公开(公告)号：US08183350B2

公开(公告)日：2012-05-22

申请号：US10513573

申请日：2003-05-05

Applicant: Elliott A. Gruskin ,  Jennifer F. Iaci ,  Andrea M. Vecchione ,  Sarah J. Kasperbauer ,  Gargi Roy

Inventor： Elliott A. Gruskin ,  Jennifer F. Iaci ,  Andrea M. Vecchione ,  Sarah J. Kasperbauer ,  Gargi Roy

IPC: A61K38/48 ,  A61K31/726 ,  A61K31/737

CPC classification number: A61K38/51 ,  C12N9/88 ,  C12Y402/02005 ,  C12Y402/02019

Abstract: Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration.

Abstract translation: 通过施用软骨素酶AC和/或软骨素酶B来降解抑制或有助于抑制神经组织再生的硫酸软骨素蛋白聚糖来实现中枢神经系统中的神经生长。

公开(公告)号：US08785606B2

公开(公告)日：2014-07-22

申请号：US13451968

申请日：2012-04-20

Applicant: Elliott A. Gruskin ,  Jennifer F. Iaci ,  Andrea M. Vecchione ,  Sarah J. Kasperbauer ,  Gargi Roy

Inventor： Elliott A. Gruskin ,  Jennifer F. Iaci ,  Andrea M. Vecchione ,  Sarah J. Kasperbauer ,  Gargi Roy

IPC: A61K38/48 ,  A61K31/726 ,  A61K31/737

CPC classification number: A61K38/51 ,  C12N9/88 ,  C12Y402/02005 ,  C12Y402/02019

Abstract: Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration.

Abstract translation: 通过施用软骨素酶AC和/或软骨素酶B来降解抑制或有助于抑制神经组织再生的硫酸软骨素蛋白聚糖来实现中枢神经系统中的神经生长。