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    Method for preparing taxane derivatives
    1.
    发明授权
    Method for preparing taxane derivatives 有权
    紫杉烷衍生物的制备方法

    公开(公告)号：US08633326B2

    公开(公告)日：2014-01-21

    申请号：US13262936

    申请日：2009-12-03

    Applicant: Sang-Hyun Pyo ,  Jin-Suk Cho ,  Moon-Suk Kim ,  Jai-Young Song ,  Ho-Joon Choi

    Inventor： Sang-Hyun Pyo ,  Jin-Suk Cho ,  Moon-Suk Kim ,  Jai-Young Song ,  Ho-Joon Choi

    IPC: C07D407/00 ,  C07D493/00

    CPC classification number: C07D305/14 ,  Y02P20/55

    Abstract: Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of the stereochemical structure of a selectively separated isomer, which is suitable for producing a taxane derivative in a large scale with high yield.

    Abstract translation: 提供了一种紫杉烷衍生物的制备方法，其包括：使作为侧链的保护基的苯基异丝氨酸衍生物或其异构体的混合物与浆果赤霉素III衍生物或10-脱乙酰基浆果赤霉素III衍生物 得到异构体的混合物; 通过色谱分离异构体; 并进行选择性分离的异构体的立体化学结构的回归，其适用于以高产率大规模生产紫杉烷衍生物。

    Method of detecting bad servo track in hard disk drive
    4.
    发明授权
    Method of detecting bad servo track in hard disk drive 失效
    检测硬盘驱动器中不良伺服轨迹的方法

    公开(公告)号：US08014092B2

    公开(公告)日：2011-09-06

    申请号：US12362688

    申请日：2009-01-30

    Applicant: Ho-Joon Choi ,  Chung-Nae Cho ,  Seung-Taek Lee

    Inventor： Ho-Joon Choi ,  Chung-Nae Cho ,  Seung-Taek Lee

    IPC: G11B27/36

    CPC classification number: G11B27/36 ,  G11B2220/2516

    Abstract: A method of detecting a bad servo track of an HDD includes measuring servo AGC of each of servo sectors of a servo track requiring determination of badness, calculating statistic data with respect to the measured servo AGC of each servo sector, and determining whether the servo track is bad based on the calculated statistic data. Since the badness of a servo track is determined based on the statistic data of the servo AGC, a bad servo track generated due to a change in the overall magnitude of a servo signal is easily detected so that reliability in the detection of a detective servo track can be improved.

    Abstract translation: 一种检测HDD的不良伺服轨迹的方法包括测量需要确定不良的伺服轨迹的每个伺服扇区的伺服AGC，针对每个伺服扇区的测量伺服AGC计算统计数据，以及确定伺服轨迹 根据计算出的统计数据是不好的。 由于基于伺服AGC的统计数据来确定伺服轨迹的不良情况，容易检测由于伺服信号的总体幅度的变化而产生的不良伺服磁道，从而可以检测检测伺服磁道 可以改进。

    Method for purification of paclitaxel from paclitaxel-containing materials
    5.
    发明申请
    Method for purification of paclitaxel from paclitaxel-containing materials 有权
    从含紫杉醇的材料中纯化紫杉醇的方法

    公开(公告)号：US20050154218A1

    公开(公告)日：2005-07-14

    申请号：US11028487

    申请日：2004-12-30

    Applicant: Sang-Hyun Pyo ,  Moon-Suk Kim ,  Jin-Suk Cho ,  Bong-Kyu Song ,  Ho-Joon Choi

    Inventor： Sang-Hyun Pyo ,  Moon-Suk Kim ,  Jin-Suk Cho ,  Bong-Kyu Song ,  Ho-Joon Choi

    IPC: C07D305/14 ,  C07D35/12

    CPC classification number: C07D305/14

    Abstract: This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extract; (b) adding the concentrate with an organic solvent which is not mixed with water to separate an organic solvent phase and then concentrating; (c) subjecting the concentrate to normal phase chromatography to obtain an eluate; (d) dissolving the eluate in an acetone or dichloromethane followed by adding pentane or hexane to form a precipitate; and (e) subjecting the precipitate to high performance liquid chromatography. According to the method of the present invention, paclitaxel of over 99.5% purity can be easily obtained from a Taxus genus plant with a high yield.

    Abstract translation: 本发明涉及从含紫杉醇的材料中纯化紫杉醇的方法。 该方法包括以下步骤：（a）用有机溶剂萃取含有紫杉醇的材料，得到提取物，浓缩提取物; （b）将浓缩物与不与水混合的有机溶剂加入以分离有机溶剂相，然后浓缩; （c）使浓缩物进行正相色谱以获得洗脱液; （d）将洗脱液溶解在丙酮或二氯甲烷中，然后加入戊烷或己烷以形成沉淀物; 和（e）使沉淀物进行高效液相色谱。 根据本发明的方法，可以容易地从具有高收率的紫杉属植物获得纯度超过99.5％的紫杉醇。

    Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medium
    6.
    发明授权
    Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medium 有权
    通过处理培养基中的糖混合物，在植物细胞培养中大量生产次生代谢物

    公开(公告)号：US08936940B2

    公开(公告)日：2015-01-20

    申请号：US11915869

    申请日：2006-06-02

    Applicant: Jin-Ah Kim ,  Chang-Heon Kim ,  Jai-Young Song ,  Ho-Joon Choi

    Inventor： Jin-Ah Kim ,  Chang-Heon Kim ,  Jai-Young Song ,  Ho-Joon Choi

    IPC: C12N5/00 ,  C12N5/02 ,  C12N1/38 ,  C12P17/02

    CPC classification number: C12N5/0025 ,  C12N1/38 ,  C12P17/02

    Abstract: The present invention relates to a method of producing secondary metabolites with a high yield using plant cell culture, and a medium for the production of secondary metabolites. More specifically, the method of the present invention is characterized in that the plant cell culture is conducted by adding a saccharide mixture to the culture medium as a carbon source, to increase the productivity of the secondary metabolites. For example, the present invention establishes the method of increasing the productivity of secondary metabolites and shortening the culture time by the use of the mixture of glucose and fructose in the plant cell culture, thereby contributing in producing useful secondary metabolites on an industrial scale using plant cell culture.

    Abstract translation: 本发明涉及使用植物细胞培养物产生高产率的次级代谢产物的方法和用于生产次级代谢产物的培养基。 更具体地说，本发明的方法的特征在于，通过向作为碳源的培养基中添加糖混合物来进行植物细胞培养，以提高次级代谢物的生产率。 例如，本发明建立了通过在植物细胞培养物中使用葡萄糖和果糖的混合物来提高次级代谢产物的生产率并缩短培养时间的方法，从而有助于在工业规模上使用植物生产有用的次级代谢物 细胞培养。

    METHOD OF FORMING REFERENCE PATTERN
    8.
    发明申请
    METHOD OF FORMING REFERENCE PATTERN 审中-公开
    形成参考图案的方法

    公开(公告)号：US20090195915A1

    公开(公告)日：2009-08-06

    申请号：US12330615

    申请日：2008-12-09

    Applicant: Ho-chul SHIN ,  Ho-joon CHOI

    Inventor： Ho-chul SHIN ,  Ho-joon CHOI

    IPC: G11B5/596

    CPC classification number: G11B5/59633 ,  G11B5/59638

    Abstract: A method of forming a reference pattern. The method includes: determining whether a boundary point of an initial reference pattern is located at an inner diameter region of a disk, which is inside an outermost circumferential track; and if the boundary point of the initial reference pattern is located at the inner diameter region of the disk, additionally forming a compensated reference pattern integrally with the initial reference pattern so that a final reference pattern extends in the direction of an outer diameter of the disk. The method allows compensation for a defective reference pattern into an effective reference pattern by extending the initial reference pattern according to whether the boundary point of the initial reference pattern is located inside the outermost circumferential track of the disk.

    Abstract translation: 一种形成参考图案的方法。 该方法包括：确定初始参考图案的边界点是否位于最外圆周轨道内的盘的内径区域; 并且如果初始参考图案的边界点位于盘的内径区域，则另外形成与初始参考图案一体的补偿参考图案，使得最终参考图案沿盘的外径方向延伸 。 该方法允许通过根据初始参考图案的边界点是否位于盘的最外圆周轨道内的方式扩展初始参考图案来将缺陷参考图案补偿为有效参考图案。

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