公开(公告)号：US07799548B2

公开(公告)日：2010-09-21

申请号：US11732992

申请日：2007-04-05

Applicant: Michelle B. Arora ,  Jamie A. Hestekin ,  YuPo J. Lin ,  Edward J. St. Martin ,  Seth W. Snyder

Inventor： Michelle B. Arora ,  Jamie A. Hestekin ,  YuPo J. Lin ,  Edward J. St. Martin ,  Seth W. Snyder

IPC: C12N9/00 ,  C12N11/02 ,  C12N11/08 ,  C12P1/00 ,  C12M1/00 ,  C07K1/14 ,  C07K1/22 ,  C07K1/24 ,  C07K17/02 ,  C07K17/08

CPC classification number: B01D61/425 ,  B01D61/48 ,  B01J20/3265 ,  B01J47/00 ,  B01J47/018 ,  B01J47/08 ,  Y10S530/812 ,  Y10S530/815

Abstract: A porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin within said wafer. Also disclosed is a porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin within said wafer containing a biomolecule with a tag. A separate bioreactor is also disclosed incorporating the wafer described above.

Abstract translation: 具有在所述晶片内形成带电捕获树脂的生物分子捕获树脂和离子交换树脂的组合的多孔固体离子交换晶片。 还公开了具有生物分子捕获树脂和离子交换树脂的组合的多孔固体离子交换晶片，所述离子交换树脂在所述含有标签的生物分子的晶片内形成带电捕获树脂。 还公开了单独的生物反应器，其结合了上述晶片。

公开(公告)号：US4927760A

公开(公告)日：1990-05-22

申请号：US366726

申请日：1989-06-15

Applicant: Edward J. St. Martin

Inventor： Edward J. St. Martin

IPC: C09B61/00 ,  C12P1/02

CPC classification number: C09B61/00 ,  C12P1/02 ,  Y10S435/911

Abstract: Both the ease and cost of isolating the water insoluble orange pigment produced as a secondary metabolite by Monascus species can be substantially improved by inducing crystalline pigment formation directly in the culture medium. Poly(oxyethylene)sorbitan esters of palmitic acid are especially effective and cause the formation of large crystals. Another class of crystalline pigment inducing agents is that of the liquid vegetable oils, although generally these lead to smaller crystal sizes.

Abstract translation: 通过直接在培养基中诱导结晶色素，可以显着地改善由红曲霉物种分离作为次级代谢物产生的水不溶性橙色颜料的容易性和成本。 棕榈酸的聚（氧乙烯）脱水山梨糖醇酯特别有效，并引起大晶体的形成。 另一类结晶色素诱导剂是液体植物油的一种，尽管通常这些会导致更小的晶体尺寸。

公开(公告)号：US08507229B2

公开(公告)日：2013-08-13

申请号：US12767168

申请日：2010-04-26

Applicant: YuPo J. Lin ,  Edward J. St. Martin

Inventor： YuPo J. Lin ,  Edward J. St. Martin

IPC: C12P7/62 ,  C12P7/20 ,  C12P5/00 ,  B01D61/44 ,  B01D61/48

CPC classification number: C10L1/026 ,  B01D61/48 ,  C10L2270/026 ,  C11C3/003 ,  Y02E50/13

Abstract: The present invention relates to an integrated method and system for the simultaneous production of biodiesel from free fatty acids (via esterification) and from triglycerides (via transesterification) within the same reaction chamber. More specifically, one preferred embodiment of the invention relates to a method and system for the production of biodiesel using an electrodeionization stack, wherein an ion exchange resin matrix acts as a heterogeneous catalyst for simultaneous esterification and transesterification reactions between a feedstock and a lower alcohol to produce biodiesel, wherein the feedstock contains significant levels of free fatty acid. In addition, because of the use of a heterogeneous catalyst, the glycerol and biodiesel have much lower salt concentrations than raw biodiesel produced by conventional transesterification processes. The present invention makes it much easier to purify glycerol and biodiesel.

Abstract translation: 本发明涉及在同一反应室内同时从游离脂肪酸（通过酯化）和甘油三酸酯（通过酯交换）生产生物柴油的综合方法和系统。 更具体地，本发明的一个优选实施方案涉及使用电去离子反应堆生产生物柴油的方法和系统，其中离子交换树脂基质用作用于原料和低级醇之间的同时酯化和酯交换反应的多相催化剂， 生产生物柴油，其中原料含有显着水平的游离脂肪酸。 此外，由于使用多相催化剂，甘油和生物柴油的盐浓度远低于通过常规酯交换法生产的生物柴油。 本发明使甘油和生物柴油更容易净化。

公开(公告)号：US20130081947A1

公开(公告)日：2013-04-04

申请号：US13248231

申请日：2011-09-29

Applicant: Edward J. ST. MARTIN ,  YuPo J. LIN

Inventor： Edward J. ST. MARTIN ,  YuPo J. LIN

IPC: B01D61/44 ,  B01D61/48

CPC classification number: C12P7/46 ,  B01D61/445 ,  B01D61/48 ,  B01D2311/2688 ,  C12M47/10

Abstract: A method for producing succinic acid is provided, which comprises circulating a fermentation broth containing succinate ion through an electrodeionization apparatus. The apparatus comprises an anode; a cathode; a stacked ion-exchange assembly comprising a one or more oriented ion-exchange units between the anode and the cathode. Each ion-exchange unit comprises a porous ion-exchange resin wafer including an inlet and an outlet together are adapted to circulate a liquid reaction stream containing a carboxylate anion from a fermentor through the resin wafer; a flow-distributing gasket for circulating a product stream through a product reservoir; an anion exchange membrane for transporting at least a portion of the carboxylate anion to the product stream; and a bipolar ion-exchange membrane to direct protons toward the cathode and into the product stream and to direct hydroxyl ions toward the anode and into the reaction stream in the resin wafer of an adjacent ion-exchange unit.

Abstract translation: 提供了一种生产琥珀酸的方法，其包括使含有琥珀酸离子的发酵液循环通过电去离子装置。 该装置包括阳极; 阴极 包括在阳极和阴极之间的一个或多个取向离子交换单元的层叠离子交换组件。 每个离子交换单元包括多孔离子交换树脂晶片，其包括入口和出口，一起适于使含有羧酸根阴离子的液体反应物流从发酵罐循环通过树脂晶片; 用于使产品流循环通过产品储存器的流量分配垫圈; 用于将至少一部分羧酸根阴离子输送到产物流的阴离子交换膜; 和双极离子交换膜，以将质子引向阴极并进入产物流，并将羟基离子引向阳极并进入相邻离子交换单元的树脂晶片中的反应流中。

公开(公告)号：US20100261921A1

公开(公告)日：2010-10-14

申请号：US12767168

申请日：2010-04-26

Applicant: YuPo J. Lin ,  Edward J. St. Martin

Inventor： YuPo J. Lin ,  Edward J. St. Martin

IPC: C11C3/04 ,  B01J19/08

CPC classification number: C10L1/026 ,  B01D61/48 ,  C10L2270/026 ,  C11C3/003 ,  Y02E50/13

Abstract: The present invention relates to an integrated method and system for the simultaneous production of biodiesel from free fatty acids (via esterification) and from triglycerides (via transesterification) within the same reaction chamber. More specifically, one preferred embodiment of the invention relates to a method and system for the production of biodiesel using an electrodeionization stack, wherein an ion exchange resin matrix acts as a heterogeneous catalyst for simultaneous esterification and transesterification reactions between a feedstock and a lower alcohol to produce biodiesel, wherein the feedstock contains significant levels of free fatty acid. In addition, because of the use of a heterogeneous catalyst, the glycerol and biodiesel have much lower salt concentrations than raw biodiesel produced by conventional transesterification processes. The present invention makes it much easier to purify glycerol and biodiesel.

Abstract translation: 本发明涉及在同一反应室内同时从游离脂肪酸（通过酯化）和甘油三酸酯（通过酯交换）生产生物柴油的综合方法和系统。 更具体地，本发明的一个优选实施方案涉及使用电去离子反应堆生产生物柴油的方法和系统，其中离子交换树脂基质用作用于原料和低级醇之间的同时酯化和酯交换反应的多相催化剂， 生产生物柴油，其中原料含有显着水平的游离脂肪酸。 此外，由于使用多相催化剂，甘油和生物柴油的盐浓度远低于通过常规酯交换法生产的生物柴油。 本发明使甘油和生物柴油更容易净化。

公开(公告)号：US07141154B2

公开(公告)日：2006-11-28

申请号：US10794231

申请日：2004-03-05

Applicant: YuPo J. Lin ,  Michael Henry ,  Jamie Hestekin ,  Seth W. Snyder ,  Edward J. St. Martin

Inventor： YuPo J. Lin ,  Michael Henry ,  Jamie Hestekin ,  Seth W. Snyder ,  Edward J. St. Martin

IPC: B01D61/48 ,  B01D61/44

CPC classification number: B01D61/48 ,  C07C67/08 ,  C07C69/68

Abstract: A method of and apparatus for continuously making an organic ester from a lower alcohol and an organic acid is disclosed. An organic acid or salt is introduced or produced in an electrode ionization (EDI) stack with a plurality of reaction chambers each formed from a porous solid ion exchange resin wafer interleaved between anion exchange membranes or an anion exchange membrane and a cation exchange membrane or an anion exchange membrane and a bipolar exchange membranes. At least some reaction chambers are esterification chambers and/or bioreactor chambers and/or chambers containing an organic acid or salt. A lower alcohol in the esterification chamber reacts with an anion to form an organic ester and water with at least some of the water splitting with the ions leaving the chamber to drive the reaction.

Abstract translation: 公开了从低级醇和有机酸连续制备有机酯的方法和设备。 在具有多个反应室的电极离子化（EDI）堆叠中引入或制造有机酸或盐，所述多个反应室由在阴离子交换膜或阴离子交换膜和阳离子交换膜之间交错的多孔固体离子交换树脂晶片形成， 阴离子交换膜和双极交换膜。 至少一些反应室是含有有机酸或盐的酯化室和/或生物反应器室和/或室。 酯化室中的低级醇与阴离子反应形成有机酯和水，其中至少一些水分离离子离开室以驱动反应。

公开(公告)号：US06294074B1

公开(公告)日：2001-09-25

申请号：US09573575

申请日：2000-05-18

Applicant: YuPo J. Lin ,  Edward J. St. Martin ,  James R. Frank ,  Daniel H. Pope

Inventor： YuPo J. Lin ,  Edward J. St. Martin ,  James R. Frank ,  Daniel H. Pope

IPC: G01N2726

CPC classification number: G01N17/02

Abstract: An electrode design is provided for corrosion monitoring using electrochemical noise measurements. Electrochemical probes are used for sensing electrochemical noise voltage values and electrochemical noise current values. The electrochemical probes include a pair of working electrodes formed of the same material of the monitored metal pipes or storage vessels and a reference electrode formed of a corrosion resistant material. Each of the pair of working electrodes has a defined surface roughness. One of the pair of working electrodes has reduced roughness, whereby sensitivity to sustained localized pitting corrosion is increased in the working electrode with reduced roughness. By reducing the surface roughness of one of the pair of working electrodes, increased sensitivity to sustained localized pitting corrosion is provided while the current noise can be used to accurately measure the general corrosion rate on the unpolished electrode.

Abstract translation: 提供电极设计用于使用电化学噪声测量的腐蚀监测。 电化学探针用于检测电化学噪声电压值和电化学噪声电流值。 电化学探针包括由监测的金属管或储存容器的相同材料形成的一对工作电极和由耐腐蚀材料形成的参比电极。 一对工作电极中的每一个具有限定的表面粗糙度。 一对工作电极之一减少了粗糙度，从而在工作电极中对持续的局部点腐蚀的敏感性增加，其粗糙度降低。 通过降低一对工作电极之一的表面粗糙度，提供对持续局部点蚀的增加的敏感性，同时可以使用电流噪声来精确测量未抛光电极上的一般腐蚀速率。

公开(公告)号：US5013565A

公开(公告)日：1991-05-07

申请号：US562879

申请日：1990-08-03

Applicant: Edward J. St. Martin ,  Paul R. Kurek ,  Elaine F. Schumacher

Inventor： Edward J. St. Martin ,  Paul R. Kurek ,  Elaine F. Schumacher

IPC: A23L1/275 ,  C09B61/00

CPC classification number: C09B61/00 ,  A23L5/46 ,  A23L5/47 ,  Y10S435/911

Abstract: The orange, water-insoluble pigments monascorubrin and rubropunctatin elaborated by Monascus species can be converted to high purity red, water-soluble pigments by reaction with stoichiometric quantities of organic materials bearing a primary amine functionality. These pigments are suitable as colorants for a broad variety of edible formulations, especially those intended for human consumption, and often serve as suitable replacements for FD&C Red No. 2 and Red No. 4.

Abstract translation: 通过与化学计量的具有伯胺官能团的有机材料反应，橙红色水不溶性颜料红曲霉素和红曲霉素由红曲霉物质制成，可以转化为高纯度的红色水溶性颜料。 这些颜料适合作为各种可食用配方的着色剂，特别是用于人类消费的食品，并且通常用作FD＆C红2号和红4号的合适替代品。

公开(公告)号：US5013564A

公开(公告)日：1991-05-07

申请号：US562880

申请日：1990-08-03

Applicant: Edward J. St. Martin ,  Paul R. Kurek ,  Elaine F. Schumacher ,  Ronald P. Rohrbach

Inventor： Edward J. St. Martin ,  Paul R. Kurek ,  Elaine F. Schumacher ,  Ronald P. Rohrbach

IPC: A23L1/275 ,  C09B61/00

CPC classification number: C09B61/00 ,  A23L5/46 ,  A23L5/47 ,  Y10S435/911

Abstract: The yellow pigments which result from reaction of the Monascus pigments monascorubrin and rubropunctatin with amines followed by reduction of the ring carbonyl moiety to an hydroxyl group have excellent properties for their use as food colorants. Yellow pigments made from amino acid esters, dipeptide esters, and amines of sugar alcohols have particular promise as desirable food colorants which are effective at levels which impart no objectionable taste to foods.

Abstract translation: 由红曲霉色素monascorubrin和rubropunctatin与胺反应产生的黄色颜料，随后将羰基部分还原成羟基，它们用作食品着色剂具有优异的性能。 由氨基酸酯，二肽酯和糖醇制成的黄色颜料具有特别的希望，作为所希望的食品着色剂，其在对食物不产生令人不快的味道的水平上是有效的。

公开(公告)号：US5888374A

公开(公告)日：1999-03-30

申请号：US855707

申请日：1997-05-08

Applicant: Daniel H. Pope ,  YuPo J. Lin ,  Edward J. St. Martin ,  James R. Frank

Inventor： Daniel H. Pope ,  YuPo J. Lin ,  Edward J. St. Martin ,  James R. Frank

IPC: G01N17/02 ,  G01N27/26

CPC classification number: G01N17/02

Abstract: A method and apparatus are provided for monitoring localized pitting corrosion in metal pipes or storage vessels. Electrochemical probes are used for sensing electrochemical noise voltage values and electrochemical noise current values. The root-mean-square electrochemical noise current and voltage values are calculated and stored for the sensed electrochemical noise voltage values and the electrochemical noise current values. The stored electrochemical noise current and voltage values are processed by transforming the stored electrochemical noise current and voltage values into power spectral density data utilizing a fast Fourier transform. A slope of the power spectral density data relative to frequency is calculated. The electrochemical probes include a pair of working electrodes formed of the same material of the monitored metal pipes or storage vessels and a reference electrode formed of a corrosion resistant material. A linear slope of a low-frequency portion of the power spectral density data is calculated by using a least-square method.

Abstract translation: 提供了一种用于监测金属管或储存容器中局部点腐蚀的方法和装置。 电化学探针用于检测电化学噪声电压值和电化学噪声电流值。 计算并存储均方根电化学噪声电流和电压值，用于感测的电化学噪声电压值和电化学噪声电流值。 通过使用快速傅里叶变换将存储的电化学噪声电流和电压值转换成功率谱密度数据来处理存储的电化学噪声电流和电压值。 计算相对于频率的功率谱密度数据的斜率。 电化学探针包括由监测的金属管或储存容器的相同材料形成的一对工作电极和由耐腐蚀材料形成的参比电极。 利用最小二乘法计算功率谱密度数据的低频部分的线性斜率。