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1.发明授权Genetically engineered recombinant Escherichia coli producing L-tryptophan having originally L-phenylalanine productivity, and method for producing L-tryptophan using the microorganism 有权生产L-苯丙氨酸生产力的基因工程重组大肠杆菌生产L-色氨酸，以及使用该微生物生产L-色氨酸的方法公开(公告)号：US08945907B2
公开(公告)日：2015-02-03
申请号：US12520350
申请日：2007-12-28
申请人： Jae-yeong Ju , Hyang Choi , Eun-sung Koh , Ji-sun Lee , Jin-ho Lee , So-young Kim , Chang-hyun Jin , Young-hoon Park
发明人： Jae-yeong Ju , Hyang Choi , Eun-sung Koh , Ji-sun Lee , Jin-ho Lee , So-young Kim , Chang-hyun Jin , Young-hoon Park
CPC分类号： C12P13/227 , C12N9/88 , C12N15/52
摘要： The present invention relates to a microorganism having L-tryptophan productivity and a method for producing L-tryptophan using the same. More precisely, the present invention relates to the recombinant E. coli strain CJ600 (KCCM 10812P) having tryptophan productivity produced from the mutant form (KFCC 10066) of E. coli having L-phenylalanine productivity, wherein tryptophan auxotrophy is released, L-phenylalanine biosynthesis is blocked but tryptophan productivity is enhanced by reinforcing the gene involved in tryptophan biosynthesis, and a method of producing L-tryptophan using the same.
摘要翻译： 本发明涉及具有L-色氨酸生产力的微生物和使用其的L-色氨酸的生产方法。 更准确地说，本发明涉及由具有L-苯丙氨酸生产力的大肠杆菌的突变形式（KFCC 10066）产生的具有色氨酸生产力的重组大肠杆菌菌株CJ600（KCCM 10812P），其中色氨酸营养缺陷型被释放，L-苯丙氨酸 生物合成被阻断，但通过加强色氨酸生物合成中涉及的基因来增强色氨酸的生产力，以及使用其生产L-色氨酸的方法。
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2.发明授权Method of producing L-threonine using Escherichia coli strain with phosphoenolpyruvate carboxylase promoter replaced with cysteine synthase promoter 有权使用大肠杆菌菌株产生L-苏氨酸的方法用磷酸烯醇丙酮酸羧化酶启动子替换为半胱氨酸合成酶启动子公开(公告)号：US08486670B2
公开(公告)日：2013-07-16
申请号：US13658369
申请日：2012-10-23
申请人： Kwang Ho Lee , Jae Yeong Ju , Ji Sun Lee , Young Bin Hwang , Sung Hoo Jhon , Eun Sung Koh , Chul Ha Kim , Soo An Shin
发明人： Kwang Ho Lee , Jae Yeong Ju , Ji Sun Lee , Young Bin Hwang , Sung Hoo Jhon , Eun Sung Koh , Chul Ha Kim , Soo An Shin
IPC分类号： C12P13/08
CPC分类号： C12P13/08 , C12N9/1085 , C12N9/88
摘要： An L-threonine-producing Escherichia coli in which a promoter of a phosphoenolpyruvate carboxylase (ppc) gene on the chromosome is substituted with a promoter of a cysteine synthase (cysK) gene and a method of producing L-threonine by using the same are disclosed. The recombinant Escherichia coli may produce L-threonine in a high yield, and thus may be widely used in medical, pharmaceutical, and feed industries, particularly for an animal feed.
摘要翻译： 公开了其中染色体上的磷酸烯醇式丙酮酸羧化酶（ppc）基因的启动子被半胱氨酸合成酶（cysK）基因的启动子取代的产生L-苏氨酸的大肠杆菌以及通过使用它们产生L-苏氨酸的方法 。 重组大肠杆菌可以以高产率生产L-苏氨酸，因此可广泛用于医药，制药和饲料工业，特别是用于动物饲料。
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3.发明授权Microorganism of Enterobacteriacae genus harboring genes associated with L-carnitine biosynthesis and method of producing L-carnitine using the microorganism 有权携带与L-肉碱生物合成相关的基因的肠杆菌属的微生物和使用微生物生产L-肉毒碱的方法公开(公告)号：US07901923B2
公开(公告)日：2011-03-08
申请号：US11720008
申请日：2005-07-19
申请人： Bheong-Uk Lee , Whan-Koo Kang , Young-Hoon Park , Eun-Sung Koh , Sung-Oh Chung , Jae-Yeong Ju
发明人： Bheong-Uk Lee , Whan-Koo Kang , Young-Hoon Park , Eun-Sung Koh , Sung-Oh Chung , Jae-Yeong Ju
CPC分类号： C12N9/0006 , C12N9/0071 , C12N9/88 , C12P13/007
摘要： Provided is a microorganism belonging to the family Enterobacteriaceae including: a polynucleotide encoding N-trimethyllysine hydroxylase activity derived from Neurospora crassa; a polynucleotide encoding 3-hydroxy-6-N-trimethyllysine aldolase activity derived from Neurospora crassa; a polynucleotide encoding γ-trimethylaminoaldehyde dehydrogenase activity derived from Neurospora crassa; and a polynucleotide encoding γ-butyrobetaine hydroxylase activity derived from Neurospora crassa. Provided is also a process for producing L-carnitine using the microorganism.
摘要翻译： 提供属于肠杆菌科的微生物，包括：源自粗糙脉孢菌的N-三甲基赖氨酸羟化酶活性的多核苷酸; 编码源自粗糙脉孢菌的3-羟基-6-N-三甲基赖氨酸醛缩酶活性的多核苷酸; 编码源自粗糙脉孢菌的γ-三甲基氨基醛脱氢酶活性的多核苷酸; 以及编码源自粗糙脉孢菌的γ-丁基甜菜碱羟化酶活性的多核苷酸。 还提供了使用微生物生产L-肉毒碱的方法。
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4.发明申请公开(公告)号：US20080050788A1
公开(公告)日：2008-02-28
申请号：US10590831
申请日：2005-02-25
申请人： Sung Oh Chung , Bheonk-Uk Lee , Whan-Koo Kang , Jae Yeong Ju , Eun Sung Koh , Sung-Sik Park , Young-Hoon Park
发明人： Sung Oh Chung , Bheonk-Uk Lee , Whan-Koo Kang , Jae Yeong Ju , Eun Sung Koh , Sung-Sik Park , Young-Hoon Park
CPC分类号： C12N9/0071 , C12P13/007
摘要： Disclosed is a polynucleotide encoding γ-butyrobetaine hydroxylase (γ-BBH) originating from Neurospora crassa. Also disclosed are a recombinant vector comprising the polynucleotide, a transformant transformed with the recombinant vector, γ-BBH encoded by the polynucleotide, and a method of preparing L-carnitine, which comprises hydroxylating γ-butyrobetaine using γ-BBH encoded by the polynucleotide.
摘要翻译： 公开了编码源于粗糙脉孢菌的γ-丁基甜菜碱羟化酶（γ-BBH）的多核苷酸。 还公开了包含多核苷酸的重组载体，用重组载体转化的转化体，由多核苷酸编码的γ-BBH，以及L-肉毒碱的制备方法，该方法包括使用由多核苷酸编码的γ-BBH羟基化γ-丁基甜菜碱。
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5.发明授权Corynebacterium ammoniagenes KCCM 10340 for producing 5'-xanthylic acid 有权产氨酸棒杆菌KCCM 10340用于产生5'-戊酸公开(公告)号：US06821768B2
公开(公告)日：2004-11-23
申请号：US10322455
申请日：2002-12-19
申请人： Jeong-Hwan Kim , Young-Hyeon Kwag , Jang-Hee Park , Eun-Sung Koh , Yoon-Suk Oh , Jea-Young Chang , Kwang-Ho Lee , Jae-Ick Sim , Jong-Kwon Han , Young-Hoon Park
发明人： Jeong-Hwan Kim , Young-Hyeon Kwag , Jang-Hee Park , Eun-Sung Koh , Yoon-Suk Oh , Jea-Young Chang , Kwang-Ho Lee , Jae-Ick Sim , Jong-Kwon Han , Young-Hoon Park
IPC分类号： C12N100
CPC分类号： C12R1/15 , C12N1/20 , C12P19/32 , Y10S435/843
摘要： The invention relates to microorganism producing 5′-xanthylic acid. A 3,4-dehydro-DL-proline resistant Corynebacterium ammoniagenes CJXPK001 strain is provided for producing 5′-xanthylic acid. It is a mutant strain of Corynebacterium ammoniagenes KFCC 10743 having a lower resistance to 3,4-dehydro-DL-proline. The mutant strain is not affected by osmotic pressure caused by accumulated, highly concentrated solute in a culture medium, and it can produce 5′-xanthylic acid at a high yield and concentration rate.
摘要翻译： 本发明涉及产生5'-戊酸的微生物。提供3,4-脱氢-DL-脯氨酸抗性产氨杆菌CJXPK001菌株以产生5'-戊酸。 它是具有对3,4-脱氢-DL-脯氨酸的较低抗性的产氨棒杆菌KFCC 10743的突变菌株。 突变株不受培养基中积累，高度浓缩的溶质引起的渗透压的影响，可以高产率和浓度产生5'-叶酸。
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6.发明授权Microorganism of Enterobacteriacae genus haboring genes associated with L-carnitine biosynthesis and method of producing L-carnitine using the microorganism 有权具有与L-肉碱生物合成相关的基因的肠杆菌属的微生物和使用微生物生产L-肉毒碱的方法公开(公告)号：US07718414B2
公开(公告)日：2010-05-18
申请号：US11994969
申请日：2006-07-07
申请人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
发明人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
CPC分类号： C12N9/1007 , C12N9/0071 , C12N9/88 , C12P13/007
摘要： Provided is a microorganism that belongs to Enterobacteriacae and a method of producing L-carnitine using the same. The microorganism includes polynucleotide encoding activity of S-adenosylmethionine-6-N-iysine methyltransferase from Neurospora crassa, polynucleotide encoding activity of 6-N-trimethyllysine hydroxylase, polynucleotide encoding activity of 3-hydroxy-6-N-trimethyllysine aldolase, and polynucleotide encoding activity of γ-trimethylaminoaldehyde dehydrogenase and y-butyrobetaine hydroxylase.
摘要翻译： 提供属于肠杆菌属的微生物和使用其的L-肉毒碱的生产方法。 微生物包括编码来自粗糙脉孢菌的S-腺苷甲硫氨酸-6-N-依赖型甲基转移酶的活性的多核苷酸，编码6-N-三甲基赖氨酸羟化酶活性的多核苷酸，编码3-羟基-6-N-三甲基赖氨酸醛缩酶活性的多核苷酸，以及编码 γ-三甲基氨基醛脱氢酶和γ-丁基甜菜碱羟化酶的活性。
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7.发明申请S-Adenosylmethionine-6-N-Lysine-Methyltransferase From Neurospora Crassa, A Gene Encoding The Same, A Vector And Host Cell Containing The Same, And Method For Producing Trimethyllysine Using The Host Cell 有权来自粗糙脉孢菌的S-腺苷甲硫氨酸-6-N-赖氨酸 - 甲基转移酶，编码它的基因，含有它的载体和宿主细胞以及使用宿主细胞产生三甲基赖氨酸的方法公开(公告)号：US20080199920A1
公开(公告)日：2008-08-21
申请号：US11994938
申请日：2006-07-07
申请人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
发明人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
CPC分类号： C12P13/08 , C12N9/1085
摘要： Provided is S-adenosylmethionine-6-N-lysine-methyl-transferase obtained from Neνrospora crassa, a polynucleotide encoding the same, a vector and host cell containing the polynucleotide, and a method of producing trimethyllysine by culturing the host cell.
摘要翻译： 本发明提供从粗核粗核菌（Nenurospora crassa）获得的S-腺苷甲硫氨酸-6-N-赖氨酸甲基转移酶，其编码该多核苷酸的多核苷酸，含有多核苷酸的载体和宿主细胞，以及通过培养宿主细胞产生三甲基赖氨酸的方法。
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8.发明申请Microorganism of Enterobacteriacae Genus Haboring Genes Associated With L-Carnitine Biosynthesis and Method of Producing L-Carnitine Using the Microorganism 有权肠杆菌属微生物与L-肉碱生物合成有关的基因和使用微生物生产L-肉碱的方法公开(公告)号：US20080102488A1
公开(公告)日：2008-05-01
申请号：US11720008
申请日：2005-07-19
申请人： Bheong-Uk Lee , Whan-Koo Kang , Young-Hoon Park , Eun-Sung Koh , Sung-Oh Chung , Jae-Yeong Ju
发明人： Bheong-Uk Lee , Whan-Koo Kang , Young-Hoon Park , Eun-Sung Koh , Sung-Oh Chung , Jae-Yeong Ju
CPC分类号： C12N9/0006 , C12N9/0071 , C12N9/88 , C12P13/007
摘要： Provided is a microorganism belonging to the family Enterobacteriaceae including: a polynucleotide encoding N-trimethyllysine hydroxylase activity derived from Neurospora crassa; a polynucelotide encoding 3-hydroxy-6-N-trimethyllysine aldolase activity derived from Neurospora crassa; a polynucleotide encoding γ-trimethylaminoaldehyde dehydrogenase activity derived from Neurospora crassa; and a polynucleotide encoding γ-butyrobetaine hydroxylase activity derived from Neurospora crassa. Provided is also a process for producing L-carnitine using the microorganism.
摘要翻译： 提供属于肠杆菌科的微生物，包括：源自粗糙脉孢菌的N-三甲基赖氨酸羟化酶活性的多核苷酸; 编码来自粗糙脉孢菌的3-羟基-6-N-三甲基赖氨酸醛缩酶活性的聚季苷化合物; 编码源自粗糙脉孢菌的γ-三甲基氨基醛脱氢酶活性的多核苷酸; 和编码源自粗糙脉孢菌（Crurospora）的γ-丁酸甜菜碱羟化酶活性的多核苷酸。 还提供了使用微生物生产L-肉毒碱的方法。
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公开(公告)号：US08597924B2
公开(公告)日：2013-12-03
申请号：US10590831
申请日：2005-02-25
申请人： Sung Oh Chung , Bheonk-Uk Lee , Whan-Koo Kang , Jae Yeong Ju , Eun Sung Koh , Sung-Sik Park , Young-Hoon Park
发明人： Sung Oh Chung , Bheonk-Uk Lee , Whan-Koo Kang , Jae Yeong Ju , Eun Sung Koh , Sung-Sik Park , Young-Hoon Park
CPC分类号： C12N9/0071 , C12P13/007
摘要： Disclosed is a polynucleotide encoding γ-butyrobetaine hydroxylate (γ-BBH) originating from Neurospora crassa. Also disclosed are a recombinant vector comprising the polynucleotide, a transformant transformed with the recombinant vector, γ-BBH encoded by the polynucleotide, and a method of preparing L-carnitine, which comprises hydroxylating γ-butyrobetaine using γ-BBH encoded by the polynucleotide.
摘要翻译： 公开了编码源于粗糙脉孢菌的γ-丁基甜菜碱羟基化物（γ-BBH）的多核苷酸。 还公开了包含多核苷酸的重组载体，用重组载体转化的转化体，由多核苷酸编码的γ-BBH，以及L-肉毒碱的制备方法，该方法包括使用由多核苷酸编码的γ-BBH羟基化γ-丁基甜菜碱。
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10.发明申请ESCHERICHIA COLI STRAIN WITH ENHANCED L-THREONINE PRODUCTIVITY AND METHOD OF PRODUCING L-THREONINE USING THE SAME 有权具有增强的L-苏氨酸生产力的ESCHERICHIA COLI菌株和使用该柠檬酸生产L-赖氨酸的方法公开(公告)号：US20110189739A1
公开(公告)日：2011-08-04
申请号：US12812203
申请日：2009-01-07
申请人： Kwang Ho Lee , Jae Yeong Ju , Ji Sun Lee , Young Bin Hwang , Sung Hoo Jhon , Eun Sung Koh , Chul Ha Kim , Soo An Shin
发明人： Kwang Ho Lee , Jae Yeong Ju , Ji Sun Lee , Young Bin Hwang , Sung Hoo Jhon , Eun Sung Koh , Chul Ha Kim , Soo An Shin
CPC分类号： C12P13/08 , C12N9/1085 , C12N9/88
摘要： An L-threonine-producing Escherichia coli in which a promoter of a phosphoenolpyruvate carboxylase (ppc) gene on the chromosome is substituted with a promoter of a cysteine synthase (cysK) gene and a method of producing L-threonine by using the same are disclosed. The recombinant Escherichia coli may produce L-threonine in a high yield, and thus may be widely used in medical, pharmaceutical, and feed industries, particularly for an animal feed.
摘要翻译： 公开了其中染色体上的磷酸烯醇式丙酮酸羧化酶（ppc）基因的启动子被半胱氨酸合成酶（cysK）基因的启动子取代的产生L-苏氨酸的大肠杆菌以及通过使用它们产生L-苏氨酸的方法 。 重组大肠杆菌可以以高产率生产L-苏氨酸，因此可广泛用于医药，制药和饲料工业，特别是用于动物饲料。
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