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公开(公告)号：US09915653B2
公开(公告)日：2018-03-13
申请号：US14241578
申请日：2012-08-31
IPC分类号： G01N33/555 , G01N33/554 , G01N33/68 , G01N33/92 , G01N33/571
CPC分类号： G01N33/555 , G01N33/554 , G01N33/571 , G01N33/6815 , G01N33/92 , G01N2333/005 , G01N2333/20
摘要： Method of localizing a sulfhydryl (—SH) group containing biomolecule to the surface of a cell membrane by mixing in a volatile reaction buffer a molar excess of the sulfhydryl (—SH) group containing biomolecule with a lipid conjugated maleimide of the structure F-S-L as defined in the specification to provide a reaction mix, incubating the reaction mix for a time and at a temperature sufficient to allow all the lipid conjugated maleimide to have reacted with the sulfhydryl (—SH) group, and freeze-drying the reaction mix to remove the volatile reaction buffer and provide a reaction product. An aqueous solution of the reaction product is contacted with the cell membrane.
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公开(公告)号：US20170231228A1
公开(公告)日：2017-08-17
申请号：US15585296
申请日：2017-05-03
IPC分类号： A01N57/12
CPC分类号： A01N57/12 , A61L15/46 , A61L27/042 , A61L27/50 , A61L27/54 , A61L31/022 , A61L31/14 , A61L31/16 , A61L2300/22 , A61L2300/404 , A01N25/04
摘要： An antimicrobial surface treatment method comprising the step of contacting a stainless-steel surface with an aqueous dispersion of at least one functional-lipid construct where the lipid moiety is a phosphatidylethanolamine and the functional moiety confers the antimicrobial activity.
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公开(公告)号：US20120021430A1
公开(公告)日：2012-01-26
申请号：US12734072
申请日：2008-10-13
申请人： Nicolai Vladimirovich Bovin , Stephen Micheal Henry , Igor Leonidovich Rodionov , Cristina-Simona Weinberg , Alexander Borisovich Tuzikov
发明人： Nicolai Vladimirovich Bovin , Stephen Micheal Henry , Igor Leonidovich Rodionov , Cristina-Simona Weinberg , Alexander Borisovich Tuzikov
CPC分类号： C07K7/02 , A61K47/544 , A61K47/65 , C07F9/106 , C07F9/572 , C07F9/6561 , C07K5/02 , C07K7/06 , C07K7/08 , G01N33/80
摘要： The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
摘要翻译： 本发明涉及用于实现在细胞和多细胞结构表面表达的功能部分的定性和定量变化的方法，以及用于这些方法的功能性脂质构建体。 特别地，本发明涉及功能性脂质构建体及其在诊断和治疗应用中的应用，包括血清诊断，其中功能部分是碳水化合物，肽，化学反应性基团，共轭体或荧光团。
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公开(公告)号：US09821080B2
公开(公告)日：2017-11-21
申请号：US13984050
申请日：2012-02-09
申请人： Nikolai Vladimirovich Bovin , Stephen Henry , Elena Yurievna Korchagina , Igor Leonidovich Rodionov , Alexander Borisovich Tuzikov
发明人： Nikolai Vladimirovich Bovin , Stephen Henry , Elena Yurievna Korchagina , Igor Leonidovich Rodionov , Alexander Borisovich Tuzikov
CPC分类号： C07K7/08 , A61K51/0408 , A61K51/08 , A61K51/088 , C07F9/10
摘要： Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.
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公开(公告)号：US20170320914A1
公开(公告)日：2017-11-09
申请号：US15528732
申请日：2015-11-23
申请人： Nicolai Vladimirovich BOVIN , Stephen Micheal HENRY , Elena KORCHAGINA , Igor Leonidovich RODIONOV , Alexander Borisovich TUZIKOV
发明人： Nicolai Vladimirovich BOVIN , Stephen Micheal HENRY , Elena KORCHAGINA , Igor Leonidovich RODIONOV , Alexander Borisovich TUZIKOV
IPC分类号： C07K9/00
CPC分类号： C07K9/00 , A61K31/685 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K38/00 , A61K47/555 , C07K7/06 , C07K7/08 , C07K14/001
摘要： Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.
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公开(公告)号：US08669084B2
公开(公告)日：2014-03-11
申请号：US12734072
申请日：2008-10-13
申请人： Nicolai Vladimirovich Bovin , Stephen Micheal Henry , Igor Leonidovich Rodionov , Cristina-Simona Weinberg , Alexander Borisovich Tuzikov
发明人： Nicolai Vladimirovich Bovin , Stephen Micheal Henry , Igor Leonidovich Rodionov , Cristina-Simona Weinberg , Alexander Borisovich Tuzikov
IPC分类号： G01N33/80 , A61K31/7032
CPC分类号： C07K7/02 , A61K47/544 , A61K47/65 , C07F9/106 , C07F9/572 , C07F9/6561 , C07K5/02 , C07K7/06 , C07K7/08 , G01N33/80
摘要： The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
摘要翻译： 本发明涉及用于实现在细胞和多细胞结构表面表达的功能部分的定性和定量变化的方法，以及用于这些方法的功能性脂质构建体。 特别地，本发明涉及功能性脂质构建体及其在诊断和治疗应用中的应用，包括血清诊断，其中功能部分是碳水化合物，肽，化学反应性基团，共轭体或荧光团。
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公开(公告)号：US20200048309A1
公开(公告)日：2020-02-13
申请号：US16665016
申请日：2019-10-28
申请人： Nicolai Vladimirovich BOVIN , Stephen Micheal HENRY , Elena KORCHAGINA , Igor Leonidovich RODIONOV , Alexander Borisovich TUZIKOV
发明人： Nicolai Vladimirovich BOVIN , Stephen Micheal HENRY , Elena KORCHAGINA , Igor Leonidovich RODIONOV , Alexander Borisovich TUZIKOV
IPC分类号： C07K9/00 , A61K31/685 , A61K31/7004 , A61K31/702 , A61K31/7016 , C07K7/06 , A61K47/54 , C07K14/00 , C07K7/08
摘要： Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.
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公开(公告)号：US10457706B2
公开(公告)日：2019-10-29
申请号：US15528732
申请日：2015-11-23
申请人： Stephen Micheal Henry , Elena Korchagina , Igor Leonidovich Rodionov , Alexander Borisovich Tuzikov
发明人： Nicolai Vladimirovich Bovin , Stephen Micheal Henry , Elena Korchagina , Igor Leonidovich Rodionov , Alexander Borisovich Tuzikov
IPC分类号： A61K31/702 , C07K9/00 , A61K31/7004 , A61K31/685 , A61K31/7016 , C07K7/06 , C07K7/08 , C07K14/00 , A61K47/54 , A61K38/00
摘要： Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.
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9.发明申请公开(公告)号：US20180259513A1
公开(公告)日：2018-09-13
申请号：US15882714
申请日：2018-01-29
IPC分类号： G01N33/555 , G01N33/92 , G01N33/68 , G01N33/554 , G01N33/571
摘要： A facile laboratory-based method and kit for use in accordance with the method is disclosed. The method allows for the localisation of biomolecules comprising a conjugatable sulfhydryl group to be localised to the surface of cells, such as red blood cells, as lipid conjugates. The method obviates the need to purify the lipid-conjugated biomolecule before contacting with the cells.
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公开(公告)号：US20140161723A1
公开(公告)日：2014-06-12
申请号：US13984050
申请日：2012-02-09
申请人： Nikolai Vladimirovich Bovin , Stephen Henry , Elena Yurievna Korchagina , Igor Leonidovich Rodionov , Alexander Borisovich Tuzikov
发明人： Nikolai Vladimirovich Bovin , Stephen Henry , Elena Yurievna Korchagina , Igor Leonidovich Rodionov , Alexander Borisovich Tuzikov
IPC分类号： A61K51/08
CPC分类号： C07K7/08 , A61K51/0408 , A61K51/08 , A61K51/088 , C07F9/10
摘要： Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.
摘要翻译： 公开了结构F-S-L的功能 - 脂质构建体，其中F包含酪氨酸或组氨酸残基，S是共价连接F与L并且L是脂质的间隔基。 功能性残基可以被碘化并且用于用1251放射性标记生物实体，并且碘化构建体用于监测生物体在体内分布的非侵入性方法。
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