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公开(公告)号：US11413335B2
公开(公告)日：2022-08-16
申请号：US15895468
申请日：2018-02-13
发明人： Shuang Chen , Yufu Li , Aibin Yu , Jianping Yu
IPC分类号： A61K38/36 , A61K38/48 , A61K31/717 , A61K9/16 , A61P11/00 , A61K9/00 , A61K9/06 , A61L24/10 , A61L24/08
摘要： The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent, agitating and shearing said suspension in a high shear mixing reactor, adding water to allow particles to agglomerate, allowing the non-aqueous solvent to evaporate, drying and sieving the composition; and thus forming the powdered hemostatic composition.
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公开(公告)号：US11229720B2
公开(公告)日：2022-01-25
申请号：US15258549
申请日：2016-09-07
发明人： Shuang Chen , Yufu Li , Dengmin Feng , Xiang Wan
IPC分类号： A61L24/10 , A61K9/16 , A61K31/717 , A61K38/36 , A61K38/48 , A61K47/18 , A61L24/00 , A61L24/02 , A61L24/08 , C08J3/12
摘要： The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated oxidized regenerated cellulose (ORC) fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition.
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公开(公告)号：USD877890S1
公开(公告)日：2020-03-10
申请号：US29644637
申请日：2018-06-06
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4.发明公开公开(公告)号：US20240350126A1
公开(公告)日：2024-10-24
申请号：US18700441
申请日：2021-09-10
发明人： SHIWEI XIE , JIANXIN GUO , YUFU LI , XUELIN GUO , SAMANTHA WEBER
IPC分类号： A61B17/00
CPC分类号： A61B17/00491 , A61B2017/00495 , A61B2017/00522
摘要： A combined powder and liquid delivery device includes a housing having a powder chamber and a liquid chamber. The device includes an applicator tip having a powder delivery channel extending between a proximal end and a distal end of the applicator tip that is in fluid communication with the powder chamber, and a liquid delivery channel that extends from the proximal to the distal end of the applicator tip that is in fluid communication with the liquid chamber. The delivery device includes a powder inlet port in fluid communication with the powder chamber, and a liquid inlet port in fluid communication with the liquid chamber. A powder delivery system is in fluid communication with the powder inlet port, the powder chamber, and the powder delivery channel. A liquid delivery system is in fluid communication with the liquid inlet port, the liquid chamber, and the liquid delivery channel.
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公开(公告)号：US10918790B2
公开(公告)日：2021-02-16
申请号：US15623791
申请日：2017-06-15
发明人： Michael J. Trezza , John Goodman
摘要： The present invention is directed to multi-liquid loading and delivery kits comprising a first storage vessel for a first active component, a second storage vessel for a second active component, at least two transfer syringes, at least two vial adaptors, at least two cannulas with a through lumen and a multi-liquid delivery device. The delivery device has dual hollow cartridges, each with at least one throughbore at one end and plunger access at the opposing end, a kick stand, a removable dual feed funnel, a spray or drip manifold and at least one spray or drip tip assembly.
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公开(公告)号：US10538754B2
公开(公告)日：2020-01-21
申请号：US15547839
申请日：2015-02-06
发明人： Lior Weissman , Dana Sella , Israel Nur , Caixia Jiang , Baochang An
摘要： The present invention is directed to methods for the production of thrombin from a source of prothrombin using a given BaSO4 reagent as an adsorbent of prothrombin as well as methods for evaluating the suitability of a given BaSO4 reagent for use in preparation of thrombin. In at least one embodiment, the method includes contacting a sample of the given BaSO4 reagent with a source of prothrombin to obtain BaSO4-adsorbed prothrombin, and subsequently evaluating the pro-coagulant activity of the BaSO4-adsorbed prothrombin. In another embodiment, the method includes the step of evaluating relative to the pro-coagulant activity of normal mammalian plasma.
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公开(公告)号：US20180043054A1
公开(公告)日：2018-02-15
申请号：US15258549
申请日：2016-09-07
发明人： Shuang Chen , Yufu Li , Dengmin Feng , Xiang Wan
IPC分类号： A61L24/10 , A61K38/36 , A61K38/48 , C08J3/12 , A61K47/18 , A61L24/02 , A61L24/00 , A61L24/08 , A61K9/16 , A61K31/717
摘要： The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition.
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公开(公告)号：US11998656B2
公开(公告)日：2024-06-04
申请号：US17549131
申请日：2021-12-13
发明人： Shuang Chen , Yufu Li , Dengmin Feng , Xiang Wan
IPC分类号： A61L24/10 , A61K9/16 , A61K31/717 , A61K38/36 , A61K38/48 , A61K47/18 , A61L24/00 , A61L24/02 , A61L24/08 , C08J3/12
CPC分类号： A61L24/108 , A61K9/16 , A61K9/1611 , A61K9/1682 , A61K31/717 , A61K38/363 , A61K38/4833 , A61K47/18 , A61L24/0042 , A61L24/02 , A61L24/08 , A61L24/106 , C08J3/12 , C12Y304/21005 , A61L2300/232 , A61L2300/252 , A61L2300/418 , A61L2300/802 , A61L2400/04 , A61L2430/36 , C08J2301/02 , C08J2389/00
摘要： The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition.
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公开(公告)号：US20220096708A1
公开(公告)日：2022-03-31
申请号：US17549131
申请日：2021-12-13
发明人： Shuang Chen , Yufu Li , Dengmin Feng , Xiang Wan
IPC分类号： A61L24/10 , A61K9/16 , A61K31/717 , A61K38/36 , A61K38/48 , A61K47/18 , A61L24/00 , A61L24/02 , A61L24/08 , C08J3/12
摘要： The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition.
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公开(公告)号：US20210121630A1
公开(公告)日：2021-04-29
申请号：US17143485
申请日：2021-01-07
发明人： MICHAEL J. TREZZA , John Goodman
摘要： The present invention is directed to multi-liquid loading and delivery kits comprising a first storage vessel for a first active component, a second storage vessel for a second active component, at least two transfer syringes, at least two vial adaptors, at least two cannulas with a through lumen and a multi-liquid delivery device. The delivery device has dual hollow cartridges, each with at least one throughbore at one end and plunger access at the opposing end, a kick stand, a removable dual feed funnel, a spray or drip manifold and at least one spray or drip tip assembly.
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