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1.发明授权Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof 有权靶向EGF受体的单克隆抗体175及其衍生物及其用途公开(公告)号：US09283276B2
公开(公告)日：2016-03-15
申请号：US12733146
申请日：2008-08-14
申请人： Terrance Grant Johns , Elizabeth Stockert , Stephen Stockert , Lloyd J. Old , Andrew M. Scott , Veronika M. Rayzman
发明人： Terrance Grant Johns , Elizabeth Stockert , Lloyd J. Old , Andrew M. Scott , Veronika M. Rayzman
IPC分类号： C12P21/08 , A61K45/06 , G01N33/574 , G01N33/74 , A61K39/395 , C07K16/28 , G01N33/50 , A61K39/00
CPC分类号： A61K45/06 , A61K39/395 , A61K2039/505 , C07K16/2863 , C07K2299/00 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/92 , G01N33/5091 , G01N33/57492 , G01N33/74 , A61K2300/00
摘要： The present invention relates to antibodies, particularly antibody 175, and fragments thereof or antibodies derived therefrom, which bind to the EGF receptor, particularly to amplified or overexpressed epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. These antibodies are useful in the diagnosis and treatment of cancer. Recombinant or hybrid antibodies having the variable region heavy or light chain sequence(s) of antibody 175 are also provided. The antibodies of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译： 本发明涉及结合EGF受体，特别是与扩增或过表达的表皮生长因子受体（EGFR）和EGFR的de2-7 EGFR截短的抗体，特别是抗体175及其衍生的抗体或抗体。 这些抗体可用于诊断和治疗癌症。 还提供了具有抗体175的可变区重链或轻链序列的重组或杂合抗体。 本发明的抗体也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。
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公开(公告)号：US20110293511A1
公开(公告)日：2011-12-01
申请号：US13078781
申请日：2011-04-01
申请人： Terrance Grant Johns , Andrew Mark Scott , Gerd Ritter , Achim Jungbluth , Elizabeth Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Lloyd J. Old , Edward B. Reilly , Andrew C. Phillips , Jonathan A. Meulbroek , Fritz G. Buchanan , Stephen Stockert
发明人： Terrance Grant Johns , Andrew Mark Scott , Gerd Ritter , Achim Jungbluth , Elizabeth Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Lloyd J. Old , Edward B. Reilly , Andrew C. Phillips , Jonathan A. Meulbroek , Fritz G. Buchanan , Stephen Stockert
IPC分类号： A61K39/395 , A61K38/21 , A61K38/20 , A61K103/20 , A61K103/40 , A61K103/30 , A61K103/32 , A61K103/00 , A61P35/00
CPC分类号： C07K16/4266 , A61K39/39558 , A61K51/103 , A61K51/1045 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
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3.发明授权Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof 有权编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US06911529B1
公开(公告)日：2005-06-28
申请号：US09602362
申请日：2000-06-22
申请人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-tseng Chen
发明人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-tseng Chen
CPC分类号： C07K14/47
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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4.发明授权Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof 有权编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US06774226B1
公开(公告)日：2004-08-10
申请号：US09451739
申请日：1999-11-30
申请人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-tseng Chen
发明人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-tseng Chen
IPC分类号： C07H2104
CPC分类号： C07K14/47
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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公开(公告)号：US20110313230A1
公开(公告)日：2011-12-22
申请号：US13078764
申请日：2011-04-01
申请人： Terrance Grant Johns , Andrew Mark Scott , Gerd Ritter , Achim Jungbluth , Elizabeth Stockert , Stephen Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Lloyd J. Old , Edward B. Reilly , Andrew C. Phillips , Jonathan A. Meulbroek , Fritz G. Buchanan
发明人： Terrance Grant Johns , Andrew Mark Scott , Gerd Ritter , Achim Jungbluth , Elizabeth Stockert , Stephen Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Lloyd J. Old , Edward B. Reilly , Andrew C. Phillips , Jonathan A. Meulbroek , Fritz G. Buchanan
CPC分类号： A61K39/3955 , A61K39/39541 , A61K39/39558 , A61K45/06 , A61K51/103 , A61K51/1045 , A61K51/1078 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2863 , C07K16/30 , C07K16/4241 , C07K16/4258 , C07K16/4266 , C07K2299/00 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/90 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译： 本发明涉及在过表达EGFR的肿瘤细胞上结合EGFR的特异性结合成员，特别是抗体及其片段，以及表达EGFR受体截短型de2-7EGF的肿瘤细胞。 特别地，特异性结合成员识别的表位，特别是其抗体及其片段，在异常翻译后修饰时增强或明显。 这些特异性结合成员可用于癌症的诊断和治疗。 本发明的结合成员也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。
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6.发明申请MONOCLONAL ANTIBODY 175 TAGETING THE EGF RECEPTOR AND DERIVATIVES AND USES THEREOF 有权单克隆抗体175报告EGF受体及其衍生物及其用途公开(公告)号：US20110150759A1
公开(公告)日：2011-06-23
申请号：US12733146
申请日：2008-08-14
IPC分类号： C07K16/30 , C12N15/13 , C12N15/85 , C12P21/08 , G01N33/574 , A61K51/10 , C12N1/21 , C12N1/19 , C12N5/10 , A61P35/04
CPC分类号： A61K45/06 , A61K39/395 , A61K2039/505 , C07K16/2863 , C07K2299/00 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/92 , G01N33/5091 , G01N33/57492 , G01N33/74 , A61K2300/00
摘要： The present invention relates to antibodies, particularly antibody 175, and fragments thereof or antibodies derived therefrom, which bind to the EGF receptor, particularly to amplified or overexpressed epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. These antibodies are useful in the diagnosis and treatment of cancer. Recombinant or hybrid antibodies having the variable region heavy or light chain sequence(s) of antibody 175 are also provided. The antibodies of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译： 本发明涉及结合EGF受体，特别是与扩增或过表达的表皮生长因子受体（EGFR）和EGFR的de2-7 EGFR截短的抗体，特别是抗体175及其衍生的抗体或抗体。 这些抗体可用于诊断和治疗癌症。 还提供了具有抗体175的可变区重链或轻链序列的重组或杂合抗体。 本发明的抗体也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。
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公开(公告)号：US20110076232A1
公开(公告)日：2011-03-31
申请号：US12890029
申请日：2010-09-24
申请人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew Mark Scott , Christoph Renner , Achim Jungbluth , Elizabeth Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Gerd Ritter
发明人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew Mark Scott , Christoph Renner , Achim Jungbluth , Elizabeth Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark , Gerd Ritter
IPC分类号： A61K51/10 , C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2863 , A61K39/39558 , A61K51/103 , A61K51/1045 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/30 , C07K16/4266 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译： 本发明涉及结合扩增的表皮生长因子受体（EGFR）和EGFR的de2-7 EGFR截短的特异性结合成员，特别是抗体及其片段。 特别地，特异性结合成员识别的表位，特别是其抗体及其片段，在异常翻译后修饰时增强或明显。 这些特异性结合成员可用于癌症的诊断和治疗。 本发明的结合成员也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。
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8.发明授权Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof 有权编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US06448073B1
公开(公告)日：2002-09-10
申请号：US09493914
申请日：2000-01-28
申请人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-tseng Chen
发明人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-tseng Chen
IPC分类号： C12N1563
CPC分类号： C07K14/4748 , A61K39/00 , C12N2799/022 , C12N2799/023 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to isolated, cancer associated antigens, nucleic acid molecules, and various uses thereof.
摘要翻译： 本发明涉及分离的癌相关抗原，核酸分子及其各种用途。
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9.发明授权公开(公告)号：US07132507B2
公开(公告)日：2006-11-07
申请号：US10153318
申请日：2002-05-21
申请人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
发明人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
CPC分类号： C07K14/4748 , A61K39/00 , C12N2799/022 , C12N2799/023 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to isolated, cancer associated antigens, nucleic acid molecules, and various uses thereof.
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