公开(公告)号：US5026537A

公开(公告)日：1991-06-25

申请号：US334459

申请日：1989-04-06

Applicant: Peter E. Daddona ,  Harvey J. Berger ,  Rodger P. McEver

Inventor： Peter E. Daddona ,  Harvey J. Berger ,  Rodger P. McEver

IPC: A61K51/00 ,  A61K51/10 ,  G01N33/53 ,  G01N33/577

CPC classification number: A61K51/1018 ,  A61K2123/00 ,  Y10S424/809 ,  Y10S530/866

Abstract: This invention pertains to a method of imaging atherosclerotic plaque using radiolabeled monoclonal antibodies that are specific for activated platelets or activated endothelial cells. The method is capable of determining the site of endothelial injury. This method involves the administration of a platelet-specific labeled monoclonal antibody or antibody fragment to a patient. The antibody is allowed to accumulate at the plaque site and the plaque is then scanned with a photoscanner. The detected signals are then converted into an image of the plaque.

Abstract translation: 本发明涉及使用对活化的血小板或活化的内皮细胞特异的放射性标记的单克隆抗体成像动脉粥样硬化斑块的方法。 该方法能够确定内皮损伤部位。 该方法涉及向患者施用血小板特异性标记的单克隆抗体或抗体片段。 允许抗体在斑块部位积聚，然后用照相扫描仪扫描斑块。 然后将检测到的信号转换成斑块的图像。

公开(公告)号：US4952393A

公开(公告)日：1990-08-28

申请号：US254961

申请日：1988-10-07

Applicant: Harvey J. Berger ,  Ban A. Khaw ,  Koon Y. Pak ,  H. William Strauss

Inventor： Harvey J. Berger ,  Ban A. Khaw ,  Koon Y. Pak ,  H. William Strauss

IPC: A61K51/00 ,  A61K51/04 ,  A61K51/10 ,  A61K49/02 ,  C07F13/00

CPC classification number: A61K51/0491 ,  A61K51/1018 ,  A61K2123/00

Abstract: Method using technetium-99m imaging agents for the study, detection or diagnosis of ischemic, infarcted or diseased tissue. The imaging agents comprise a complex of technetium-99 m and glucarate.

Abstract translation: 使用锝-99m成像剂进行缺血性，梗死或患病组织的研究，检测或诊断的方法。 成像剂包括锝-99m和葡糖二酸的复合物。

公开(公告)号：US5046499A

公开(公告)日：1991-09-10

申请号：US206437

申请日：1988-06-13

Applicant: Harvey J. Berger

Inventor： Harvey J. Berger

IPC: A61K51/00 ,  A61K49/00 ,  A61K51/08

CPC classification number: A61K49/0004 ,  A61K2123/00

Abstract: The invention pertains to a method quantitative localization of antimyosin uptake in the myocardium of a patient as an indication of myocardial infarction from a plurality of planar projections displayed simultaneously. The invention also pertains to a method for screening patients with chest pain due to myocardial ischemia to identify patients having a high risk of developing myocardial infarction.

Abstract translation: 本发明涉及一种方法，定量定位患者心肌中的抗肌球蛋白摄取，作为同时显示的多个平面投影的心肌梗塞指征。 本发明还涉及一种用于筛选由于心肌缺血引起的胸痛患者的方法，以鉴定发生心肌梗死风险高的患者。

公开(公告)号：US5024829A

公开(公告)日：1991-06-18

申请号：US274383

申请日：1988-11-21

Applicant: Harvey J. Berger ,  Jamshid Maddahi ,  Daniel Berman

Inventor： Harvey J. Berger ,  Jamshid Maddahi ,  Daniel Berman

IPC: A61K51/00 ,  A61K51/10

CPC classification number: A61K51/1018 ,  A61K2123/00 ,  Y10S424/809 ,  Y10S530/866

Abstract: A method for instantaneous imaging of coronary thrombi is disclosed. A radiolabeled, thrombus-specific antibody or antibody fragment is administered into a coronary artery and the label is detected to obtain a visual image of the thrombus.

Abstract translation: 公开了一种用于冠状动脉血栓的瞬时成像的方法。 将放射性标记的血栓特异性抗体或抗体片段施用于冠状动脉，并检测标记物以获得血栓的视觉图像。