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公开(公告)号：US09593108B2
公开(公告)日：2017-03-14
申请号：US13259283
申请日：2010-04-05
申请人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
发明人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/437 , A61K31/506 , A61P31/14 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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2.发明申请SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS 有权取代的吡啶和吡嗪衍生物及其在治疗病毒感染中的应用公开(公告)号：US20140242027A1
公开(公告)日：2014-08-28
申请号：US13579399
申请日：2011-02-18
申请人： Ashok Arasappan , F. George Njoroge , Cecil D. Kwong , Subramaniam Ananthan , Frank Bennett , Francisco Velazquez , Vinay Girijavallabhan , Yuhua Huang , Hollis S. Kezer , Joseph Maddry , Robert C. REynold , Abhijit Roychowdhury , Anita T. Fowler , John A. Secrist, III , Ling Tong , Seong Heon Kim , Malcolm MacCoss , Srikanth Venkatraman , vishal Verma
发明人： Ashok Arasappan , F. George Njoroge , Cecil D. Kwong , Subramaniam Ananthan , Frank Bennett , Francisco Velazquez , Vinay Girijavallabhan , Yuhua Huang , Hollis S. Kezer , Joseph Maddry , Robert C. REynold , Abhijit Roychowdhury , Anita T. Fowler , John A. Secrist, III , Ling Tong , Seong Heon Kim , Malcolm MacCoss , Srikanth Venkatraman , vishal Verma
IPC分类号： C07D513/04 , C07D417/04 , A61K45/06 , C07D417/14 , C07D491/048 , A61K31/506
CPC分类号： A61K31/506 , A61K45/06 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D491/048 , C07D513/04
摘要： The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要翻译： 本发明提供式（I）的化合物：所述化合物的互变异构体，异构体和酯，以及所述化合物的药学上可接受的盐，溶剂合物和前药，其中R，R 1，X，Y，Z，R 2， R3，R4，R5，R6，R7，R8，R9，R18，R19和n独立选择和如本文所定义。 还提供了包含这些化合物的组合物。 本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。
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3.发明申请5'-SUBSTITUTED NUCLEOSIDE ANALOGS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权5'-取代的核苷类似物及其用于治疗病毒性疾病的方法公开(公告)号：US20140221304A1
公开(公告)日：2014-08-07
申请号：US14232536
申请日：2012-07-10
IPC分类号： C07H19/06 , C07H19/16 , C07H19/20 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K31/7076 , A61K45/06 , C07H19/10 , A61K31/7068
CPC分类号： A61K31/7056 , A01N37/46 , A61K31/341 , A61K31/4196 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： The present invention relates to 5′-Substituted Nucleoside Analogs of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, Z, R1, R2, R3 and R3′ are as defined herein. The present invention also relates to compositions comprising at least one 5′-Substituted Nucleoside Analog, and methods of using the 5′-Substituted Nucleoside Analogs for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的5'-取代的核苷类似物及其药学上可接受的盐，其中B，X，Z，R 1，R 2，R 3和R 3'如本文所定义。 本发明还涉及包含至少一种5'-取代的核苷类似物的组合物，以及使用5'-取代的核苷类似物来治疗或预防患者HCV感染的方法。
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4.发明申请2'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权2'-取代的核苷衍生物及其用于治疗病毒性疾病的方法公开(公告)号：US20140154211A1
公开(公告)日：2014-06-05
申请号：US14111687
申请日：2012-04-11
申请人： Vinay Girijavallabhan , F. George Njoroge , Stephane Bogen , Vishal Verma , Frank Bennett , Angela Kereles , Ashok Arasappan , Dmitri Pissarnitski , Qun Dang , Ian Davies , David B. Olsen , Andrew Stamford , Joseph P. Vacca
发明人： Vinay Girijavallabhan , F. George Njoroge , Stephane Bogen , Vishal Verma , Frank Bennett , Angela Kereles , Ashok Arasappan , Dmitri Pissarnitski , Qun Dang , Ian Davies , David B. Olsen , Andrew Stamford , Joseph P. Vacca
IPC分类号： A61K31/7072 , A61K31/7068 , A61K45/06 , C07H17/02
CPC分类号： A61K31/7072 , A01N47/36 , A61K31/7042 , A61K31/7068 , A61K45/06 , A61P31/14 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/207 , C07H19/213 , A01N2300/00 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/76 , A01N43/82 , A01N43/84 , A01N43/90
摘要： The present invention relates to 2′-Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Substituted Nucleoside Derivative, and methods of using the 2′-Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的2'-取代的核苷衍生物及其药学上可接受的盐，其中A，B，X，R 1，R 2和R 3如本文所定义。 本发明还涉及包含至少一种2'-取代的核苷衍生物的组合物，以及使用2'-取代的核苷衍生物治疗或预防患者HCV感染的方法。
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5.发明授权Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections 有权乙烯基取代的吡啶和嘧啶衍生物及其在治疗病毒感染中的应用公开(公告)号：US08715638B2
公开(公告)日：2014-05-06
申请号：US13059199
申请日：2009-08-19
申请人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Jeremy Clark , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , John A. Secrist, III , Neng-Yang Shih
发明人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Jeremy Clark , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , John A. Secrist, III , Neng-Yang Shih
IPC分类号： A61K31/505 , A61K38/21 , A61K39/42 , C07D239/02
CPC分类号： C07D239/48
摘要： The present invention provides compounds of Formula (A): (Chemical formula should be inserted here as it appears on abstract in paper form) (A) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, R22, R23, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要翻译： 本发明提供了式（A）化合物：（化学式应该插在这里，它以纸质形式的摘要出现）（A）和所述化合物的互变异构体，异构体和酯以及药学上可接受的盐，溶剂合物和前药 的所述化合物，其中R，R1，X，Y，Z，R2，R3，R4，R5，R6，R7，R8，R9，R18，R19，R22，R23和n各自独立地和定义 这里。 还提供了包含这些化合物的组合物。 本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。
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6.发明授权Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections 有权乙炔基取代的吡啶和嘧啶衍生物及其在治疗病毒感染中的应用公开(公告)号：US08541434B2
公开(公告)日：2013-09-24
申请号：US13059195
申请日：2009-08-19
申请人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Ashok Arasappan , Frank Bennett , Jeremy Clark , Anita T. Fowler , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , John A. Secrist, III , Neng-Yang Shih
发明人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Ashok Arasappan , Frank Bennett , Jeremy Clark , Anita T. Fowler , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , John A. Secrist, III , Neng-Yang Shih
IPC分类号： A61K31/506 , C07D239/24
CPC分类号： C07D239/46 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and pro-drugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要翻译： 本发明提供式（I）的化合物：所述化合物的互变异构体，异构体和酯，以及所述化合物的药学上可接受的盐，溶剂合物和前体药物，其中R，R 1，X，Y，Z， R2，R3，R4，R5，R6，R7，R8，R9，R18，R19和n独立选择和如本文所定义。 还提供了包含这些化合物的组合物。 本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。
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7.发明申请FUSED TRICYCLIC COMPOUNDS AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES 审中-公开用于治疗病毒性疾病的融合三聚体化合物及其衍生物公开(公告)号：US20120276047A1
公开(公告)日：2012-11-01
申请号：US13512073
申请日：2010-11-23
IPC分类号： A61K31/437 , C07D471/14 , C07D491/048 , C07D495/04 , A61K31/4188 , C07D513/04 , A61K31/429 , C07D498/04 , A61K31/424 , A61K31/4184 , A61P31/12 , A61P37/02 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K38/21 , C07D471/04
CPC分类号： C07D471/04 , C07D471/14 , C07D493/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to novel fused tricyclic compounds, compositions comprising at least one fused tricyclic compound, and methods of using fused tricyclic compounds for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及新的稠合三环化合物，包含至少一种稠合三环化合物的组合物，以及使用稠合三环化合物治疗或预防患者病毒感染或病毒相关病症的方法。
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8.发明申请ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF BETA-AMINO-ALPHA- HYDROXY AMIDES 有权氨基 - 氨基 - 羟丙基氨基酸的纯化和立体特异性合成公开(公告)号：US20120178942A1
公开(公告)日：2012-07-12
申请号：US13387619
申请日：2010-07-27
申请人： John Traverse , William M. Leong , Steven P. Miller , Jennifer Albaneze-Walker , Thomas J. Hunter , Lijun Wang , Hongbiao Liao , Ashok Arasappan , Scott T. Trzaska , Randi M. Smith , Azzeddine Lekhal , Stephane L. Bogen , Jianshe Kong , Frank Bennett , F. George Njoroge , Marc Poirier , Shen-Chun Kuo , Yonggang Chen , Kenneth S. Matthews , Patrice Demonchaux , Amadeo Ferreira
发明人： John Traverse , William M. Leong , Steven P. Miller , Jennifer Albaneze-Walker , Thomas J. Hunter , Lijun Wang , Hongbiao Liao , Ashok Arasappan , Scott T. Trzaska , Randi M. Smith , Azzeddine Lekhal , Stephane L. Bogen , Jianshe Kong , Frank Bennett , F. George Njoroge , Marc Poirier , Shen-Chun Kuo , Yonggang Chen , Kenneth S. Matthews , Patrice Demonchaux , Amadeo Ferreira
IPC分类号： C07D209/52 , C07C237/14 , C07C317/44 , C07C315/02 , C07C271/56 , C07C231/02 , C07C263/00 , C07C265/10 , C07C313/12 , C07C211/35 , C07C275/26 , C07C273/18
CPC分类号： C07D209/52 , C07C51/353 , C07C67/04 , C07C237/04 , C07C315/02 , C07C315/04 , C07C317/28 , C07C319/14 , C07C319/20 , C07C2601/02 , C07C2601/14 , C07K5/0202 , C07K5/06034 , C07C323/53 , C07C317/44 , C07C57/03 , C07C69/533
摘要： Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.
摘要翻译： 用于制备式I化合物的方法：式（I）。 公开了可用于制备式I化合物的中间体和用于制备所述中间体的方法。
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9.发明申请ETHYNYL-SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS 有权乙酰取代的吡啶和吡嗪衍生物及其在治疗病毒感染中的应用公开(公告)号：US20120107271A1
公开(公告)日：2012-05-03
申请号：US13059195
申请日：2009-08-19
申请人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Ashok Arasappan , Frank Bennett , Jeremy Clark , Anita T. Fowler , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , John A. Secrist, III , Neng-Yang Shih
发明人： Cecil D. Kwong , F. George Njoroge , Subramaniam Ananthan , Ashok Arasappan , Frank Bennett , Jeremy Clark , Anita T. Fowler , Feng Geng , Hollis S. Kezar, III , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , John A. Secrist, III , Neng-Yang Shih
IPC分类号： A61K31/506 , C07D409/06 , C07D405/06 , C07D403/06 , C07D239/49 , C07D409/14 , C07D417/06 , C07D417/14 , C07D413/14 , C07D405/14 , A61K38/21 , A61K31/7088 , A61K39/29 , A61K39/42 , A61P37/04 , A61P31/14 , C07D401/06
CPC分类号： C07D239/46 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and pro-drugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要翻译： 本发明提供式（I）的化合物：（化学式应该插入在此，其以纸的形式出现）（I）和所述化合物的互变异构体，异构体和酯以及药学上可接受的盐，溶剂合物和亲 所述化合物的药物，其中R，R 1，X，Y，Z，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 18，R 19和n各自独立地并如本文所定义。 还提供了包含这些化合物的组合物。 本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。
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10.发明授权Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease 有权硫化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US07816326B2
公开(公告)日：2010-10-19
申请号：US11733479
申请日：2007-04-10
申请人： Francisco Velazquez , Stephane L. Bogen , Ashok Arasappan , Srikanth Venkatraman , F. George Njoroge , Neng-Yang Shih
发明人： Francisco Velazquez , Stephane L. Bogen , Ashok Arasappan , Srikanth Venkatraman , F. George Njoroge , Neng-Yang Shih
IPC分类号： A61K38/05
CPC分类号： C07K5/0202 , A61K38/05 , C07D209/52 , C07D401/12 , C07D403/12 , C07D417/12 , C07K5/06008 , C07K5/0804 , A61K2300/00
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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