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公开(公告)号：US08183350B2
公开(公告)日：2012-05-22
申请号：US10513573
申请日：2003-05-05
Applicant: Elliott A. Gruskin , Jennifer F. Iaci , Andrea M. Vecchione , Sarah J. Kasperbauer , Gargi Roy
Inventor： Elliott A. Gruskin , Jennifer F. Iaci , Andrea M. Vecchione , Sarah J. Kasperbauer , Gargi Roy
IPC: A61K38/48 , A61K31/726 , A61K31/737
CPC classification number: A61K38/51 , C12N9/88 , C12Y402/02005 , C12Y402/02019
Abstract: Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration.
Abstract translation: 通过施用软骨素酶AC和/或软骨素酶B来降解抑制或有助于抑制神经组织再生的硫酸软骨素蛋白聚糖来实现中枢神经系统中的神经生长。
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公开(公告)号：US07429375B2
公开(公告)日：2008-09-30
申请号：US10848561
申请日：2004-05-17
Applicant: Elliott A. Gruskin , Rohini D'Souza , Gargi Roy , Anthony O. Caggiano
Inventor： Elliott A. Gruskin , Rohini D'Souza , Gargi Roy , Anthony O. Caggiano
CPC classification number: C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
Abstract: The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.
Abstract translation: 本公开涉及软骨素酶蛋白的制备和缺失突变体及其在促进治疗组合物扩散到组织中的方法及其在中枢神经系统（“CNS”）损伤或疾病之后神经功能恢复的用途。
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公开(公告)号：US20070274979A1
公开(公告)日：2007-11-29
申请号：US10513573
申请日：2003-05-05
Applicant: Elliott Gruskin , Jennifer Iaci , A.M. Vecchione , Sarah Kasperbauer , Gargi Roy
Inventor： Elliott Gruskin , Jennifer Iaci , A.M. Vecchione , Sarah Kasperbauer , Gargi Roy
CPC classification number: A61K38/51 , C12N9/88 , C12Y402/02005 , C12Y402/02019
Abstract: Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration.
Abstract translation: 通过施用软骨素酶AC和/或软骨素酶B来降解抑制或有助于抑制神经组织再生的硫酸软骨素蛋白聚糖来实现中枢神经系统中的神经生长。
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公开(公告)号：US08785606B2
公开(公告)日：2014-07-22
申请号：US13451968
申请日：2012-04-20
Applicant: Elliott A. Gruskin , Jennifer F. Iaci , Andrea M. Vecchione , Sarah J. Kasperbauer , Gargi Roy
Inventor： Elliott A. Gruskin , Jennifer F. Iaci , Andrea M. Vecchione , Sarah J. Kasperbauer , Gargi Roy
IPC: A61K38/48 , A61K31/726 , A61K31/737
CPC classification number: A61K38/51 , C12N9/88 , C12Y402/02005 , C12Y402/02019
Abstract: Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration.
Abstract translation: 通过施用软骨素酶AC和/或软骨素酶B来降解抑制或有助于抑制神经组织再生的硫酸软骨素蛋白聚糖来实现中枢神经系统中的神经生长。
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公开(公告)号：US20090028829A1
公开(公告)日：2009-01-29
申请号：US10848564
申请日：2004-05-17
Applicant: Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Jennifer Iaci , Michael P. Zimber
Inventor： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Jennifer Iaci , Michael P. Zimber
CPC classification number: C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
Abstract: This disclosure relates to compositions capable of use in the treatment of spinal cord injuries and related disorders of the central nervous system (CNS), and in particular, compositions including proteoglycan degrading molecules and compositions capable of blocking and/or over coming the activity of neuronal growth inhibitory molecules, as well as fusion proteins which includes a proteoglycan degrading domain and a domain capable of blocking and or over coming the activity of neuronal growth inhibitory molecules.
Abstract translation: 本公开涉及能够用于治疗脊髓损伤和中枢神经系统（CNS）的相关病症的组合物，特别是包括蛋白多糖降解分子和能够阻断和/或超过神经元活性的组合物的组合物 生长抑制分子，以及融合蛋白，其包括蛋白聚糖降解结构域和能够阻断和或超过神经元生长抑制分子活性的结构域。
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Patent Agency Ranking
公开(公告)号：US20060233782A1
公开(公告)日：2006-10-19
申请号：US10848561
申请日：2004-05-17
Applicant: Elliott Gruskin , Rohini D'Souza , Gargi Roy , Anthony Caggiano
Inventor： Elliott Gruskin , Rohini D'Souza , Gargi Roy , Anthony Caggiano
CPC classification number: C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
Abstract: The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.
Abstract translation: 本公开涉及软骨素酶蛋白的制备和缺失突变体及其在促进治疗组合物扩散到组织中的方法及其在中枢神经系统（“CNS”）损伤或疾病之后神经功能恢复的用途。
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公开(公告)号：US07968089B2
公开(公告)日：2011-06-28
申请号：US12167573
申请日：2008-07-03
Applicant: Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Rohini D'Souza
Inventor： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Rohini D'Souza
CPC classification number: C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
Abstract: The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.
Abstract translation: 本公开涉及软骨素酶蛋白的制备和缺失突变体及其在促进治疗组合物扩散到组织中的方法及其在中枢神经系统（“CNS”）损伤或疾病之后神经功能恢复的用途。
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公开(公告)号：US20090041728A1
公开(公告)日：2009-02-12
申请号：US12167573
申请日：2008-07-03
Applicant: Elliott A. Gruskin , Rohini D'Souza , Gargi Roy , Anthony O. Caggiano
Inventor： Elliott A. Gruskin , Rohini D'Souza , Gargi Roy , Anthony O. Caggiano
CPC classification number: C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
Abstract: The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.
Abstract translation: 本公开涉及软骨素酶蛋白的制备和缺失突变体及其在促进治疗组合物扩散到组织中的方法及其在中枢神经系统（“CNS”）损伤或疾病之后神经功能恢复的用途。
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公开(公告)号：US20110250631A1
公开(公告)日：2011-10-13
申请号：US13112985
申请日：2011-05-20
Applicant: Elliott A. GRUSKIN , Rohini D'SOUZA , Gargi ROY , Anthony G. Caggiano
Inventor： Elliott A. GRUSKIN , Rohini D'SOUZA , Gargi ROY , Anthony G. Caggiano
CPC classification number: C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
Abstract: The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.
Abstract translation: 本公开涉及软骨素酶蛋白的制备和缺失突变体及其在促进治疗组合物扩散到组织中的方法及其在中枢神经系统（“CNS”）损伤或疾病之后神经功能恢复的用途。
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公开(公告)号：US08906363B2
公开(公告)日：2014-12-09
申请号：US10848564
申请日：2004-05-17
Applicant: Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Jennifer Iaci , Michael P. Zimber
Inventor： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Jennifer Iaci , Michael P. Zimber
CPC classification number: C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
Abstract: This disclosure relates to compositions capable of use in the treatment of spinal cord injuries and related disorders of the central nervous system (CNS), and in particular, compositions including proteoglycan degrading molecules and compositions capable of blocking and/or over coming the activity of neuronal growth inhibitory molecules, as well as fusion proteins which includes a proteoglycan degrading domain and a domain capable of blocking and or over coming the activity of neuronal growth inhibitory molecules.
Abstract translation: 本公开涉及能够用于治疗脊髓损伤和中枢神经系统（CNS）的相关病症的组合物，特别是包括蛋白多糖降解分子和能够阻断和/或超过神经元活性的组合物的组合物 生长抑制分子，以及融合蛋白，其包括蛋白聚糖降解结构域和能够阻断和或超过神经元生长抑制分子活性的结构域。
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