公开(公告)号：US09096579B2

公开(公告)日：2015-08-04

申请号：US13864394

申请日：2013-04-17

Applicant: Georg Dahmann ,  Horst Dollinger ,  Christian Gnamm ,  Dennis Fiegen ,  Matthias Hoffmann ,  Jasna Klicic ,  David James Lamb ,  Andreas Schnapp

Inventor： Georg Dahmann ,  Horst Dollinger ,  Christian Gnamm ,  Dennis Fiegen ,  Matthias Hoffmann ,  Jasna Klicic ,  David James Lamb ,  Andreas Schnapp

IPC: A61K31/506 ,  A61K31/551 ,  A61K31/553 ,  A61K31/5386 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D498/10 ,  C07D209/42 ,  C07D403/06 ,  C07D487/04 ,  C07D409/14 ,  C07D403/14 ,  C07D405/14 ,  C07D401/14 ,  C07D413/14 ,  A61K45/06 ,  C07D417/14 ,  C07D471/04 ,  C07D487/10 ,  C07D498/04 ,  C07D513/04

CPC classification number: C07D403/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  C07D209/42 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D498/04 ,  C07D498/10 ,  C07D513/04

Abstract: The invention relates to new amino-indole-substituted imidazolyl-pyrimidines of formula 1 wherein R1, R2, R3, R4 and R5 are defined as in claim 1 and pharmaceutically acceptable salts thereof and the use of these compounds for the preparation of a medicament for treating a disease selected from asthma, COPD, rheumatoid arthritis, specific lymphomas and specific diseases of the nervous system.

Abstract translation: 本发明涉及式1的新的氨基 - 吲哚取代的咪唑基 - 嘧啶，其中R 1，R 2，R 3，R 4和R 5如权利要求1所定义，及其药学上可接受的盐，以及这些化合物用于制备 治疗选自哮喘，COPD，类风湿性关节炎，特异性淋巴瘤和神经系统的特定疾病的疾病。

公开(公告)号：USRE45323E1

公开(公告)日：2015-01-06

申请号：US14175082

申请日：2014-02-07

Applicant: Marc Grundl ,  Horst Dollinger ,  Riccardo Giovannini ,  Christoph Hoenke ,  Matthias Hoffmann ,  Jan Kriegl ,  Domnic Martyres ,  Georg Rast ,  Peter Seither

Inventor： Marc Grundl ,  Horst Dollinger ,  Riccardo Giovannini ,  Christoph Hoenke ,  Matthias Hoffmann ,  Jan Kriegl ,  Domnic Martyres ,  Georg Rast ,  Peter Seither

IPC: A61K31/535 ,  A61K31/445 ,  C07D413/04 ,  C07D413/14 ,  C07D401/04 ,  C07D401/14

CPC classification number: C07D401/04 ,  A61K31/4523 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/56 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

Abstract: Object of the present invention are novel substituted compounds of the formula 1, wherein A, R1, R2, R3 and R4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明的目的是新的取代的式1化合物，其中A，R 1，R 2，R 3和R 4如描述中所定义。 本发明的另一个目的是提供CCR3的拮抗剂，更具体地说是提供包含药用载体和治疗有效量的至少一种本发明化合物或其药学上可接受的盐的药物组合物。

公开(公告)号：US08754073B2

公开(公告)日：2014-06-17

申请号：US12738344

申请日：2008-10-16

Applicant: Pascale Pouzet ,  Ralf Anderskewitz ,  Horst Dollinger ,  Dennis Fiegen ,  Thomas Fox ,  Rolf Goeggel ,  Christoph Hoenke ,  Domnic Martyres ,  Peter Nickolaus ,  Klaus Klinder

Inventor： Pascale Pouzet ,  Ralf Anderskewitz ,  Horst Dollinger ,  Dennis Fiegen ,  Thomas Fox ,  Rolf Goeggel ,  Christoph Hoenke ,  Domnic Martyres ,  Peter Nickolaus ,  Klaus Klinder

IPC: C07D495/04 ,  A61K31/519 ,  A61P29/00 ,  A61P11/06 ,  A61P25/28

CPC classification number: C07D495/04 ,  C07D519/00

Abstract: Piperidinodihydrothienopyrimidines of formula 1 wherein X is SO or SO2 (preferably SO), and R1, R2, R3, and R4 may have the meanings given in the disclosure and claims, pharmacologically acceptable salts thereof, and pharmaceutical compositions containing these compounds. These piperidinodihydrothienopyrimidines are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system, or cancers.

Abstract translation: 其中X为SO或SO 2（优选为SO）的R1为吡啶并二氢噻吩并嘧啶，R1，R2，R3和R4可具有本公开和权利要求书中给出的含义，其药理学上可接受的盐，以及含有这些化合物的药物组合物。 这些哌啶二氢噻吩并嘧啶适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病或癌症。

公开(公告)号：US20130023517A1

公开(公告)日：2013-01-24

申请号：US13596225

申请日：2012-08-28

Applicant: Marc GRUNDL ,  Horst DOLLINGER ,  Riccardo GIOVANNINI ,  Christoph HOENKE ,  Matthias HOFFMANN ,  Jan KRIEGL ,  Domnic MARTYRES ,  Georg RAST ,  Peter SEITHER

Inventor： Marc GRUNDL ,  Horst DOLLINGER ,  Riccardo GIOVANNINI ,  Christoph HOENKE ,  Matthias HOFFMANN ,  Jan KRIEGL ,  Domnic MARTYRES ,  Georg RAST ,  Peter SEITHER

IPC: A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/4725 ,  A61P37/08 ,  A61P11/00 ,  A61P7/00 ,  A61P1/00 ,  A61P31/00 ,  A61P19/02 ,  A61P9/10 ,  A61P11/06 ,  A61P27/02 ,  A61P43/00 ,  A61P9/00 ,  A61K31/5377 ,  A61K31/4709

CPC classification number: C07D401/04 ,  A61K31/4523 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/56 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

Abstract: Object of the present invention are novel substituted compounds of the formula 1, wherein A, R1, R2, R3 and R4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明的目的是新的取代的式1化合物，其中A，R 1，R 2，R 3和R 4如描述中所定义。 本发明的另一个目的是提供CCR3的拮抗剂，更具体地说是提供包含药用载体和治疗有效量的至少一种本发明化合物或其药学上可接受的盐的药物组合物。

公开(公告)号：US07750009B2

公开(公告)日：2010-07-06

申请号：US11282548

申请日：2005-11-18

Applicant: Horst Dollinger ,  Juergen Mack ,  Domnic Martyres ,  Birgit Jung ,  Peter Nickolaus

Inventor： Horst Dollinger ,  Juergen Mack ,  Domnic Martyres ,  Birgit Jung ,  Peter Nickolaus

IPC: C07D487/00 ,  C07D491/00 ,  A61K31/495

CPC classification number: C07D475/08

Abstract: The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.

Abstract translation: 本发明涉及适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统或癌症的疾病以及含有这些化合物的药物组合物的新型蝶啶 。

公开(公告)号：US20100120766A1

公开(公告)日：2010-05-13

申请号：US12689273

申请日：2010-01-19

Applicant: Horst DOLLINGER ,  Domnic MARTYRES ,  Juergen MACK ,  Rolf GOEGGEL ,  Birgit JUNG ,  Peter NICKOLAUS

Inventor： Horst DOLLINGER ,  Domnic MARTYRES ,  Juergen MACK ,  Rolf GOEGGEL ,  Birgit JUNG ,  Peter NICKOLAUS

IPC: A61K31/519 ,  A61K31/5377 ,  A61P11/02 ,  A61P11/00 ,  A61P11/06 ,  A61P1/04 ,  A61P1/00 ,  A61P19/02 ,  A61P29/00 ,  A61P27/02 ,  A61P17/00 ,  A61P35/00 ,  A61P25/02 ,  A61P25/00

CPC classification number: C07D475/08 ,  C07D519/00

Abstract: The invention relates to new pteridines which are suitable for treating respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system and cancers. This invention also relates to pharmaceutical compositions containing these compounds.

Abstract translation: 本发明涉及适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病和癌症的新型蝶啶。 本发明还涉及含有这些化合物的药物组合物。

公开(公告)号：US07648988B2

公开(公告)日：2010-01-19

申请号：US12031396

申请日：2008-02-14

Applicant: Horst Dollinger ,  Domnic Martyres ,  Juergen Mack ,  Peter Nickolaus ,  Birgit Jung

Inventor： Horst Dollinger ,  Domnic Martyres ,  Juergen Mack ,  Peter Nickolaus ,  Birgit Jung

IPC: C07D475/08 ,  A61K31/4985 ,  A61K31/541 ,  A61K31/5355 ,  A61P1/00 ,  A61P11/00 ,  A61P35/00 ,  A61P29/00 ,  A61P25/00 ,  A61P25/02

CPC classification number: C07D475/08

Abstract: Described are new pteridine compounds of the formula 1, where the variables are as described herein. The compounds are useful for the treatment of: respiratory or gastrointestinal complaints or diseases; inflammatory diseases of the joints, skin or eyes; diseases of the peripheral or central nervous system; and cancers. Also described are pharmaceutical compositions which contain these compounds.

Abstract translation: 描述了式1的新的蝶啶化合物，其中变量如本文所述。 该化合物可用于治疗：呼吸道或胃肠道疾病或疾病; 关节，皮肤或眼睛的炎症性疾病; 外周或中枢神经系统疾病; 和癌症。 还描述了含有这些化合物的药物组合物。

公开(公告)号：US07550472B2

公开(公告)日：2009-06-23

申请号：US11282535

申请日：2005-11-18

Applicant: Horst Dollinger ,  Juergen Mack ,  Domnic Martyres ,  Birgit Jung ,  Peter Nickolaus

Inventor： Horst Dollinger ,  Juergen Mack ,  Domnic Martyres ,  Birgit Jung ,  Peter Nickolaus

IPC: A01N43/90 ,  A61K31/519

CPC classification number: C07D475/08

Abstract: The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.

Abstract translation: 本发明涉及适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统或癌症的疾病以及含有这些化合物的药物组合物的新型蝶啶 。

公开(公告)号：US20080153833A1

公开(公告)日：2008-06-26

申请号：US12031396

申请日：2008-02-14

Applicant: Horst Dollinger ,  Juergen Mack ,  Domnic Martyres ,  Birgit Jung ,  Peter Nickolaus

Inventor： Horst Dollinger ,  Juergen Mack ,  Domnic Martyres ,  Birgit Jung ,  Peter Nickolaus

IPC: A61K31/4985 ,  C07D475/00 ,  A61P11/00 ,  A61P1/00 ,  A61P25/00 ,  A61P35/00

CPC classification number: C07D475/08

Abstract: The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.

Abstract translation: 本发明涉及适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统或癌症的疾病以及含有这些化合物的药物组合物的新型蝶啶 。

公开(公告)号：US20070015749A1

公开(公告)日：2007-01-18

申请号：US11533108

申请日：2006-09-19

Applicant: Peter NICKOLAUS ,  Christopher Meade ,  Domnic Martyres ,  Juergen Mack ,  Birgit Jung ,  Horst Dollinger ,  Georg Dahmann

Inventor： Peter NICKOLAUS ,  Christopher Meade ,  Domnic Martyres ,  Juergen Mack ,  Birgit Jung ,  Horst Dollinger ,  Georg Dahmann

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/525

CPC classification number: A61K31/525 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541

Abstract: The invention relates to the use of pteridines for the treatment of inflammatory and obstructive respiratory complaints, preferably asthma or COPD, as well as pharmaceutical compositions containing these compounds.

Abstract translation: 本发明涉及使用蝶啶用于治疗炎性和阻塞性呼吸道感染，优选哮喘或COPD，以及含有这些化合物的药物组合物。