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    Process for fermenting co-containing gaseous substrates
    1.
    发明授权
    Process for fermenting co-containing gaseous substrates 有权

    公开(公告)号：US10100337B2

    公开(公告)日：2018-10-16

    申请号：US14176094

    申请日：2014-02-09

    Applicant: INEOS BIO SA

    Inventor： Peter Simpson Bell ,  Song Liu

    IPC: C12P7/06 ,  C12P3/00

    Abstract: A process provides high ethanol productivity levels during fermentation of a CO-containing substrate. The process controls CO-substrate feed rates and cell density to avoid culture upset and CO inhibition. The process includes fermenting a CO-containing gaseous substrate to obtain a target cell density and a target CO feed rate, and then periodically reducing and increasing the CO feed rate.

    Process to avoid inhibition of acetogens by CO
    3.
    发明授权
    Process to avoid inhibition of acetogens by CO 有权
    CO避免醋酸菌抑制的过程

    公开(公告)号：US08980575B2

    公开(公告)日：2015-03-17

    申请号：US14018487

    申请日：2013-09-05

    Applicant: Ineos Bio SA

    Inventor： Ryan Senaratne

    IPC: C12Q1/02 ,  B01D51/00

    CPC classification number: C12Q1/04 ,  C12P7/065 ,  C12P7/08 ,  C12Q3/00 ,  G01N21/31 ,  G01N33/84 ,  Y02E50/17

    Abstract: A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a calculated value of about 0.12 mM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a calculated CO concentration in any subsequent fermentation zone of about 0.12 mM or less.

    Abstract translation: 提供了一种用于发酵含CO气体底物的方法。 该方法通过控制CO浓度和最小化发酵过程中高浓度或低CO浓度的影响，有效减少滞后时间并保持培养状态。 该方法包括向第一发酵区提供合成气，发酵合成气，以及确定第一发酵区中发酵培养基中的CO浓度。 如果第一发酵区的发酵培养基中的CO浓度具有约0.12mM或更大的计算值，则将提供给第一发酵区的合成气的至少一部分提供给一个或多个后续的发酵区， 对于在约0.12mM或更少的任何后续发酵区域中提供计算的CO浓度是有效的。

    Process to control CO concentrations in fermentations
    4.
    发明授权
    Process to control CO concentrations in fermentations 有权
    控制发酵中CO浓度的过程

    公开(公告)号：US08975013B2

    公开(公告)日：2015-03-10

    申请号：US14018608

    申请日：2013-09-05

    Applicant: Ineos Bio SA

    Inventor： David Scott Snyder

    IPC: C12Q3/00 ,  G01N33/72 ,  C12P7/06 ,  C12P7/08 ,  G01N21/31 ,  G01N33/84

    CPC classification number: C12Q1/04 ,  C12P7/065 ,  C12P7/08 ,  C12Q3/00 ,  G01N21/31 ,  G01N33/84 ,  Y02E50/17

    Abstract: A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.

    Abstract translation: 用于控制生物反应器中CO浓度的方法提供了发酵培养基中溶解的CO的直接和实时测量。 用于控制生物反应器中CO浓度的方法包括将等分试样的发酵培养基与至少一种CO结合配体和至少一种微生物灭活剂接触。

    CONTROL OF CONDUCTIVITY IN ANAEROBIC FERMENTATION
    5.
    发明申请
    CONTROL OF CONDUCTIVITY IN ANAEROBIC FERMENTATION 有权
    厌氧发酵中电导率的控制

    公开(公告)号：US20140363866A1

    公开(公告)日：2014-12-11

    申请号：US14293089

    申请日：2014-06-02

    Applicant: INEOS BIO SA

    Inventor： Ryan H. Senaratne ,  Peter Simpson Bell ,  Song Liu ,  Syrona R. Scott

    IPC: C12P7/06

    CPC classification number: C12P7/065 ,  C12M41/00 ,  C12N1/20 ,  Y02E50/17

    Abstract: Process are provided which are effective for controlling medium conductivity during fermentation of a CO-containing gaseous substrate while providing an STY of about 10 g ethanol/(L·day) or more. The process includes balancing medium conductivity, specific carbon uptake or cell density levels.

    Abstract translation: 提供了在含CO气体底物的发酵期间有效控制中等电导率的方法，同时提供约10g乙醇/（L·天）或更高的STY。 该过程包括平衡介质电导率，比碳吸收或细胞密度水平。

    Process for the production of ethanol and butanol
    6.
    发明授权
    Process for the production of ethanol and butanol 有权
    生产乙醇和丁醇的方法

    公开(公告)号：US08802406B2

    公开(公告)日：2014-08-12

    申请号：US14051264

    申请日：2013-10-10

    Applicant: INEOS Bio SA

    Inventor： Peter Simpson Bell ,  Stephen John Benstead ,  Neil Turnbull

    IPC: C12P7/06

    CPC classification number: C12P7/14 ,  C12P7/065 ,  C12P7/08 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17

    Abstract: The present invention relates to a process for the production of ethanol and butanol from biomass, and in particular to a process for the production of ethanol and butanol using two separate fermentation step subjecting the biomass feedstock to anaerobic fermentation at a pH below 6.0 and at a temperature in the range 20 to 700° C. and so as to convert the biomass to a product predominantly comprising acetic acid and butyric acid with at least a 2:1 ratio by weight of acetic acid to butyric acid, c) treating the product of stream of step (b) to separate a solution comprising the acetic acid and butyric acid by: (i) separating a solution comprising the acetic acid and butyric acid from any residual solids and (ii) separating bacteria and/or pasteurizing or sterilizing the solution from the first fermentation step, and d) in a second fermentation step fermenting the solution comprising the acetic acid and butyric acid from the step (c) to form ethanol and butanol.

    Abstract translation: 本发明涉及一种从生物质生产乙醇和丁醇的方法，特别涉及一种使用两个分开的发酵步骤生产乙醇和丁醇的方法，该步骤使得生物质原料在pH低于6.0时进行厌氧发酵， 温度在20至700℃的范围内，并且将生物质转化成主要包含乙酸和丁酸的产物，其中乙酸与丁酸的重量比至少为2:1，c）将产物 步骤（b）的流，以通过以下步骤分离包含乙酸和丁酸的溶液：（i）从任何残留固体中分离包含乙酸和丁酸的溶液，和（ii）分离细菌和/或巴氏杀菌或消毒溶液 以及d）在第二发酵步骤中，从步骤（c）将包含乙酸和丁酸的溶液发酵以形成乙醇和丁醇。

    PROCESS TO AVOID INHIBITION OF ACETOGENS BY CO
    7.
    发明申请
    PROCESS TO AVOID INHIBITION OF ACETOGENS BY CO 有权
    防止乙酰胆碱酯酶抑制的方法

    公开(公告)号：US20140080169A1

    公开(公告)日：2014-03-20

    申请号：US14018487

    申请日：2013-09-05

    Applicant: INEOS BIO SA

    Inventor： Ryan Senaratne

    IPC: C12P7/06

    CPC classification number: C12Q1/04 ,  C12P7/065 ,  C12P7/08 ,  C12Q3/00 ,  G01N21/31 ,  G01N33/84 ,  Y02E50/17

    Abstract: A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a calculated value of about 0.12 mM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a calculated CO concentration in any subsequent fermentation zone of about 0.12 mM or less.

    Abstract translation: 提供了一种用于发酵含CO气体底物的方法。 该方法通过控制CO浓度和最小化发酵过程中高浓度或低CO浓度的影响，有效减少滞后时间并保持培养状态。 该方法包括向第一发酵区提供合成气，发酵合成气，以及确定第一发酵区中发酵培养基中的CO浓度。 如果第一发酵区的发酵培养基中的CO浓度具有约0.12mM或更大的计算值，则将提供给第一发酵区的合成气的至少一部分提供给一个或多个后续的发酵区， 对于在约0.12mM或更少的任何后续发酵区域中提供计算的CO浓度是有效的。

    APPARATUS AND METHODS FOR TAR REMOVAL FROM SYNGAS
    9.
    发明申请
    APPARATUS AND METHODS FOR TAR REMOVAL FROM SYNGAS 审中-公开
    从SYNGAS中除去TAR的装置和方法

    公开(公告)号：US20150037229A1

    公开(公告)日：2015-02-05

    申请号：US14518173

    申请日：2014-10-20

    Applicant: INEOS BIO SA

    Inventor： Peter Simpson Bell ,  Ching-Whan Ko ,  Joseph Golab ,  Bernard Descales ,  Julien Eyraud

    IPC: C10K3/00

    Abstract: A process and apparatus are provided for reducing content of tar in a tar containing syngas. The process includes contacting the tar containing syngas with a molecular oxygen containing gas in a first reaction zone to produce a gas mixture. The gas mixture is passed through a heat treatment zone maintained at a temperature between about 900° C. to about 2000° C. for a contact time of about 0.5 to about 5 seconds. In this aspect, at least a portion of the tar undergoes at least partial oxidation and/or cracking to produce a hot syngas.

    Abstract translation: 提供了一种用于降低焦油含焦油含量的合成气含量的方法和装置。 该方法包括在第一反应区中使包含合成气的焦油与含分子氧的气体接触以产生气体混合物。 气体混合物通过保持在约900℃至约2000℃之间的温度的热处理区，接触时间为约0.5至约5秒。 在这方面，至少一部分焦油经历至少部分氧化和/或开裂以产生热合成气。

    PROCESS AND MEDIUM FOR REDUCING SELENIUM LEVELS IN BIOMASS FROM FERMENTATION OF CO-CONTAINING GASEOUS SUBSTRATES
    10.
    发明申请
    PROCESS AND MEDIUM FOR REDUCING SELENIUM LEVELS IN BIOMASS FROM FERMENTATION OF CO-CONTAINING GASEOUS SUBSTRATES 审中-公开
    用于降低生物量中硒含量的过程和介质来自含有气相底物的发酵

    公开(公告)号：US20150024449A1

    公开(公告)日：2015-01-22

    申请号：US14331326

    申请日：2014-07-15

    Applicant: INEOS BIO SA

    Inventor： Frédéric Kendirgi ,  Ryan H. Senaratne ,  Syrona R. Scott

    IPC: C12P7/06

    Abstract: A process for fermenting syngas and a fermentation medium provides high ethanol productivity while removing medium components that were previously thought to be essential. The process is effective for providing a specific STY of at least about 1 gram of ethanol/(L·day·gram cells) and for providing a selenium content in cell biomass exiting the fermentation of about 1 ppm or less.

    Abstract translation: 发酵合成气和发酵培养基的方法提供高乙醇生产力，同时除去先前被认为是必需的培养基成分。 该方法对于提供至少约1克乙醇/（L·天·克氏细胞）的特定STY和提供约1ppm或更少发酵出的细胞生物质中的硒含量是有效的。

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