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公开(公告)号：US08907057B2
公开(公告)日：2014-12-09
申请号：US14175387
申请日：2014-02-07
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
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公开(公告)号：US20140248334A1
公开(公告)日：2014-09-04
申请号：US14175471
申请日：2014-02-07
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
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公开(公告)号：US08674071B2
公开(公告)日：2014-03-18
申请号：US12864895
申请日：2009-01-30
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
摘要翻译： 本发明涉及使用靶向背根神经节（DRG）神经元的肽的方法和组合物。 特别地，肽例如用于将治疗剂，例如蛋白质，脂质体或包含治疗性多核苷酸的病毒颗粒靶向一种或多种外周神经病或神经性疼痛。 在特殊情况下，周围神经病变或神经性疼痛直接或间接地由DRG神经元病变引起。
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公开(公告)号：US20110189263A1
公开(公告)日：2011-08-04
申请号：US12864895
申请日：2009-01-30
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
IPC分类号： A61K9/127 , C07K7/06 , A61K38/08 , C07K19/00 , A61K35/76 , A61K38/20 , C07H21/00 , A61P25/00 , A61P35/00 , A61P31/00 , A61P3/00
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
摘要翻译： 本发明涉及使用靶向背根神经节（DRG）神经元的肽的方法和组合物。 特别地，肽例如用于将治疗剂，例如蛋白质，脂质体或包含治疗性多核苷酸的病毒颗粒靶向一种或多种外周神经病或神经性疼痛。 在特殊情况下，周围神经病变或神经性疼痛直接或间接地由DRG神经元病变引起。
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公开(公告)号：US08859728B2
公开(公告)日：2014-10-14
申请号：US14175471
申请日：2014-02-07
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
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公开(公告)号：US20140227348A1
公开(公告)日：2014-08-14
申请号：US14175387
申请日：2014-02-07
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
摘要翻译： 本发明涉及使用靶向背根神经节（DRG）神经元的肽的方法和组合物。 特别地，肽例如用于将治疗剂，例如蛋白质，脂质体或包含治疗性多核苷酸的病毒颗粒靶向一种或多种外周神经病或神经性疼痛。 在特殊情况下，周围神经病变或神经性疼痛直接或间接地由DRG神经元病变引起。
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7.发明授权Semiconductor integrated circuit with electrode pad suited for a characteristic testing 失效具有适用于特性测试的电极焊盘的半导体集成电路
公开(公告)号：US4223337A
公开(公告)日：1980-09-16
申请号：US942730
申请日：1978-09-15
申请人： Hideto Kojima , Hisashi Funakoshi
发明人： Hideto Kojima , Hisashi Funakoshi
IPC分类号： H01L23/52 , H01L21/3205 , H01L23/485 , H01L23/58 , H01L23/48 , H01L29/44 , H01L29/52
CPC分类号： H01L24/05 , H01L22/32 , H01L24/48 , H01L2224/04042 , H01L2224/05553 , H01L2224/05624 , H01L2224/45014 , H01L2224/45124 , H01L2224/45144 , H01L2224/48463 , H01L2224/48624 , H01L2224/48724 , H01L2224/85424 , H01L24/45 , H01L2924/00014 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/0106 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/19041 , H01L2924/19043 , H01L2924/30105 , H01L2924/3025
摘要： An integrated circuit device is provided with a divided electrode pad which permits checking the electrical characteristics of individual circuit elements before assembly into a package housing. After testing, the divided electrode pad is connected by thermally bonding one end of a single lead wire or the like to the divided parts.
摘要翻译： 集成电路器件设置有分开的电极焊盘，其允许在组装到封装壳体之前检查各个电路元件的电特性。 在测试之后，通过将单根引线等的一端热粘合到分割部分来连接分开的电极焊盘。
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