公开(公告)号：US08734499B2

公开(公告)日：2014-05-27

申请号：US11693001

申请日：2007-03-29

申请人： Eric G. Lovett ,  Imad Libbus ,  Joseph Walker

发明人： Eric G. Lovett ,  Imad Libbus ,  Joseph Walker

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61F7/10 ,  A61F2007/0056

摘要： Disclosed herein, among other things, is system for thermal neuroinhibition. According to an embodiment, the system includes at least one implantable fluid-filled conduit adapted to be placed adjacent to a neural target. The system also includes an implantable housing including a power source, a heat pump deriving power from the source and connected to the conduit, and a controller within the housing. The controller is connected to the heat pump, and is adapted to control the heat pump to effect fluid flow in the conduit to cool the neural target using electromechanical refrigeration to reversibly inhibit neural activity as part of a medical treatment.

摘要翻译： 本文公开了除了其它之外，是用于热神经抑制的系统。 根据一个实施例，该系统包括适于邻近神经靶标放置的至少一个可植入流体填充导管。 该系统还包括可植入壳体，该可植入壳体包括电源，源自源并连接到导管的热泵以及壳体内的控制器。 控制器连接到热泵，并且适于控制热泵来实现管道中的流体流动，以使用机电制冷来冷却神经靶标，以可逆地抑制作为医疗治疗的一部分的神经活动。

公开(公告)号：US08600502B2

公开(公告)日：2013-12-03

申请号：US13488962

申请日：2012-06-05

申请人： Eric G. Lovett ,  Robert J. Sweeney ,  Bruce H. KenKnight

发明人： Eric G. Lovett ,  Robert J. Sweeney ,  Bruce H. KenKnight

IPC分类号： A61B5/103 ,  A61B5/117 ,  A61B5/00 ,  A61B5/08 ,  A61N1/00

CPC分类号： A61B5/1116 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/0496 ,  A61B5/1135 ,  A61B5/4809 ,  A61B5/4812 ,  A61B5/686 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0468 ,  A61N1/362

摘要： Systems and methods for sleep state classification involve detecting conditions related to sleep, including at least one condition associated with rapid eye movement (REM) sleep. Additionally, a condition modulated by the sleep-wake status of the patient may be detected. A medical system that is partially or fully implantable incorporates sensors and circuitry for detecting and processing the sleep-related signals. A sleep state processor classifies the patient's sleep state based on the sleep-related signals. Sleep state classification may be used in connection with the delivery of sleep state appropriate therapy, diagnostic testing, or patient monitoring.

摘要翻译： 用于睡眠状态分类的系统和方法涉及检测与睡眠相关的病症，包括与快速眼动（REM）睡眠相关的至少一种病症。 此外，可以检测由患者的睡眠 - 唤醒状态调制的状况。 部分或完全可植入的医疗系统包括用于检测和处理睡眠相关信号的传感器和电路。 睡眠状态处理器根据睡眠相关信号对患者的睡眠状态进行分类。 睡眠状态分类可用于与睡眠状态适当的治疗，诊断测试或患者监测的传递有关。

公开(公告)号：US20120245437A1

公开(公告)日：2012-09-27

申请号：US13488962

申请日：2012-06-05

申请人： Eric G. Lovett ,  Robert J. Sweeney ,  Bruce H. KenKnight

发明人： Eric G. Lovett ,  Robert J. Sweeney ,  Bruce H. KenKnight

IPC分类号： A61B5/0205 ,  A61B5/08 ,  A61N1/00 ,  A61B5/11

CPC分类号： A61B5/1116 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/0496 ,  A61B5/1135 ,  A61B5/4809 ,  A61B5/4812 ,  A61B5/686 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0468 ,  A61N1/362

摘要： Systems and methods for sleep state classification involve detecting conditions related to sleep, including at least one condition associated with rapid eye movement (REM) sleep. Additionally, a condition modulated by the sleep-wake status of the patient may be detected. A medical system that is partially or fully implantable incorporates sensors and circuitry for detecting and processing the sleep-related signals. A sleep state processor classifies the patient's sleep state based on the sleep-related signals. Sleep state classification may be used in connection with the delivery of sleep state appropriate therapy, diagnostic testing, or patient monitoring.

摘要翻译： 用于睡眠状态分类的系统和方法涉及检测与睡眠相关的病症，包括与快速眼动（REM）睡眠相关的至少一种病症。 此外，可以检测由患者的睡眠 - 唤醒状态调制的状况。 部分或完全可植入的医疗系统包括用于检测和处理睡眠相关信号的传感器和电路。 睡眠状态处理器根据睡眠相关信号对患者的睡眠状态进行分类。 睡眠状态分类可用于与睡眠状态适当的治疗，诊断测试或患者监测的传递有关。

公开(公告)号：US08239021B2

公开(公告)日：2012-08-07

申请号：US12816088

申请日：2010-06-15

申请人： Eric G. Lovett

发明人： Eric G. Lovett

IPC分类号： A61N1/00

CPC分类号： A61N1/3622 ,  A61N1/3956

摘要： A cardiac pacing system preventing short-long-short pacing sequences. The system providing pacing pulses where necessary. The system having dynamic event window generation to adapt to changes in heart rate. The event window adaptable to process a number of intervals. The system including provisions for other inputs, such as sensor and morphology detection. The system adaptable for single mode and dual mode applications. The system also applicable to long pause prevention in atrial pacing and ventricular pacing.

摘要翻译： 心脏起搏系统可以预防长时间短的起搏序列。 系统在必要时提供起搏脉冲。 该系统具有适应心率变化的动态事件窗口生成。 事件窗口适应于处理多个间隔。 该系统包括其他输入的规定，如传感器和形态检测。 该系统适用于单模和双模应用。 该系统还适用于心房起搏和心室起搏的长时间停止预防。

公开(公告)号：US08192376B2

公开(公告)日：2012-06-05

申请号：US10643006

申请日：2003-08-18

申请人： Eric G. Lovett ,  Robert J. Sweeney ,  Bruce H. Kenknight

发明人： Eric G. Lovett ,  Robert J. Sweeney ,  Bruce H. Kenknight

IPC分类号： A61B5/103 ,  A61B5/117 ,  A61B5/04 ,  A61N1/00

CPC分类号： A61B5/1116 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/0496 ,  A61B5/1135 ,  A61B5/4809 ,  A61B5/4812 ,  A61B5/686 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0468 ,  A61N1/362

摘要： Systems and methods for sleep state classification involve detecting conditions related to sleep, including at least one condition associated with rapid eye movement (REM) sleep. Additionally, a condition modulated by the sleep-wake status of the patient may be detected. A medical system that is partially or fully implantable incorporates sensors and circuitry for detecting and processing the sleep-related signals. A sleep state processor classifies the patient's sleep state based on the sleep-related signals. Sleep state classification may be used in connection with the delivery of sleep state appropriate therapy, diagnostic testing, or patient monitoring.

摘要翻译： 用于睡眠状态分类的系统和方法涉及检测与睡眠相关的病症，包括与快速眼动（REM）睡眠相关的至少一种病症。 此外，可以检测由患者的睡眠 - 唤醒状态调制的状况。 部分或完全可植入的医疗系统包括用于检测和处理睡眠相关信号的传感器和电路。 睡眠状态处理器根据睡眠相关信号对患者的睡眠状态进行分类。 睡眠状态分类可用于与睡眠状态适当的治疗，诊断测试或患者监测的传递有关。

公开(公告)号：US07894893B2

公开(公告)日：2011-02-22

申请号：US10955831

申请日：2004-09-30

申请人： Jaeho Kim ,  Joseph Bocek ,  Eric G. Lovett

发明人： Jaeho Kim ,  Joseph Bocek ,  Eric G. Lovett

IPC分类号： A61N1/02

CPC分类号： A61B5/7264 ,  A61B5/04525

摘要： Different types of cardiac arrhythmia are classified based on the morphology of the arrhythmic beats. Cardiac beats associated with an arrhythmic episode are compared to a plurality of representative beat morphologies, each representative beat morphology characterizing a type of arrhythmia of the heart. An arrhythmic episode may be classified as a particular type of arrhythmia if the morphology of the arrhythmic cardiac beats matches a representative beat morphology characterizing the particular type of arrhythmia. An appropriate therapy for the particular type of arrhythmia may be selected based on the arrhythmia classification. A particular type of arrhythmia may be associated with one or more therapies used to treat the arrhythmia. The therapy used to treat the arrhythmia may comprise a therapy identified as a previously successful therapy.

摘要翻译： 基于心律失常节律的形态分类不同类型的心律失常。 与心律失常发作相关的心脏搏动与多个代表性搏动形态进行比较，每个代表性搏动形态表征心脏心律失常的类型。 如果心律失常心跳的形态与表征特定类型的心律失常的代表性搏动形态匹配，则心律失常发作可被分类为特定类型的心律失常。 可以基于心律失常分类来选择针对特定类型的心律失常的适当疗法。 特定类型的心律失常可能与用于治疗心律失常的一种或多种治疗相关联。 用于治疗心律失常的治疗可以包括被确定为先前成功的治疗的治疗。

公开(公告)号：US20110021934A1

公开(公告)日：2011-01-27

申请号：US12895151

申请日：2010-09-30

申请人： Jaeho Kim ,  Joseph M. Bocek ,  Julie A. Thompson ,  Eric G. Lovett

发明人： Jaeho Kim ,  Joseph M. Bocek ,  Julie A. Thompson ,  Eric G. Lovett

IPC分类号： A61B5/0464 ,  A61B5/02

CPC分类号： A61N1/3962 ,  A61B5/04525 ,  A61B5/7264 ,  A61N1/3622 ,  A61N1/3925 ,  A61N1/395

摘要： Systems and methods are described for classifying a cardiac rhythm. A cardiac rhythm is classified using a classification process that includes a plurality of cardiac rhythm discriminators. Each rhythm discriminator provides an independent classification of the cardiac rhythm. The classification process is modified if the modification is likely to produce enhanced classification results. The rhythm is reclassified using the modified classification process.

摘要翻译： 描述了用于分类心律的系统和方法。 使用包括多个心律识别器的分类处理对心律进行分类。 每个节律鉴别器提供心脏节律的独立分类。 如果修改可能产生增强的分类结果，则修改分类过程。 使用修改的分类过程重新分类节奏。

公开(公告)号：US07353062B2

公开(公告)日：2008-04-01

申请号：US10746857

申请日：2003-12-24

申请人： Jaeho Kim ,  Joseph M. Bocek ,  Eric G. Lovett

发明人： Jaeho Kim ,  Joseph M. Bocek ,  Eric G. Lovett

IPC分类号： A61N1/39

CPC分类号： A61B5/0464 ,  A61N1/3925 ,  A61N1/3962

摘要： A cardiac rhythm management device is configured to discriminate between ventricular and supraventricular tachycardias (referred to as SVT/VT discrimination) by utilizing a morphology criterion in which the morphology of electrogram waveforms during ventricular beats are analyzed to determine if the beats are normally conducted. After the delivery of a cardioversion/defibrillation shock, however, the intraventricular conduction system is left in a modified state which alters the subsequently generated electrogram signal. Use of the morphology criterion for SVT/VT discrimination is discontinued after delivery of such a shock and resumed after a predetermined minimum number of normally conducted ventricular beats has been detected.

摘要翻译： 心律管理装置被配置为通过利用形态学标准来区分心室和室上性心动过速（称为SVT / VT鉴别），其中分析心室搏动时的电描记图波形的形态以确定节拍是否正常进行。 然而，在输出心脏复律/除颤休克之后，心室内传导系统处于改变随后产生的电描记图信号的修改状态。 在发生这种休克后，停止使用SVT / VT鉴别的形态学标准，并且在检测到预定的最小数量的正常进行的心室搏动之后恢复。

公开(公告)号：US07294109B2

公开(公告)日：2007-11-13

申请号：US10663920

申请日：2003-09-16

申请人： Eric G. Lovett ,  Robert J. Sweeney

发明人： Eric G. Lovett ,  Robert J. Sweeney

IPC分类号： A61B5/02

CPC分类号： H03H21/0043 ,  A61B5/04017 ,  A61B5/0428 ,  A61B5/7203 ,  A61N1/3956 ,  H03H17/026

摘要： A method and apparatus for implementing a signal morphology preservation smoothing scheme. The smoothing scheme includes generating an output signal representative of a filtered version of the input signal, wherein the output signal is generated by adaptively removing low amplitude, high frequency noise components while simultaneously preserving signal morphology of the input signal. The smoothing scheme includes comparison of a distance metric against a distance threshold to determine whether an initial smoothed version of the input signal would be oversmoothed or undersmoothed. Then the smoothing scheme appropriately increments, decrements, or maintains the initial level of smoothing to generate an optimal smoothed signal representative of the output signal.

摘要翻译： 一种实现信号形态保存平滑方案的方法和装置。 平滑方案包括产生表示输入信号的滤波版本的输出信号，其中通过自适应地去除低幅度高频噪声分量而产生输出信号，同时保持输入信号的信号形态。 平滑方案包括距离度量与距离阈值的比较，以确定输入信号的初始平滑版本是否将被过度平缓或不足够的。 然后平滑方案适当地增加，减少或维持平滑的初始水平，以产生表示输出信号的最佳平滑信号。

公开(公告)号：US07142912B2

公开(公告)日：2006-11-28

申请号：US10194435

申请日：2002-07-12

申请人： Darrell O. Wagner ,  Robert J. Sweeney ,  Adam W. Cates ,  Apurv Kamath ,  Eric G. Lovett

发明人： Darrell O. Wagner ,  Robert J. Sweeney ,  Adam W. Cates ,  Apurv Kamath ,  Eric G. Lovett

IPC分类号： A61N1/08

CPC分类号： A61N1/3622 ,  A61N1/395 ,  A61N1/3962

摘要： A method and apparatus for assessing the risk of atrial fibrillation in a patient by calculating the relative frequency of short and long intervals between successive heart beats during sinus rhythm is presented. An imbalance of short over long sinus intervals has been found to indicate a higher risk of atrial fibrillation. An implantable cardiac device may be configured to automatically deliver interventional therapy to restore sinus interval balance when such an imbalance is detected.

摘要翻译： 提出了一种通过计算窦性心律连续心脏跳动之间的短间隔和长间隔的相对频率来评估患者心房颤动风险的方法和装置。 发现短窦间隔短暂的不平衡表明心房颤动的风险更高。 可植入的心脏装置可以被配置为当检测到这种不平衡时，自动地进行介入治疗以恢复窦间隔平衡。