公开(公告)号：US20090170790A1

公开(公告)日：2009-07-02

申请号：US11577900

申请日：2005-10-25

申请人： Biswajit Das ,  Mohammad Salman ,  Santosh Haribhau Kurhade ,  Ramadass Venkataramanan ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Rita Katoch ,  Anish Bandyopadhyay ,  Ashok Rattan

发明人： Biswajit Das ,  Mohammad Salman ,  Santosh Haribhau Kurhade ,  Ramadass Venkataramanan ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Rita Katoch ,  Anish Bandyopadhyay ,  Ashok Rattan

IPC分类号： A61K31/7028 ,  C07H17/08 ,  A61P31/04

CPC分类号： C07H17/00

摘要： The present invention provides ketolide derivatives, which can be used as anti-bacterial agents. Compounds disclosed herein can be used for the treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods of treating bacterial infections.

摘要翻译： 本发明提供可用作抗菌剂的酮内酯衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，更具体地针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫萨卡氏菌，衣原体属， 支原体属，军团菌属，分枝杆菌属，幽杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了用于制备本文公开的化合物的方法，其合成中使用的中间体，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US20090005325A1

公开(公告)日：2009-01-01

申请号：US12094839

申请日：2006-11-21

申请人： Biswajit Bas ,  Anjan Chakrabarti ,  Ramadass Venkataramanan ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Rita Katoch ,  Gobind Singh Kapkoti ,  Yogash Baban Surase ,  Mohammad Salman ,  Dilip J. Upadhyay

发明人： Biswajit Bas ,  Anjan Chakrabarti ,  Ramadass Venkataramanan ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Rita Katoch ,  Gobind Singh Kapkoti ,  Yogash Baban Surase ,  Mohammad Salman ,  Dilip J. Upadhyay

IPC分类号： A61K31/7048 ,  A61P31/12 ,  C07H17/08

CPC分类号： C07H17/08

摘要： Provided herein are ketolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae, Propionibacterium acnes or any combination thereof. Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.

摘要翻译： 本文提供了可用作抗菌剂的酮内酯衍生物。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌属，衣原体属，支原体 ，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属，痤疮丙酸杆菌或其任何组合。 还提供了制备本文所述的化合物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US20080287376A1

公开(公告)日：2008-11-20

申请号：US11572619

申请日：2005-07-28

申请人： Biswajit Das ,  Mohammad Salman ,  Atul Kashinath Hajare ,  Ramadass Venkataramanan ,  Rita Katoch ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Anjan Chakrabarti ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Yogesh Baban Surase ,  Ashok Rattan

发明人： Biswajit Das ,  Mohammad Salman ,  Atul Kashinath Hajare ,  Ramadass Venkataramanan ,  Rita Katoch ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Anjan Chakrabarti ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Yogesh Baban Surase ,  Ashok Rattan

IPC分类号： A61K31/7048 ,  C07H17/08 ,  A61P31/04

CPC分类号： C07H17/00

摘要： The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp. Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebaclerium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.

摘要翻译： 本发明提供可用作抗菌剂的酮内酯衍生物。 特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌。 衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。 还提供了制备这种酮内酯衍生物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US20080207536A1

公开(公告)日：2008-08-28

申请号：US11572754

申请日：2005-07-13

申请人： Biswajit Das ,  Rita Katoch ,  Atul Kashinath Hajare ,  Gobind Singh Kapkoti ,  Anish Bandyopadhyay ,  Ramadass Venkataramanan ,  Rajesh Kumar ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Anjan Chakrabarti ,  Yogesh Baban Surase ,  Mohammad Salman ,  Ashok Rattan

发明人： Biswajit Das ,  Rita Katoch ,  Atul Kashinath Hajare ,  Gobind Singh Kapkoti ,  Anish Bandyopadhyay ,  Ramadass Venkataramanan ,  Rajesh Kumar ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Anjan Chakrabarti ,  Yogesh Baban Surase ,  Mohammad Salman ,  Ashok Rattan

IPC分类号： A61K31/7048 ,  C07H17/08 ,  A61P31/04

CPC分类号： C07H17/08

摘要： The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for the treatment or prevention of a condition caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against bacterium such as Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Myobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Baccillus or Enterobactericeae. Processes for the preparation of disclosed compounds, pharmaceutical compositions thereof, and method of treating bacterial infections, are also provided.

摘要翻译： 本发明提供可用作抗菌剂的酰化物衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起的或由其贡献的病症，特别是针对细菌如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫萨拉氏菌，衣原体 肉豆蔻，军团菌属，Myobacterium，Helicobacter，Clostridium，拟杆菌属，棒状杆菌属，Baccillus或肠杆菌属。 还提供了制备所公开的化合物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US20090312344A1

公开(公告)日：2009-12-17

申请号：US11569838

申请日：2005-05-31

申请人： Mohammad Salman ,  Somesh Sharma ,  Gyan Chand Yadav ,  Gobind Singh Kapkoti ,  Anurag Mishra ,  Praful Gupta ,  Nitya Anand ,  Anita Chugh ,  Kamna Nanda

发明人： Mohammad Salman ,  Somesh Sharma ,  Gyan Chand Yadav ,  Gobind Singh Kapkoti ,  Anurag Mishra ,  Praful Gupta ,  Nitya Anand ,  Anita Chugh ,  Kamna Nanda

IPC分类号： A61K31/496 ,  C07D403/02 ,  A61P13/00 ,  C07D241/04

CPC分类号： C07D207/404 ,  C07D207/416 ,  C07D207/452 ,  C07D209/48 ,  C07D209/94 ,  C07D211/88 ,  C07D409/12 ,  C07D513/04

摘要： The present invention relates to α1, and/or α1d adrenergic receptor antagonists, which can function as α1a and/or α1d adrenergic receptor antagonist and can be used for the treatment of a disease or disorder mediated through α1a and/or an adrenergic receptor. Compounds disclosed herein can be used for the treatment of benign prostatic hyperplasia (BPH) and the related symptoms thereof. Further, compounds disclosed herein can be used for the treatment of lower urinary tract symptoms associated with or without BPH. Also provided are processes for preparing such compounds, pharmaceutical compositions thereof, and the methods of treating BPH or related symptoms thereof.

摘要翻译： 本发明涉及α1和/或α1肾上腺素能受体拮抗剂，其可用作α1a和/或α1肾上腺素能受体拮抗剂，并且可用于治疗通过α1a和/或肾上腺素能受体介导的疾病或病症。 本文公开的化合物可用于治疗良性前列腺增生（BPH）及其相关症状。 此外，本文公开的化合物可用于治疗与或不与BPH相关的下尿路症状。 还提供了制备这种化合物的方法，其药物组合物，以及治疗BPH或其相关症状的方法。