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1.发明申请公开(公告)号：US20060140982A1
公开(公告)日：2006-06-29
申请号：US11291616
申请日：2005-11-30
申请人： David Roth , Huaping He
发明人： David Roth , Huaping He
IPC分类号： A61K39/04 , C12Q1/68 , G01N33/554 , C07H21/04 , C12N15/74 , G01N33/569 , C07K14/35
CPC分类号： G01N33/5695 , A61K39/00 , A61K39/04 , A61K2039/53 , C07K14/35 , G01N2469/20
摘要： The present invention provides transcriptionally active Mtb polynucleotides, recombinant Mtb peptides and polypeptides, and immunogenic Mtb antigens. Immunogenic compositions are also provided that may be useful as recombinant, subunit and DNA vaccines. In addition the invention provides diagnostic kits for Mtb.
摘要翻译： 本发明提供转录活性Mtb多核苷酸，重组Mtb肽和多肽，以及免疫原性Mtb抗原。 还提供可用作重组，亚单位和DNA疫苗的免疫原性组合物。 此外，本发明提供了用于Mtb的诊断试剂盒。
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公开(公告)号：US20100112008A1
公开(公告)日：2010-05-06
申请号：US12607024
申请日：2009-10-27
申请人： David Roth , Huaping He
发明人： David Roth , Huaping He
CPC分类号： G01N33/5695 , A61K39/00 , A61K39/04 , A61K2039/53 , C07K14/35 , G01N2469/20
摘要： The present invention provides transcriptionally active Mtb polynucleotides, recombinant Mtb peptides and polypeptides, and immunogenic Mtb antigens. Immunogenic compositions are also provided that may be useful as recombinant, subunit and DNA vaccines. In addition the invention provides diagnostic kits for Mtb.
摘要翻译： 本发明提供转录活性Mtb多核苷酸，重组Mtb肽和多肽，以及免疫原性Mtb抗原。 还提供可用作重组，亚单位和DNA疫苗的免疫原性组合物。 此外，本发明提供了用于Mtb的诊断试剂盒。
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3.发明申请Method for Inhibition of Phospholamban Activity for the Treatment of Cardiac Disease and Heart Failure 审中-公开抑制磷脂酰胆碱活性治疗心脏病和心力衰竭的方法公开(公告)号：US20090149412A1
公开(公告)日：2009-06-11
申请号：US12257329
申请日：2008-10-23
申请人： KENNETH CHIEN , WOLFGANG DILLMAN , SUSUMU MINAMISAWA , HUAPING HE , MASAHIKO HOSHIJIMA , MARKUS MEYER , CHRISTOPHER SCOTT , YIBIN WANG , GREGG J. SILVERMAN
发明人： KENNETH CHIEN , WOLFGANG DILLMAN , SUSUMU MINAMISAWA , HUAPING HE , MASAHIKO HOSHIJIMA , MARKUS MEYER , CHRISTOPHER SCOTT , YIBIN WANG , GREGG J. SILVERMAN
IPC分类号： A61K31/7088 , A61P9/00
CPC分类号： A61K38/1709 , A61K47/64
摘要： The present invention provides a method for the treatment of heart failure through the use of small peptide complexes and recombinant proteins which function to enhance contractility in failing hearts and reduce blood pressure in individuals with hypertension by inhibiting the interaction between phospholamban and sacroplasmic reticulum Ca2+ ATPase (SERCA2a) within cardiomyocytes. In addition, a means is provided for the transport of such therapeutic agents into the cytoplasm and nucleus of cardiomyocytes.
摘要翻译： 本发明提供了一种通过使用小肽复合物和重组蛋白来治疗心力衰竭的方法，所述小肽复合物和重组蛋白通过抑制磷脂酰胆碱与骶神经网Ca2 + ATP酶之间的相互作用而起作用以增强失败的心脏的收缩力并降低高血压个体的血压 SERCA2a）在心肌细胞内。 此外，提供了一种用于将这种治疗剂转运到心肌细胞的细胞质和细胞核中的手段。
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4.发明申请公开(公告)号：US20060222658A1
公开(公告)日：2006-10-05
申请号：US11291305
申请日：2005-11-30
申请人： David Roth , Huaping He
发明人： David Roth , Huaping He
CPC分类号： C07K14/005 , A61K39/12 , A61K39/285 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , C12N2710/24122 , C12N2710/24134
摘要： The present invention provides transcriptionally active vaccinia virus polynucleotides, recombinant vaccinia virus polypeptides, and immunogenic vaccinia virus antigens. Immunogenic compositions are also provided that may be useful as recombinant, subunit and DNA vaccines.
摘要翻译： 本发明提供转录活性痘苗病毒多核苷酸，重组痘苗病毒多肽和免疫原性痘苗病毒抗原。 还提供可用作重组，亚单位和DNA疫苗的免疫原性组合物。
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5.发明授权公开(公告)号：US07608277B2
公开(公告)日：2009-10-27
申请号：US11291616
申请日：2005-11-30
申请人： David Roth , Huaping He
发明人： David Roth , Huaping He
CPC分类号： G01N33/5695 , A61K39/00 , A61K39/04 , A61K2039/53 , C07K14/35 , G01N2469/20
摘要： The present invention provides transcriptionally active Mtb polynucleotides, recombinant Mtb peptides and polypeptides, and immunogenic Mtb antigens. Immunogenic compositions are also provided that may be useful as recombinant, subunit and DNA vaccines. In addition, the invention provides diagnostic kits for Mtb.
摘要翻译： 本发明提供转录活性Mtb多核苷酸，重组Mtb肽和多肽，以及免疫原性Mtb抗原。 还提供可用作重组，亚单位和DNA疫苗的免疫原性组合物。 此外，本发明提供了用于Mtb的诊断试剂盒。
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公开(公告)号：US20060224329A1
公开(公告)日：2006-10-05
申请号：US11292185
申请日：2005-11-30
申请人： David Roth , Huaping He , Ben Good
发明人： David Roth , Huaping He , Ben Good
IPC分类号： G06F19/00
摘要： Methods of rapidly generating and analyzing a plurality of polypeptides are disclosed. More specifically, libraries and arrays of polypeptides are assayed in order to determine their individual immunogenic effect. Based on the immunogenic effect of polypeptides, specific subunit vaccines can be developed.
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