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    Methods of inducing or enhancing connective tissue repair
    3.
    发明授权
    Methods of inducing or enhancing connective tissue repair 有权
    诱导或增强结缔组织修复的方法

    公开(公告)号：US07504099B2

    公开(公告)日：2009-03-17

    申请号：US10330674

    申请日：2002-12-30

    申请人： Dan Gazit ,  Gadi Pelled ,  Gadi Turgeman ,  Andrea Hoffmann ,  Peter Eberle ,  Gerhard Gross

    发明人： Dan Gazit ,  Gadi Pelled ,  Gadi Turgeman ,  Andrea Hoffmann ,  Peter Eberle ,  Gerhard Gross

    IPC分类号： A61K48/00 ,  A01N63/00 ,  A01N43/04

    CPC分类号： C12N5/0663 ,  A61K35/12 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702 ,  C12N2510/02

    摘要： This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of connective tissue as a result of a defect, injury or condition of the connective tissue of a subject comprising the step of inserting an engineered cell which comprises a nucleic acid encoding a SMAD protein or variant thereof, so as to induce regeneration, repair and/or development of the connective tissue. This invention further provides methods of ex-vivo implantation of engineered cells into an injury, defect or condition of the connective tissue. This invention also provides a nucleic acid encoding a SMAD 8 protein variant, cells comprising such SMAD 8 variant, include mesenchymal stem cells, progenitor cells or cells derived from a connective tissue. Lastly, this invention provides SMAD 8 protein variant.

    摘要翻译： 本发明提供了修复，再生，治疗或诱导修复受试者的结缔组织的损伤，缺陷或病症的方法。 本发明提供了由于受试者的结缔组织的缺陷，损伤或病症导致的结缔组织的再生，增强，诱导修复和/或发育的方法，所述方法包括插入工程化细胞的步骤，所述工程细胞包含编码 SMAD蛋白或其变体，以诱导结缔组织的再生，修复和/或发育。 本发明还提供将工程化细胞离体植入结缔组织的损伤，缺陷或状况的方法。 本发明还提供编码SMAD 8蛋白质变体的核酸，包含这种SMAD8变体的细胞包括间充质干细胞，祖细胞或源自结缔组织的细胞。 最后，本发明提供了SMAD 8蛋白质变体。

    Slide bearing
    5.
    发明申请
    Slide bearing 审中-公开
    滑动轴承

    公开(公告)号：US20070140609A1

    公开(公告)日：2007-06-21

    申请号：US10593022

    申请日：2005-02-03

    申请人： Gerhard Gross ,  Martin Huber

    发明人： Gerhard Gross ,  Martin Huber

    IPC分类号： F16C33/02

    CPC分类号： F16C23/04 ,  F16C33/104 ,  F16C33/109 ,  F16C2380/26

    摘要： A sintered slide bearing for a shaft of an electrical machine has a bore for the shaft and also has capillary gaps. It is saturated with a lubricant. The surface region of the bore has zones of different density, which are saturated with a low-viscosity poly-alpha-olefin lubricant. As a result, positive values are established for the long-term performance and cold noises in an arbitrary installed position.

    摘要翻译： 用于电机轴的烧结滑动轴承具有用于轴的孔，并且还具有毛细管间隙。 用润滑剂饱和。 孔的表面区域具有不同密度的区域，其被低粘度聚-α-烯烃润滑剂饱和。 因此，为任意安装位置的长期性能和冷噪声建立正值。

    System and method for determining segment and link bandwidth capacities
    7.
    发明申请
    System and method for determining segment and link bandwidth capacities 审中-公开

    公开(公告)号：US20060120300A1

    公开(公告)日：2006-06-08

    申请号：US11338020

    申请日：2006-01-24

    申请人： Gerhard Gross

    发明人： Gerhard Gross

    IPC分类号： H04J1/16

    CPC分类号： H04L41/0896 ,  H04L43/50

    摘要： A method for determining bandwidth capacity of a test segment by sending one or more short packet bursts or streams from unique source smart nodes (SNs) over a link, which has the test segment, to one or more destination SNs. Selected source SNs send packet bursts or streams to other selected SNs at precise times so that the packet bursts or streams traverse the test segment simultaneously. Analyses of the traffic flow patterns at the destination SNs, including byte count measurements and time stamps, are used to determine the bandwidth capacity of the test segment.

    Methods and compositions for enhancing cartilage repair
    8.
    发明申请
    Methods and compositions for enhancing cartilage repair 审中-公开
    增强软骨修复的方法和组合

    公开(公告)号：US20060069053A1

    公开(公告)日：2006-03-30

    申请号：US11223856

    申请日：2005-09-12

    申请人： Dan Gazit ,  Yoram Zilberman ,  Gadi Turgeman ,  Gadi Pelled ,  Gerhard Gross ,  Andrea Hoffmann

    发明人： Dan Gazit ,  Yoram Zilberman ,  Gadi Turgeman ,  Gadi Pelled ,  Gerhard Gross ,  Andrea Hoffmann

    IPC分类号： A61K48/00

    CPC分类号： C12N5/0655 ,  A61K35/12 ,  C12N2510/00

    摘要： The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell, which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector, which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition-comprising cell that expresses a factor of the T-box family, which includes inter-alia the brachyury.

    摘要翻译： 本发明涉及增强软骨修复和/或诱导软骨形成的方法，该方法是通过施用表达T盒家族的因子的细胞，所述细胞尤其包括brachyury。 在另一个实施方案中，本发明涉及工程改造的细胞，其用包含编码T盒家族因子的核酸序列的载体转染，从而表达T盒家族的因子。 在另一个实施方案中，本发明涉及包含载体的组合物，其包含编码T盒家族因子的核酸序列，在另一个实施方案中，包含表达T盒家族因子的组合物包含细胞，其包括 特别是brachyury。

    Process to improve the performance of the exothermic incineration of waste material
    9.
    发明授权
    Process to improve the performance of the exothermic incineration of waste material 有权
    提高废料放热焚烧性能的工艺

    公开(公告)号：US06832566B2

    公开(公告)日：2004-12-21

    申请号：US10290589

    申请日：2002-11-08

    申请人： Gerhard Gross ,  Otto Lailach

    发明人： Gerhard Gross ,  Otto Lailach

    IPC分类号： F23G500

    CPC分类号： F23G5/085 ,  F23G2201/701 ,  F23G2201/90 ,  F23L7/002 ,  F23L7/007 ,  Y02E20/344

    摘要： The starting point is a process to improve the performance of the incineration of combustible waste material in an incineration chamber, whereby the waste material is conveyed to a burner flame where it is burned with combustion air at a temperature in the range from 1100° C. to 1700° C. [2012° F. to 3092° F.]. On this basis, in order to create a process that allows a capacity increase of installations employed for the exothermal incineration of waste materials, it is proposed according to the invention that at least part of the combustion air is replaced by an oxygen-rich gas having an oxygen content that is higher than that of air and that the oxygen-rich gas is mixed with a cooling medium.

    摘要翻译： 起点是提高焚烧室中可燃废料焚烧性能的过程，由此将废料输送到燃烧器火焰，在其中燃烧空气在1100℃的温度下燃烧。 至1700°C [2012°F至3092°F]。 在此基础上，为了创建允许废弃物放热焚烧所用设备的容量增加的过程，根据本发明提出，至少部分燃烧空气被富氧气体代替，所述富氧气体具有 氧含量高于空气，并且富氧气体与冷却介质混合。