公开(公告)号：US10688055B2

公开(公告)日：2020-06-23

申请号：US14274384

申请日：2014-05-09

申请人： INSPIRION DELIVERY SCIENCES LLC

发明人： Manish S. Shah ,  Ray J. DiFalco

IPC分类号： A61K9/24 ,  A61K9/28 ,  A61K9/32 ,  A61K9/20 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458 ,  A61K9/48 ,  A61K31/485 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US10729685B2

公开(公告)日：2020-08-04

申请号：US14486433

申请日：2014-09-15

申请人： Inspirion Delivery Sciences, LLC

发明人： Manish S. Shah ,  Ray J. DiFalco ,  Stefan Aigner

IPC分类号： A61K9/20 ,  A61K9/26 ,  A61K31/44 ,  A61K31/485 ,  A61K9/14 ,  A61K9/00 ,  A61K31/4468

摘要： Orally administrable pharmaceutical compositions and methods of administration are provided. The pharmaceutical compositions provide abuse deterrent properties.

公开(公告)号：US20190209480A1

公开(公告)日：2019-07-11

申请号：US16360865

申请日：2019-03-21

申请人： INSPIRION DELIVERY SCIENCES LLC

发明人： Manish S. SHAH ,  Ray J. DIFALCO

IPC分类号： A61K9/20 ,  A61K31/4458 ,  A61K31/437 ,  A61K31/138 ,  A61K9/48 ,  A61K9/16 ,  A61K31/485 ,  A61K9/28 ,  A61K9/24 ,  A61K9/50 ,  A61K47/38 ,  A61K47/32 ,  A61K47/34

CPC分类号： A61K9/2086 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/1676 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2081 ,  A61K9/209 ,  A61K9/28 ,  A61K9/2846 ,  A61K9/2886 ,  A61K9/4808 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/4891 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5042 ,  A61K9/5047 ,  A61K9/5078 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458 ,  A61K31/485 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  Y10T156/10

摘要： An oral pharmaceutical composition comprising a drug and one or more pharmaceutically acceptable excipients in a monolithic dosage form, wherein the dosage form is configured such that when the dosage form is divided into more than one piece and at least one of the pieces is administered to a subject the Cmax, AUC, and/or rate of drug released after administration is substantially the same or lower and the Tmax is higher than the Cmax, AUC, rate of drug released, and/or Tmax after administration of: (1) a comparable composition in intact dosage form of equal drug dosage of the administered at least one piece; (2) a bioequiva lent drug composition in an intact dosage form of equal drug dosage to the administered at least one piece; and (3) a divided piece of a bioequivalent drug composition, wherein the divided piece comprises a drug dosage equal to the dosage of the administered piece of the oral composition. Methods of making the same and methods of using the same are also provided.