Invention Grant
- Patent Title: Pyrimidine derivatives as PI3K inhibitor and use thereof
- Patent Title (中): 嘧啶衍生物作为PI3K抑制剂及其用途
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Application No.: US12376039Application Date: 2007-08-07
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Publication No.: US08022205B2Publication Date: 2011-09-20
- Inventor: Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
- Applicant: Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Foley & Lardner LLP
- Priority: JP2006-216108 20060808; JP2007-118631 20070427
- International Application: PCT/JP2007/065396 WO 20070807
- International Announcement: WO2008/018426 WO 20080214
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D401/12 ; C07D405/04 ; C07D413/12
Abstract:
A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility.A compound, or pharmaceutically acceptable salt thereof, represented by formula (I): [wherein, X represents a single bond, etc.; Y represents a single bond, etc. (provided that X and Y are not simultaneously single bonds); Z represents a hydrogen atom, etc.; m represents an integer of 1 or 2; and R1 represents a cyclic substituent].
Public/Granted literature
- US20100069629A1 PYRIMIDINE DERIVATIVES AS PI3K INHIBITOR AND USE THEREOF Public/Granted day:2010-03-18
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