公开(公告)号：US20100168380A1

公开(公告)日：2010-07-01

申请号：US12593221

申请日：2008-03-26

Applicant: Hiroaki Suga ,  Hiroshi Murakami ,  Yuki Goto ,  Yusuke Yamagishi ,  Hiroshi Ashigai ,  Yusuke Sako

Inventor： Hiroaki Suga ,  Hiroshi Murakami ,  Yuki Goto ,  Yusuke Yamagishi ,  Hiroshi Ashigai ,  Yusuke Sako

IPC: C07K1/00 ,  C12P21/00

CPC classification number: C07K7/56 ,  C07K7/06 ,  C07K7/08 ,  C12N15/67 ,  C12P21/02

Abstract: The objective is to provide a novel process for synthesizing a cyclic peptide compound. It is also an objective to provide a novel cyclic peptide compound. The novel process for synthesizing a cyclic peptide compound comprises the steps of: (1) translationally synthesizing a non-cyclic peptide compound having in a molecule a functional group 1 and a functional group 2, which are a pair of functional groups capable of reacting to form a bond, and (2) cyclizing the non-cyclic peptide compound by the reaction of the functional groups 1 and 2 to form a bond. The novel cyclic peptide compound can be synthesized by the process.

Abstract translation: 目的是提供一种合成环肽化合物的新方法。 提供新的环肽化合物也是目的。 用于合成环肽化合物的新方法包括以下步骤：（1）在分子中转化合成具有官能团1和官能团2的能够对 形成键，和（2）通过官能团1和2的反应使非环肽化合物环化以形成键。 可以通过该方法合成新的环肽化合物。

公开(公告)号：US20120058529A1

公开(公告)日：2012-03-08

申请号：US13202820

申请日：2010-02-23

Applicant: Shigehito Ikushima ,  Toshio Fujii ,  Osamu Kobayashi ,  Hiroshi Ashigai

Inventor： Shigehito Ikushima ,  Toshio Fujii ,  Osamu Kobayashi ,  Hiroshi Ashigai

IPC: C12P7/56 ,  C12N1/19

CPC classification number: C12N9/0006 ,  C12P7/56

Abstract: There is disclosed a yeast strain of Candida utilis, wherein the yeast strain has been transformed with at least one copy of a gene that is operatively linked to a promoter sequence enabling expression of the gene and encodes a polypeptide having activity of lactate dehydrogenase. The yeast strain is useful for producing lactic acid with high efficiency.

Abstract translation: 公开了产朊假丝酵母的酵母菌株，其中已经用至少一个拷贝的基因转化了酵母菌株，该拷贝与启动子序列可操作地连接，使得能够表达基因并编码具有乳酸脱氢酶活性的多肽。 酵母菌株可用于高效生产乳酸。

公开(公告)号：US09090668B2

公开(公告)日：2015-07-28

申请号：US12593221

申请日：2008-03-26

Applicant: Hiroaki Suga ,  Hiroshi Murakami ,  Yuki Goto ,  Yusuke Yamagishi ,  Hiroshi Ashigai ,  Yusuke Sako

Inventor： Hiroaki Suga ,  Hiroshi Murakami ,  Yuki Goto ,  Yusuke Yamagishi ,  Hiroshi Ashigai ,  Yusuke Sako

IPC: C07K7/56 ,  C07K7/06 ,  C07K7/08 ,  C12N15/67 ,  C12P21/02

CPC classification number: C07K7/56 ,  C07K7/06 ,  C07K7/08 ,  C12N15/67 ,  C12P21/02

Abstract: The objective is to provide a novel process for synthesizing a cyclic peptide compound. It is also an objective to provide a novel cyclic peptide compound. The novel process for synthesizing a cyclic peptide compound comprises the steps of: (1) translationally synthesizing a non-cyclic peptide compound having in a molecule a functional group 1 and a functional group 2, which are a pair of functional groups capable of reacting to form a bond, and (2) cyclizing the non-cyclic peptide compound by the reaction of the functional groups 1 and 2 to form a bond. The novel cyclic peptide compound can be synthesized by the process.

Abstract translation: 目的是提供一种合成环肽化合物的新方法。 提供新的环肽化合物也是目的。 用于合成环肽化合物的新方法包括以下步骤：（1）在分子中转化合成具有官能团1和官能团2的非环状肽化合物，所述官能团是能够使 形成键，和（2）通过官能团1和2的反应使非环肽化合物环化以形成键。 可以通过该方法合成新的环肽化合物。