014-11-25
发明人： Gavin David Heffernan , David Penman Jacobus , Guy Alan Schiehser , Hong-Ming Shieh , Wenyi Zhao
IPC分类号： C07D213/65 , A61K45/06 , A61K31/4418
CPC分类号： C07D213/65 , A61K31/135 , A61K31/137 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/44 , A61K31/4418 , A61K31/4453 , A61K45/06 , C07C215/50 , C07C217/54 , C07C217/58 , C07C317/32 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D213/26 , C07D213/38 , C07D213/64 , C07D295/088 , C07D307/81 , C07D317/58 , Y02A50/411 , A61K2300/00
摘要： The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
摘要翻译： 本发明涉及抗疟疾化合物及其抗疟原虫原生动物的用途，包括耐药性Plasmodia菌株。 本发明还涉及含有这些化合物的组合物和制备该化合物的方法。
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公开(公告)号：US20180086710A1
公开(公告)日：2018-03-29
申请号：US15695043
申请日：2017-09-05
发明人： Guy Alan Schiehser , Rajendra Shah , Wenyi Zhao
IPC分类号： C07D213/73 , C07D401/04 , G01N30/74
CPC分类号： C07D213/73 , C07D401/04 , G01N30/74 , G01N2030/027 , G01N2030/884 , G01N2030/8872
摘要： The present invention relates to methods of determining the purity of a sample of 3,4-diaminopyridine comprising determining the presence, absence, or amount of a dimer of 3,4-diaminopyridine or a dimer of 3,4-diaminopyridine in the form of a salt, solvate or complex or a combination thereof. The invention also relates to methods of detecting and quantitating degradation in a sample of 3,4-diaminopyridine. Dimers of 3,4-diaminopyridine and methods of making and isolating the same are also provided.
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公开(公告)号：US09409893B2
公开(公告)日：2016-08-09
申请号：US14074819
申请日：2013-11-08
发明人： Gavin David Heffernan , David Penman Jacobus , Kurt William Saionz , Guy Alan Schiehser , Hong-Ming Shieh , Wenyi Zhao
IPC分类号： A61K31/535 , A61K38/00 , A61P33/00 , A01N37/18 , C07D413/04 , A61K31/343 , A61K31/381 , A61K31/415 , A61K31/4418 , A61K31/4439 , A61K31/47 , A61K31/496 , A61K31/505 , A61K31/536 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/64 , C07D213/73 , C07D215/14 , C07D231/12 , C07D239/26 , C07D307/81 , C07D333/28 , C07D333/58 , C07D213/84 , C07D217/16 , C07D401/10 , C07D241/12 , C07D213/36 , C07D213/61 , C07D213/65 , C07D307/80
CPC分类号： C07D413/04 , A61K31/343 , A61K31/381 , A61K31/415 , A61K31/4418 , A61K31/4439 , A61K31/47 , A61K31/496 , A61K31/505 , A61K31/536 , A61K31/5377 , A61K45/06 , C07D213/36 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/84 , C07D215/14 , C07D217/16 , C07D231/12 , C07D239/26 , C07D241/12 , C07D307/80 , C07D307/81 , C07D333/28 , C07D333/58 , C07D401/10 , Y02A50/411
摘要： The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
摘要翻译： 本发明涉及抗疟疾化合物及其抗疟原虫原生动物的用途，包括耐药性Plasmodia菌株。 本发明还涉及含有这些化合物的组合物和制备该化合物的方法。
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公开(公告)号：US09296696B2
公开(公告)日：2016-03-29
申请号：US14553221
申请日：2014-11-25
发明人： Gavin David Heffernan , David Penman Jacobus , Guy Alan Schiehser , Hong-Ming Shieh , Wenyi Zhao
IPC分类号： A61K31/44 , C07D213/72 , C07D213/65 , A61K31/343 , A61K45/06 , C07C215/50 , C07D213/38 , C07D213/64 , C07D307/81 , C07D317/58 , C07C317/32 , C07D213/26 , C07C217/54 , C07C217/58 , C07D295/088 , A61K31/137 , A61K31/36 , A61K31/135 , A61K31/357 , A61K31/4453 , A61K31/4418
CPC分类号： C07D213/65 , A61K31/135 , A61K31/137 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/44 , A61K31/4418 , A61K31/4453 , A61K45/06 , C07C215/50 , C07C217/54 , C07C217/58 , C07C317/32 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D213/26 , C07D213/38 , C07D213/64 , C07D295/088 , C07D307/81 , C07D317/58 , Y02A50/411 , A61K2300/00
摘要： The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
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公开(公告)号：US20140135320A1
公开(公告)日：2014-05-15
申请号：US14074819
申请日：2013-11-08
发明人： Gavin David Heffernan , David Penman Jacobus , Kurt William Saionz , Guy Alan Schiehser , Hong-Ming Shieh , Wenyi Zhao
IPC分类号： C07D413/04 , A61K31/5377 , A61K31/496 , A61K31/505 , A61K31/47 , A61K31/4439 , A61K31/4418 , A61K31/415 , A61K31/381 , A61K31/343 , C07D239/26 , C07D215/14 , C07D213/64 , C07D213/73 , C07D213/38 , C07D231/12 , C07D333/28 , C07D307/81 , A61K45/06 , A61K31/536
CPC分类号： C07D413/04 , A61K31/343 , A61K31/381 , A61K31/415 , A61K31/4418 , A61K31/4439 , A61K31/47 , A61K31/496 , A61K31/505 , A61K31/536 , A61K31/5377 , A61K45/06 , C07D213/36 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/73 , C07D213/84 , C07D215/14 , C07D217/16 , C07D231/12 , C07D239/26 , C07D241/12 , C07D307/80 , C07D307/81 , C07D333/28 , C07D333/58 , C07D401/10 , Y02A50/411
摘要： The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
摘要翻译： 本发明涉及抗疟疾化合物及其抗疟原虫原生动物的用途，包括耐药性Plasmodia菌株。 本发明还涉及含有这些化合物的组合物和制备该化合物的方法。
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公开(公告)号：US08962657B2
公开(公告)日：2015-02-24
申请号：US14074830
申请日：2013-11-08
发明人： Gavin David Heffernan , David Penman Jacobus , Guy Alan Schiehser , Hong-Ming Shieh , Wenyi Zhao
IPC分类号： C07C211/00 , A61K31/445 , C07D307/81 , A61K31/135 , A61K31/343 , A61K31/357 , A61K31/44 , A61K31/4453 , A61K45/06 , C07C215/50 , C07D213/38 , C07D213/64 , C07D317/58 , C07C317/32 , C07D213/26 , C07D213/65 , C07C217/54 , C07C217/58 , C07D295/088
CPC分类号： C07D213/65 , A61K31/135 , A61K31/137 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/44 , A61K31/4418 , A61K31/4453 , A61K45/06 , C07C215/50 , C07C217/54 , C07C217/58 , C07C317/32 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D213/26 , C07D213/38 , C07D213/64 , C07D295/088 , C07D307/81 , C07D317/58 , Y02A50/411 , A61K2300/00
摘要： The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
摘要翻译： 本发明涉及抗疟疾化合物及其抗疟原虫原生动物的用途，包括耐药性Plasmodia菌株。 本发明还涉及含有这些化合物的组合物和制备该化合物的方法。
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公开(公告)号：US09783497B1
公开(公告)日：2017-10-10
申请号：US15179060
申请日：2016-06-10
发明人： Guy Alan Schiehser , Rajendra Shah , Wenyi Zhao
IPC分类号： G01N24/00 , C07D213/73 , G01N30/74 , G01N30/02
CPC分类号： C07D213/73 , C07D401/04 , G01N30/74 , G01N2030/027 , G01N2030/884 , G01N2030/8872
摘要： The present invention relates to methods of determining the purity of a sample of 3,4-diaminopyridine comprising determining the presence, absence, or amount of a dimer of 3,4-diaminopyridine or a dimer of 3,4-diaminopyridine in the form of a salt, solvate or complex or a combination thereof. The invention also relates to methods of detecting and quantitating degradation in a sample of 3,4-diaminopyridine. Dimers of 3,4-diaminopyridine and methods of making and isolating the same are also provided.
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公开(公告)号：US20140135360A1
公开(公告)日：2014-05-15
申请号：US14074830
申请日：2013-11-08
发明人： Gavin David Heffernan , David Penman Jacobus , Guy Alan Schiehser , Hong-Ming Shieh , Wenyi Zhao
IPC分类号： C07D317/46 , A61K31/44 , A61K31/357 , A61K31/343 , A61K45/06 , C07D211/22 , C07D213/64 , C07D213/38 , C07D307/81 , C07C215/50 , A61K31/4453 , A61K31/135
CPC分类号： C07D213/65 , A61K31/135 , A61K31/137 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/44 , A61K31/4418 , A61K31/4453 , A61K45/06 , C07C215/50 , C07C217/54 , C07C217/58 , C07C317/32 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D213/26 , C07D213/38 , C07D213/64 , C07D295/088 , C07D307/81 , C07D317/58 , Y02A50/411 , A61K2300/00
摘要： The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
摘要翻译： 本发明涉及抗疟疾化合物及其抗疟原虫原生动物的用途，包括耐药性Plasmodia菌株。 本发明还涉及含有这些化合物的组合物和制备该化合物的方法。
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