公开(公告)号：US20250002943A1

公开(公告)日：2025-01-02

申请号：US18695454

申请日：2022-09-29

Applicant: Genome Research Limited

Inventor： Andrew BASSETT ,  Valentina MIGLIORI ,  Thomas BURGOLD

IPC: C12N15/90 ,  C12N9/22 ,  C12N15/11

Abstract: A single step method for gene editing using single-stranded oligo DNA nucleotide (ssODN) homology-directed repair (HDR) and a DNA recombinase is described. Systems, compositions and kits for one step gene editing are also described.

公开(公告)号：US12178864B2

公开(公告)日：2024-12-31

申请号：US17420993

申请日：2020-01-07

Applicant: GENOME RESEARCH LIMITED (GB/GB)

Inventor： Gavin Wright ,  Delphine Autheman

IPC: A61K39/005 ,  A61P33/02 ,  A61K39/00

Abstract: The invention relates to a trypanosomalvaccine, to pharmaceutical compositions comprising said vaccine and to their uses in vaccination to prevent trypanosomal infection in a mammal.

公开(公告)号：US20240309457A1

公开(公告)日：2024-09-19

申请号：US18273715

申请日：2022-01-21

Applicant: THE BROAD INSTITUTE, INC. ,  MEMORIAL SLOAN-KETTERING CANCER CENTER ,  SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH ,  MEMORIAL HOSPITAL FOR THE TREATMENT OF CANCER AND ALLIED DISEASES ,  GENOME RESEARCH LIMITED

Inventor： Mia Petljak ,  Michael R. Stratton ,  John Maciejowski

IPC: C12Q1/6886 ,  C07K16/40 ,  C12N5/09 ,  C12N15/113 ,  G01N33/50

CPC classification number: C12Q1/6886 ,  C07K16/40 ,  C12N5/0693 ,  C12N15/1137 ,  G01N33/5011 ,  C12N2310/14 ,  C12N2510/00 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The present disclosure provides methods for treating cancer in a subject (by inhibiting e.g., APOBEC3A, APOBEC3B, or REV1), and methods of diagnosing cancer in a subject. Methods of tracking mutagenesis induced by a gene of interest (e.g., APOBEC3A, APOBEC3B, or REV1) and methods of screening for inhibitors and synthetic lethalities are also described herein. Further provided by the present disclosure are cell lines and antibodies for use in the methods described herein.

公开(公告)号：US12090196B2

公开(公告)日：2024-09-17

申请号：US17420982

申请日：2020-01-07

Applicant: GENOME RESEARCH LIMITED (GB/GB)

Inventor： Gavin Wright ,  Delphine Autheman

IPC: A61K39/005 ,  A61P33/02

CPC classification number: A61K39/005 ,  A61P33/02

Abstract: The invention relates to a trypanosomal vaccine, to pharmaceutical compositions comprising said vaccine and to their uses in vaccination to prevent trypanosomal infection in a mammal.

公开(公告)号：US12062416B2

公开(公告)日：2024-08-13

申请号：US16096731

申请日：2017-04-28

Applicant: GENOME RESEARCH LIMITED

Inventor： Serena Nik-Zainal ,  Helen Davies ,  Dominik Glodzik ,  Sandro Morganella

IPC: G16B25/10 ,  C12Q1/6809 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B20/40 ,  G16B40/30

CPC classification number: G16B25/10 ,  C12Q1/6809 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B20/40 ,  G16B40/30 ,  C12Q1/6809 ,  C12Q2535/122 ,  C12Q2537/165

Abstract: The present invention provides methods of characterising a DNA sample obtained from a tumour to produce an interpreted profile of the tumour based on a combination of a range of tests on the tumour, the tests including a selection from: determining a catalogue of base substitution signatures which are present in the sample; determining a catalogue of rearrangement signatures which are present in the sample; determining a catalogue of insertion/deletion signatures which are present in the sample; determining the overall copy number profile in the sample and identifying putative driver mutations present in the sample.

公开(公告)号：US11512346B2

公开(公告)日：2022-11-29

申请号：US17435687

申请日：2020-02-27

Applicant: GENOME RESEARCH LIMITED

Inventor： Robert Osborne

IPC: C12Q1/6869

Abstract: Described herein is a method of sequencing a template that comprises a direct repeat, comprising: (a) in the same reaction, hybridizing a primer to a first site that is upstream of the first repeat sequence and hybridizing a primer to a second site that is upstream of the second repeat sequence, wherein the first and second sites are: (i) upstream of the first and second repeat sequences, respectively, and (ii) equidistant from the first and second repeat sequences; and (b) subjecting the hybridization product of (a) to a sequencing-by-synthesis sequencing reaction to produce a sequence read that comprises a combination of the first and second repeat sequences.

公开(公告)号：US20220184149A1

公开(公告)日：2022-06-16

申请号：US16094856

申请日：2017-04-19

Applicant: Genome Research Limited

Inventor： Anne NEVILLE ,  Hilary BROWNE ,  Sam FORSTER ,  Trevor LAWLEY

IPC: A61K35/742 ,  A61P31/04 ,  A61P1/04 ,  A61P1/14 ,  A61P1/16 ,  A61P1/06 ,  A61K9/00

Abstract: The invention relates to therapeutic compositions comprising at least one isolated bacterium and a pharmaceutically acceptable excipient, as well as methods of preparing such therapeutic compositions. The therapeutic compositions find application in the treatment of dysbiosis, in particular dysbiosis of the gastrointestinal tract.

公开(公告)号：US20210230556A1

公开(公告)日：2021-07-29

申请号：US16925518

申请日：2020-07-10

Applicant: GENOME RESEARCH LIMITED

Inventor： Pentao LIU ,  David RYAN ,  Xuefei GAO ,  Wei WANG ,  Jian YANG

IPC: C12N5/074 ,  C12N5/0735 ,  A01K67/027 ,  C12N5/073

Abstract: A culture medium is provided which is capable of establishing expanded potential stem cell (EPSC) lines which resemble naive or ground state ES cells, but are also able to differentiate into placenta trophoblasts and the embryo proper. Methods are provided using the medium for the in vitro conversion and maintenance of cells, including pluripotent cells into EPSCs.

公开(公告)号：US20210220329A1

公开(公告)日：2021-07-22

申请号：US16967472

申请日：2019-02-08

Applicant: THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE ,  GENOME RESEARCH LIMITED ,  DANA FARBER CANCER INSTITUTE

Inventor： William Curtis Reinhold ,  Mathew Garnett ,  Vinodh Nalin Rajapakse ,  Yves Pommier ,  Augustin Luna

IPC: A61K31/404 ,  A61K31/4402 ,  A61K31/704 ,  A61K33/243 ,  A61K31/282 ,  A61K31/475 ,  A61K31/675 ,  A61K31/337 ,  A61K31/513 ,  A61K31/7068 ,  A61K31/52 ,  A61K31/131 ,  A61P35/00 ,  A61N5/10

Abstract: The disclosure provides a method of treating triple negative breast cancer in a patient, comprising administering a therapeutically effective amount of a compound selected from oxyphenisatin, oxyphenisatin acetate, and bisacodyl, or the pharmaceutically acceptable salts or hydrates of any of the foregoing to the patient. The disclosure also provides methods of using oxyphenisatin or bisacodyl, or a salt or hydrate thereof, as a first active agent in combination with one or more additional active agents to treat triple negative breast cancer. The disclosure further provides methods for determining whether a patient suffering from triple negative breast cancer would be responsive to treatment with oxyphenisatin or bisacodyl.

公开(公告)号：US20200056202A1

公开(公告)日：2020-02-20

申请号：US16604120

申请日：2018-04-10

Applicant: GENOME RESEARCH LIMITED

Inventor： Jolyon Nicolas Edouard MARTIN ,  Allan BRADLEY

IPC: C12N15/85 ,  A01K67/027 ,  C07K16/46 ,  C12N5/0781

Abstract: The present invention relates inter alia to a rodent or rodent cell having a genome comprising: i) one or more companion animal IGH V region genes, one or more companion animal D region genes and one or more companion animal J region genes; and (ii) optionally one or more companion animal IGL kappa V region genes and one or more companion animal IGL kappa J region genes; and/or one or more companion animal IGL lambda V region genes and one or more companion animal IGL lambda J region genes, wherein the rodent or rodent cell is capable of expressing the companion animal variable region gene(s) to form an antibody chain and wherein the companion animal species is not a rodent.