公开(公告)号：US5270139A

公开(公告)日：1993-12-14

申请号：US908174

申请日：1992-07-02

Applicant: Feng-Wen Yeng ,  Jia-Ming Liu

Inventor： Feng-Wen Yeng ,  Jia-Ming Liu

IPC: C09B35/34 ,  C09B67/22 ,  G03G5/06 ,  G03G5/047

CPC classification number: C09B35/34 ,  C09B67/0041 ,  G03G5/0611 ,  G03G5/0618 ,  G03G5/0681

Abstract: A new organophotoconductor comprising a conductive substrate, a charge generation layer and a charge transport layer wherein the charge generation layer comprises a bisazo compound and a squarylium compound as the charge generation material. The organophotoconductor exhibits high sensitivity, low residual potential and improved durability and reproducibility.

Abstract translation: 一种新的有机光电导体，包括导电衬底，电荷产生层和电荷传输层，其中电荷产生层包含双偶氮化合物和方酸化合物作为电荷产生材料。 有机光电导体表现出高灵敏度，低残留电位和改善的耐久性和再现性。

公开(公告)号：US5504221A

公开(公告)日：1996-04-02

申请号：US397846

申请日：1995-03-02

Applicant: Feng-Wen Yeng ,  Jaw-Yuh Chiu ,  Chia-Lin J. Wang

Inventor： Feng-Wen Yeng ,  Jaw-Yuh Chiu ,  Chia-Lin J. Wang

IPC: C07D317/68 ,  C07D317/64

CPC classification number: C07D317/68

Abstract: A method for resolving racemic dimethyl-4,4'-dimethoxy-5,6,5',6'-di(methylenedioxy)biphenyl-2,2'-dicarboxylate ("DDB"), in which a chiral .alpha.-alkyl benzyl alcohol is used as the resolving agent. More specifically, racemic DDB is first hydrolyzed to form dicarboxylic acid, which is then reacted with chiral .alpha.-alkyl benzyl alcohol to form two chiral isomers. The chiral isomers, after separation either by chromatography or by recrystalli-zation, are respectively hydrogenated and esterified to form chiral DDB isomers.

Abstract translation: 一种拆分外消旋二甲基-4,4'-二甲氧基-5,6,5'，6'-二（亚甲二氧基）联苯-2,2'-二羧酸酯（“DDB”）的方法，其中手性α-烷基苄基 酒精用作拆分剂。 更具体地说，外消旋DDB首先水解形成二羧酸，然后与手性α-烷基苄醇反应形成两个手性异构体。 通过色谱法或通过重结晶分离后的手性异构体分别氢化和酯化形成手性DDB异构体。

公开(公告)号：US5840991A

公开(公告)日：1998-11-24

申请号：US932030

申请日：1997-09-17

Applicant: Feng-Wen Yeng ,  Shan-Shue Wang ,  Jaw-Yuh Chiu ,  Chin-Fen Lee ,  Chia-Lin J. Wang

Inventor： Feng-Wen Yeng ,  Shan-Shue Wang ,  Jaw-Yuh Chiu ,  Chin-Fen Lee ,  Chia-Lin J. Wang

IPC: A61K31/10 ,  A61P3/06 ,  A61P9/10 ,  C07C315/02 ,  C07C317/22 ,  C07C319/14 ,  C07C323/20 ,  C07L315/00 ,  A01N41/10

CPC classification number: C07C323/20 ,  C07C317/22

Abstract: The invention relates to novel compounds of formula (I) ##STR1## wherein R.sub.1 represents hydrogen, hydroxy or alkoxy; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be hydrogen or alkyl; and n is 0,1 or 2; and the pharmaceutically acceptable salts thereof. The invention also relates to the processes for preparing the compounds of formula (I), and the pharmaceutical compositions containing them, and their use as a low density lipoprotein peroxidation inhibitors, anti-atherosclerotic agents and/or antihyperlipidemic agents.

Abstract translation: 本发明涉及新的式（I）化合物，其中R 1表示氢，羟基或烷氧基; R2，R3，R4和R5可以是氢或烷基; n为0,1或2; 及其药学上可接受的盐。 本发明还涉及制备式（I）化合物的方法，以及含有它们的药物组合物及其作为低密度脂蛋白过氧化抑制剂，抗动脉粥样硬化剂和/或抗高血脂药物的用途。