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公开(公告)号：US09126931B2
公开(公告)日：2015-09-08
申请号：US13377300
申请日：2010-06-09
申请人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yasuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
发明人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yasuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
IPC分类号： C07D207/30 , C07D209/80 , C07D333/50 , C07D307/77 , C07D209/56 , C07D209/88 , C07D307/92 , C07D333/76 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/107
CPC分类号： C07D209/58 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/7056 , C07D209/56 , C07D209/88 , C07D307/77 , C07D307/78 , C07D307/92 , C07D333/50 , C07D333/52 , C07D333/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/107 , C07F7/0834 , C07H15/26
摘要： A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
摘要翻译： 由下述通式（I）表示的化合物或其盐或溶剂化物，其可用作ALK抑制剂，并且可用于预防或治疗伴有ALK异常的疾病，例如癌症，癌症转移 ，抑郁症或认知功能障碍（包括在公式中的符号的含义如说明书中所给出）。
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公开(公告)号：US20120083488A1
公开(公告)日：2012-04-05
申请号：US13377300
申请日：2010-06-09
申请人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yashuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
发明人： Kazutomo Kinoshita , Kohsuke Asoh , Noriyuki Furuichi , Toshiya Ito , Hatsuo Kawada , Nobuya Ishii , Hiroshi Sakamoto , WooSang Hong , MinJeong Park , Yoshiyuki Ono , Yashuharu Kato , Kenji Morikami , Takashi Emura , Nobuhiro Oikawa
IPC分类号： A61K31/454 , C07D405/12 , C07D413/12 , C07D417/10 , C07D403/10 , C07D409/10 , C07D209/80 , C07D471/04 , C07D491/048 , C07D401/10 , C07D401/14 , C07D491/107 , C07D413/14 , C07D417/12 , A61K31/55 , A61K31/343 , A61K31/506 , A61K31/4525 , A61K31/4025 , A61K31/496 , A61K31/443 , A61K31/4178 , A61K31/5377 , A61K31/427 , A61K31/4155 , A61K31/403 , A61K31/4355 , A61K31/407 , A61K31/541 , A61K31/4545 , A61P35/00 , A61P35/04 , A61P25/24 , A61P25/28 , A61K31/437 , C07D307/77
CPC分类号： C07D209/58 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/7056 , C07D209/56 , C07D209/88 , C07D307/77 , C07D307/78 , C07D307/92 , C07D333/50 , C07D333/52 , C07D333/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/107 , C07F7/0834 , C07H15/26
摘要： A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
摘要翻译： 由下述通式（I）表示的化合物或其盐或溶剂化物，其可用作ALK抑制剂，并且可用于预防或治疗伴有ALK异常的疾病，例如癌症，癌症转移 ，抑郁症或认知功能障碍（包括在公式中的符号的含义如说明书中所给出）。
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公开(公告)号：US08022205B2
公开(公告)日：2011-09-20
申请号：US12376039
申请日：2007-08-07
申请人： Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
发明人： Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
IPC分类号： C07D401/04 , C07D401/12 , C07D405/04 , C07D413/12
CPC分类号： C07D487/04
摘要： A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility.A compound, or pharmaceutically acceptable salt thereof, represented by formula (I): [wherein, X represents a single bond, etc.; Y represents a single bond, etc. (provided that X and Y are not simultaneously single bonds); Z represents a hydrogen atom, etc.; m represents an integer of 1 or 2; and R1 represents a cyclic substituent].
摘要翻译： 由于具有优异的PI3K抑制作用以及在体内具有优异的稳定性和水溶性，因此提供了可用作癌症的预防或治疗剂的药物。 由式（I）表示的化合物或其药学上可接受的盐：[其中，X表示单键等; Y表示单键等（X和Y不同时为单键）。 Z表示氢原子等; m表示1或2的整数; 并且R 1表示环状取代基]。
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公开(公告)号：US20100069629A1
公开(公告)日：2010-03-18
申请号：US12376039
申请日：2007-08-07
申请人： Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
发明人： Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
IPC分类号： C07D413/14 , A61P35/00
CPC分类号： C07D487/04
摘要： A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility.A compound, or pharmaceutically acceptable salt thereof, represented by formula (I): [wherein, X represents a single bond, etc.; Y represents a single bond, etc. (provided that X and Y are not simultaneously single bonds); Z represents a hydrogen atom, etc.; m represents an integer of 1 or 2; and R1 represents a cyclic substituent].
摘要翻译： 由于具有优异的PI3K抑制作用以及在体内具有优异的稳定性和水溶性，因此提供了可用作癌症的预防或治疗剂的药物。 由式（I）表示的化合物或其药学上可接受的盐：[其中，X表示单键等; Y表示单键等（X和Y不同时为单键）。 Z表示氢原子等; m表示1或2的整数; 并且R 1表示环状取代基]。
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