公开(公告)号：US20070196813A1

公开(公告)日：2007-08-23

申请号：US11626518

申请日：2007-01-24

申请人： Jochen Franzen ,  Hans-Jakob Baum ,  Karsten Michelmann

发明人： Jochen Franzen ,  Hans-Jakob Baum ,  Karsten Michelmann

IPC分类号： C12Q1/00 ,  G01N33/567 ,  C12M3/00 ,  A61M1/06

CPC分类号： A61B5/150793 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/150755 ,  A61B5/150786 ,  B01L2200/185 ,  B01L2300/069 ,  G01N1/405 ,  G01N33/6848

摘要： In a method for preparing a blood sample for subsequent processing in a mass spectrometry laboratory, substances of interest are extracted from whole blood, blood plasma or blood serum immediately after the blood sample has been taken from a subject. The extraction is carried out by means of reversible immobilization on a surface, for example, the surface of a blood extraction vessel. Only the extracted substances of interest are sent in the immobilized state to the mass spectrometry laboratory.

摘要翻译： 在用于制备用于随后在质谱实验室中处理的血液样品的方法中，在从受试者取出血液样本后，立即从全血，血浆或血清中提取目的物质。 通过可逆地固定在表面上，例如血液提取容器的表面进行提取。 将所提取的目的物质以固定状态送入质谱实验室。

公开(公告)号：US07615343B2

公开(公告)日：2009-11-10

申请号：US10824656

申请日：2004-04-14

申请人： Jochen Franzen ,  Hans-Jakob Baum

发明人： Jochen Franzen ,  Hans-Jakob Baum

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/00

CPC分类号： C12Q1/6816 ,  G01N27/3278 ,  C12Q2563/143 ,  C12Q2565/607

摘要： The invention relates to the detection of the binding of analyte molecules, for example biopolymer molecules, to immobilized capture substance molecules. The invention consists in using semiconductor wafers (chips) with electrical circuits in spatial proximity to a surface area coated with capture substance molecules and loading the binding of the analyte molecules to the capture substance molecules with co-bound electrically conductive nanoparticles so that the nanoparticles can act upon the electrical circuits either through changes in the electrical stray capacitance or by generating electric currents, thus making the binding of the analyte molecules electronically detectable.

摘要翻译： 本发明涉及检测分析物分子例如生物聚合物分子与固定的捕获物质分子的结合。 本发明包括使用半导体晶片（芯片）与电路在空间上接近涂覆有捕获物质分子的表面区域，并将分析物分子与共结合导电纳米粒子的结合加载，使得纳米颗粒可以 通过电杂散电容的变化或通过产生电流对电路施加作用，从而使分析物分子的电子可检测结合。

公开(公告)号：US4982616A

公开(公告)日：1991-01-08

申请号：US421260

申请日：1989-10-13

申请人： Dieter Koch ,  Hans-Jakob Baum

发明人： Dieter Koch ,  Hans-Jakob Baum

IPC分类号： G01N1/02 ,  G01N1/10 ,  G01N30/00

CPC分类号： F41H7/03 ,  G01N1/02 ,  G01N1/10 ,  G01N30/00 ,  G01N2001/028

摘要： A sampling device for inspection vehicles equipped with an environmental inspection system, the system comprising an analyzer having a receiving head (21), to which the substances to be examined are supplied by means of a movable collecting body (4) having a ground-engageable contact surface. The collecting body is formed by a rope-like material (4) which is wound up on a supply drum (2) and passed between two rollers (10, 11) arranged at a certain distance therefrom. By displacing the material (4) in its longitudinal direction, the material can be moved into a first position in which an end section (41) of the material hangs down and contacts the ground (42), and a second position in which the end section (41), which had been in contact with the ground (42), is positioned opposite the receiving head (21). Consumed end portions (41) can be cut off by means of a separating device.

摘要翻译： 一种配备有环境检查系统的检查车辆的采样装置，该系统包括具有接收头（21）的分析器，待检查物质借助于可移动的收集体（4）供应到该接收头 接触面。 收集体由卷绕在供给滚筒（2）上的绳状材料（4）形成，并通过设置在一定距离处的两个辊（10,11）之间。 通过使材料（4）沿其纵向方向移位，材料可以移动到第一位置，在第一位置，材料的端部（41）垂下并接触地面（42），第二位置 已经与地面（42）接触的部分（41）位于接收头（21）的对面。 消耗端部（41）可以通过分离装置切断。