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    18 human secreted proteins
    4.
    发明申请
    18 human secreted proteins 失效
    18种人体分泌的蛋白质

    公开(公告)号：US20040235113A1

    公开(公告)日：2004-11-25

    申请号：US10874484

    申请日：2004-06-24

    Applicant: Human Genome Sciences, Inc.

    Inventor： Yanggu Shi ,  Paul E. Young ,  Reinhard Ebner ,  Daniel R. Soppet ,  Steven M. Ruben

    IPC: C07K014/47 ,  C07H021/04

    CPC classification number: C07K14/47

    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

    Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

    Transforming growth factor alpha Hlll
    5.
    发明申请
    Transforming growth factor alpha Hlll 审中-公开
    转化生长因子αHlll

    公开(公告)号：US20040229787A1

    公开(公告)日：2004-11-18

    申请号：US10717473

    申请日：2003-11-21

    Applicant: Human Genome Sciences, Inc.

    Inventor： Ying-Fei Wei

    IPC: A61K038/18 ,  C07H021/04 ,  C07K014/475

    CPC classification number: G01N33/5091 ,  A61K38/1841 ,  C07H21/04 ,  C07K14/495 ,  G01N33/5008 ,  G01N33/502 ,  G01N2500/10

    Abstract: The present invention discloses transforming growth factor alpha HIII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

    Abstract translation: 本发明公开了转化生长因子αHIII多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。

    NUCLEOTIDE SEQUENCE OF THE HAEMOPHILUS INFLUENZAE RD GENOME, FRAGMENTS THEREOF, AND USES THEREOF
    7.
    发明申请
    NUCLEOTIDE SEQUENCE OF THE HAEMOPHILUS INFLUENZAE RD GENOME, FRAGMENTS THEREOF, AND USES THEREOF 失效
    HAEMOPHILUS流感病毒基因组的核苷酸序列，其片段及其用途

    公开(公告)号：US20040203093A1

    公开(公告)日：2004-10-14

    申请号：US10158865

    申请日：2002-06-03

    Applicant: Human Genome Sciences, Inc. ,  Johns Hopkins University

    Inventor： Robert D. Fleischmann ,  Mark D. Adams ,  Owen White ,  Hamilton O. Smith ,  J. Craig Venter

    IPC: C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50 ,  C07H021/04

    CPC classification number: C07K14/285 ,  Y10S435/851

    Abstract: The present invention provides the sequencing of the entire genome of Haemophilus influenzae Rd, SEQ ID NO:1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition to the entire genomic sequence, the present invention identifies over 1700 protein encoding fragments of the genome and identifies, by position relative to a unique Not I restriction endonuclease site, any regulatory elements which modulate the expression of the protein encoding fragments of the Haemophilus genome.

    Abstract translation: 本发明提供了流感嗜血杆菌Rd，SEQ ID NO：1的整个基因组的测序。 本发明还提供存储在计算机可读介质上的序列信息，以及便于其使用的基于计算机的系统和方法。 除了整个基因组序列之外，本发明鉴定了基因组的超过1700个蛋白质编码片段，并且通过相对于独特的Not I限制性内切核酸酶位点的位置鉴定调节嗜血杆菌蛋白编码片段的表达的任何调节元件 基因组

    Stanniocalcin polynucleotides, polypeptides and methods based thereon
    8.
    发明申请
    Stanniocalcin polynucleotides, polypeptides and methods based thereon 审中-公开
    斯坦考钙多核苷酸，多肽和基于此的方法

    公开(公告)号：US20040198658A1

    公开(公告)日：2004-10-07

    申请号：US10614990

    申请日：2003-07-09

    Applicant: Human Genome Sciences, Inc.

    Inventor： Henrik S. Olsen ,  Ke-Zhou Zhang ,  Perttu Lindsberg ,  Turgut Tatlisumak ,  Markku Kaste ,  Leif C. Andersson

    IPC: A61K038/17 ,  A61K033/42

    CPC classification number: C07K14/575 ,  A61K38/00

    Abstract: The present invention relates to human stanniocalcin (STC) polynucleotides, polypeptides, and other Stanniocalcin compositions and to novel methods based thereon. In a specific embodiment, the Stanniocalcin compositions of the invention are used to treat or protect neural cells. Moreover, the present invention relates to vectors, host cells, antibodies, and recombinant and synthetic methods for producing the Stanniocalcin compositions of the invention. Also provided are diagnostic methods for detecting or prognosing diseases, disorders, damage or injury, associated with alterations of the Stanniocalcin compositions of the invention, and to therapeutic methods for treating such diseases, disorders, damage or injury.

    Abstract translation: 本发明涉及人类斯诺钙素（STC）多核苷酸，多肽和其他锡兰钙素组合物以及基于其的新颖方法。 在一个具体的实施方案中，本发明的锡兰钙素组合物用于治疗或保护神经细胞。 此外，本发明涉及载体，宿主细胞，抗体，以及用于生产本发明的斯诺钙素组合物的重组和合成方法。 还提供了用于检测或预测与本发明的耐药性组合物的改变相关的疾病，病症，损伤或损伤的诊断方法以及用于治疗这些疾病，障碍，损伤或损伤的治疗方法。

    Interleukin-1 beta converting enzyme like apoptosis protease-3 and -4
    9.
    发明申请
    Interleukin-1 beta converting enzyme like apoptosis protease-3 and -4 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-3和-4

    公开(公告)号：US20040171059A1

    公开(公告)日：2004-09-02

    申请号：US10801669

    申请日：2004-03-17

    Applicant: Human Genome Sciences, Inc.

    Inventor： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC: C12Q001/68 ,  C07H021/04 ,  C12N009/64

    CPC classification number: C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    Abstract: Disclosed are human interleukin-1 null converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

    Abstract translation: 公开了人白细胞介素-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

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