公开(公告)号：US20090005325A1

公开(公告)日：2009-01-01

申请号：US12094839

申请日：2006-11-21

申请人： Biswajit Bas ,  Anjan Chakrabarti ,  Ramadass Venkataramanan ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Rita Katoch ,  Gobind Singh Kapkoti ,  Yogash Baban Surase ,  Mohammad Salman ,  Dilip J. Upadhyay

发明人： Biswajit Bas ,  Anjan Chakrabarti ,  Ramadass Venkataramanan ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Rita Katoch ,  Gobind Singh Kapkoti ,  Yogash Baban Surase ,  Mohammad Salman ,  Dilip J. Upadhyay

IPC分类号： A61K31/7048 ,  A61P31/12 ,  C07H17/08

CPC分类号： C07H17/08

摘要： Provided herein are ketolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae, Propionibacterium acnes or any combination thereof. Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.

摘要翻译： 本文提供了可用作抗菌剂的酮内酯衍生物。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌属，衣原体属，支原体 ，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属，痤疮丙酸杆菌或其任何组合。 还提供了制备本文所述的化合物的方法，其药物组合物和治疗细菌感染的方法。