公开(公告)号：US20050074904A1

公开(公告)日：2005-04-07

申请号：US10923414

申请日：2004-08-20

申请人： Bryan Chin ,  Zhongyang Cheng ,  Vitaly Vodyanoy ,  James Barbaree ,  Valery Petrenko ,  Tung-Shi Huang ,  Howard Wikle

发明人： Bryan Chin ,  Zhongyang Cheng ,  Vitaly Vodyanoy ,  James Barbaree ,  Valery Petrenko ,  Tung-Shi Huang ,  Howard Wikle

IPC分类号： G01N33/543 ,  G01N33/553

CPC分类号： G01N27/745 ,  G01N33/5434

摘要： A magnetostrictive ligand sensor device (MLSD), system and method are provided having at least one magnetostrictive particle (MSP) to which is bound at least one binding element. The MSP may be dispersed in a sample containing a target ligand such that the target ligand binds thereto. A driver is also provided to emit a varying magnetic field such that the MSP produces a resonance response detectable by a measurement device configured to receive and detect changes in the resonance response that are due to alterations of the binding element. The MLSD and assays find use in identifying and quantitating ligands as well as chemicals and environmental conditions in a sample or patient.

摘要翻译： 提供了具有至少一个磁致伸缩颗粒（MSP）的磁致伸缩配体传感器装置（MLSD），系统和方法，其结合至少一个结合元件。 MSP可以分散在含有靶配体的样品中，使得靶配体与其结合。 还提供驱动器以发射变化的磁场，使得MSP产生由测量装置可检测的共振响应，该测量装置被配置为接收和检测由于绑定元件的改变而引起的共振响应的变化。 MLSD和测定法用于鉴定和定量配体以及样品或患者中的化学物质和环境条件。