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1.发明授权Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease 失效波形蛋白定向诊断和治疗多药耐药性肿瘤疾病公开(公告)号：US07550256B2
公开(公告)日：2009-06-23
申请号：US10736889
申请日：2003-12-15
Applicant: Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
Inventor： Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
IPC: G01N33/574 , G01N33/53
CPC classification number: G01N33/574 , G01N33/6893 , G01N2800/44 , G01N2800/52
Abstract: Disclosed are methods for detecting multidrug resistance in neoplastic or damaged cells or multidrug resistant (MDR) neoplastic or damaged cells by detecting an increase in the cell surface expression of vimentin protein in such cells as compared to the level of cell surface expression of vimentin protein in a normal cell or a non-MDR neoplastic cell.
Abstract translation: 公开的是通过检测这种细胞中波形蛋白蛋白的细胞表面表达的增加与波形蛋白的细胞表面表达水平相比，检测肿瘤或受损细胞或多药耐药（MDR）肿瘤或损伤细胞中的多药耐药性的方法 正常细胞或非MDR肿瘤细胞。
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Patent Agency Ranking
2.发明授权Nucleophosmin directed diagnostics and therapeutics for multidrug resistant neoplastic disease 失效Nucleophosmin定向诊断和治疗多药耐药性肿瘤疾病公开(公告)号：US07413851B2
公开(公告)日：2008-08-19
申请号：US10737712
申请日：2003-12-15
Applicant: Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
Inventor： Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
IPC: C12Q1/00
CPC classification number: G01N33/57492 , A61K39/0005 , A61K39/0011 , G01N33/5005 , G01N33/574 , G01N33/6875 , G01N2800/52
Abstract: Disclosed are methods for detecting neoplastic or damaged cells and for detecting multidrug resistance in neoplastic or damaged cells by detecting an increase in the cell surface expression of a nucleophosmin (NPM) protein on the surface of such a multidrug resistant neoplastic or damaged cells as compared to the level of expression of the nucleophosmin protein on the surface of a normal cell.
Abstract translation: 公开了通过检测这种多药耐药肿瘤或受损细胞的表面上的核磷酸（NPM）蛋白的细胞表面表达的增加来检测肿瘤或损伤的细胞并检测肿瘤或受损细胞中的多药耐药性的方法， 正常细胞表面的核磷蛋白表达水平。
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3.发明授权HSC70 directed diagnostics and therapeutics for multidrug resistant neoplastic disease 失效HSC70定向诊断和治疗多药耐药肿瘤疾病公开(公告)号：US07226748B2
公开(公告)日：2007-06-05
申请号：US10737350
申请日：2003-12-15
Applicant: Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
Inventor： Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
IPC: G01N33/53
CPC classification number: G01N33/57492 , A61K47/51 , G01N33/5011 , G01N2800/44 , G01N2800/52
Abstract: Disclosed are methods for detecting neoplastic or damaged cells and for detecting multidrug resistance in neoplastic or damaged cells by detecting an increase in the cell surface expression of a heat shock cognate (HSC70) protein 70 on the surface of such a multidrug resistant neoplastic or damaged cells as compared to the level of expression of the HSC70 protein on the surface of a normal cell.
Abstract translation: 公开了通过检测这种多重耐药性肿瘤或损伤细胞表面的热休克同源（HSC70）蛋白70的细胞表面表达增加来检测肿瘤或损伤细胞并检测肿瘤或受损细胞中的多药耐药性的方法 与正常细胞表面的HSC70蛋白的表达水平相比。
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4.发明授权公开(公告)号：US07358042B2
公开(公告)日：2008-04-15
申请号：US10801988
申请日：2004-03-15
Applicant: Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
Inventor： Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
IPC: C12Q1/00 , G01N33/53 , A61K39/395 , C07K16/30
CPC classification number: G01N33/57496 , G01N33/5017 , G01N2333/99 , G01N2800/44 , G01N2800/52
Abstract: Disclosed are methods for detecting neoplastic or damaged cells and for detecting multidrug resistance in neoplastic or damaged cells by detecting an increase in the cellular expression of a triosephosphate isomerase (TPI) protein in a multidrug resistant neoplastic or damaged cells as compared to the level of expression of the triosephosphate isomerase protein in a normal cell.
Abstract translation: 公开了通过检测多药耐药肿瘤或损伤的细胞中的磷酸三磷酸异构酶（TPI）蛋白的细胞表达的增加而与肿瘤或受损细胞的表达水平相比，检测肿瘤或损伤的细胞和检测肿瘤或受损细胞的多药耐药性的方法 的三磷酸异构酶蛋白。
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5.发明申请Vimentin Directed Diagnostics And Therapeutics For Multidrug Resistant Neoplastic Disease 审中-公开波形蛋白导向诊断和治疗多药耐药性疾病公开(公告)号：US20100260667A1
公开(公告)日：2010-10-14
申请号：US12260892
申请日：2008-10-29
Applicant: Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
Inventor： Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
IPC: A61K39/395 , G01N33/574 , C12Q1/68 , C07H21/04 , A61K9/127 , A61K51/10 , A61K39/00 , A61P35/00
CPC classification number: A61K51/1045 , A61K45/06 , A61K47/6823 , A61K47/6851 , G01N2800/44
Abstract: Disclosed are methods for detecting multidrug resistance in neoplastic or damaged cells or multidrug resistant (MDR) neoplastic or damaged cells by detecting an increase in the cell surface expression of vimentin protein in such cells as compared to the level of cell surface expression of vimentin protein in a normal cell or a non-MDR neoplastic cell.
Abstract translation: 公开的是通过检测这种细胞中波形蛋白蛋白的细胞表面表达的增加与波形蛋白的细胞表面表达水平相比，检测肿瘤或受损细胞或多药耐药（MDR）肿瘤或损伤细胞中的多药耐药性的方法 正常细胞或非MDR肿瘤细胞。
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6.发明授权Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease 失效波形蛋白定向诊断和治疗多药耐药性肿瘤疾病公开(公告)号：US07670604B2
公开(公告)日：2010-03-02
申请号：US11173672
申请日：2005-07-01
Applicant: Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
Inventor： Elias Georges , Lucile Serfass , Anne-Marie Bonneau , Frédéric Dallaire
IPC: A61K39/395 , A61K39/00
CPC classification number: A61K51/1045 , A61K45/06 , A61K47/6823 , A61K47/6851 , G01N2800/44
Abstract: Disclosed are methods for treating or preventing a neoplastic or a multidrug resistant neoplasm in a subject using cell surface vimentin targeted therapeutic agents.
Abstract translation: 公开了使用细胞表面波形蛋白靶向治疗剂治疗或预防受试者的肿瘤或多药耐药性肿瘤的方法。
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