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1.发明授权Method of controlling quantum dot photoluminescence and other intrinsic properties through biological specificity 失效通过生物学特异性控制量子点光致发光和其他固有性质的方法公开(公告)号：US07858386B2
公开(公告)日：2010-12-28
申请号：US11683226
申请日：2007-03-07
申请人： Igor L Medintz , Hedi M Mattoussi , Moungi G Bawendi , J Matthew Mauro , George P Anderson , Thomas Pons
发明人： Igor L Medintz , Hedi M Mattoussi , Moungi G Bawendi , J Matthew Mauro , George P Anderson , Thomas Pons
IPC分类号： G01N21/64 , G01N33/551 , C12Q1/37
CPC分类号： G01N33/588 , B82Y15/00 , C12Q1/6825 , G01N33/542 , Y10T436/143333
摘要： A method of controllably changing an intrinsic property of a quantum dot by using a biological entity, either attached or in close proximity to the quantum dot, and changing the state of biological entity with a controllable mechanism. The change in state of the biological entity controllably changes the intrinsic property of the quantum dot. The photoluminescence emission of quantum dots can be controlled by the present method. The methods disclosed include controlling the magnitude of QD photoluminescence as well as turning the photoluminescence on/off. The methods disclosed include using the same biological control architecture to control other intrinsic QD properties such as charge state, magnetic or other property.
摘要翻译： 通过使用附着或非常接近量子点的生物实体可控地改变量子点的固有特性的方法，并以可控机制改变生物实体的状态。 生物体的状态变化可以控制地改变量子点的固有特性。 量子点的光致发光可通过本方法进行控制。 所公开的方法包括控制QD光致发光的大小以及打开/关闭光致发光。 所公开的方法包括使用相同的生物学控制结构来控制其它固有QD特性，例如电荷状态，磁性或其他性质。
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公开(公告)号：US20100308275A1
公开(公告)日：2010-12-09
申请号：US12318028
申请日：2008-12-19
IPC分类号： C09K11/02
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译： 离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。
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公开(公告)号：US07470379B2
公开(公告)日：2008-12-30
申请号：US11080946
申请日：2005-03-16
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译： 离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。
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公开(公告)号：US06921496B2
公开(公告)日：2005-07-26
申请号：US09811824
申请日：2001-03-20
IPC分类号： G01N33/566 , G01N33/53 , G01N33/551 , G01N33/58 , C09K11/54 , C12P21/00
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译： 离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。
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5.发明授权Passivation of nerve agents by surface modified enzymes stabilized by non-covalent immobilization on robust, stable particles 失效通过表面修饰的酶将神经毒剂钝化，通过非共价固定化稳定稳定的稳定颗粒公开(公告)号：US06869784B2
公开(公告)日：2005-03-22
申请号：US09725309
申请日：2000-11-29
摘要： Enzymes are modified by incorporating anchor sites for linking the enzymes to a target surface without destroying the catalytic activity of the enzymes. A stable carrier to accommodate and bind the selected enzyme is constructed, and the enzyme is non-covalently linked to the carrier, generally through metal salts of iminodiacetate.
摘要翻译： 通过引入用于将酶连接到靶表面的锚定位点而不破坏酶的催化活性来修饰酶。 构建适应和结合选定酶的稳定载体，通常通过亚氨基二乙酸盐的金属盐将酶非共价连接到载体上。
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公开(公告)号：US06713272B2
公开(公告)日：2004-03-30
申请号：US09955023
申请日：2001-09-19
IPC分类号： G01N3353
CPC分类号： G01N33/54393
摘要： A recombinant protein that is a fusion protein containing a protein binding domain and a domain that is post-translationally modified to become lipid-tagged. This molecule has both a domain with highly specific binding capabilities and a domain which is very hydrophobic in nature. This type of molecule can be used to coat hydrophobic surfaces such as polystyrene easily and effectively for use in solid phase binding assays.
摘要翻译： 重组蛋白，其是含有蛋白质结合结构域和翻译后修饰以变成脂质标记的结构域的融合蛋白。 该分子具有具有高度特异性结合能力的结构域和本质上非常疏水的结构域。 这种类型的分子可用于容易且有效地涂覆疏水性表面如聚苯乙烯用于固相结合测定。
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公开(公告)号：US20110319601A1
公开(公告)日：2011-12-29
申请号：US13229177
申请日：2011-09-09
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译： 离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。
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公开(公告)号：US08034259B2
公开(公告)日：2011-10-11
申请号：US12318028
申请日：2008-12-19
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译： 离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。
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9.发明申请Passivation of nerve agents by surface modified enzymes stabilized by non-covalent immobilization on robust, stable particles 审中-公开通过表面修饰的酶将神经毒剂钝化，通过非共价固定化稳定稳定的稳定颗粒公开(公告)号：US20090325261A1
公开(公告)日：2009-12-31
申请号：US11001600
申请日：2004-11-29
IPC分类号： C12N11/14
摘要： Enzymes are modified by incorporating anchor sites for linking the enzymes to a target surface without destroying the catalytic activity of the enzymes. A stable carrier to accommodate and bind the selected enzyme is constructed, and the enzyme is non-covalently liked to the carrier, generally through metal salts of iminodiacetate
摘要翻译： 通过引入用于将酶连接到靶表面的锚定位点而不破坏酶的催化活性来修饰酶。 构建适应和结合选定酶的稳定载体，并且该酶通常通过亚氨基二乙酸盐的金属盐非共价地与载体一致
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公开(公告)号：US08192646B2
公开(公告)日：2012-06-05
申请号：US13229177
申请日：2011-09-09
CPC分类号： B82Y15/00 , G01N33/551 , G01N33/588
摘要： The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
摘要翻译： 离子共轭物包括与大分子静电相关的无机颗粒，其可以与预定的化学物质或生物靶相互作用。
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