公开(公告)号：US20240360223A1

公开(公告)日：2024-10-31

申请号：US18622766

申请日：2024-03-29

Applicant: Dragonfly Therapeutics, Inc.

Inventor： Aaron BELLI ,  Ann F. CHEUNG ,  Stacey V. DRABIC ,  Daniel FALLON ,  Benjamin FISCHER ,  Asya GRINBERG ,  Pyae P. HEIN ,  Alexander IVANOV ,  Zong Sean JUO ,  Mark LEWANDOWSKI ,  Xinbi LI ,  Matthew SCHNEIDER

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2851 ,  C07K16/283 ,  C07K16/2878 ,  A61K39/00 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76

Abstract: Multispecific binding proteins that bind NKG2D receptor, CD16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.

公开(公告)号：US20240270861A1

公开(公告)日：2024-08-15

申请号：US18620824

申请日：2024-03-28

Applicant: Dragonfly Therapeutics, Inc.

Inventor： Aaron BELLI ,  Ann F. CHEUNG ,  Stacey V. DRABIC ,  Daniel FALLON ,  Benjamin FISCHER ,  Asya GRINBERG ,  Pyae P. HEIN ,  Alexander IVANOV ,  Zong Sean JUO ,  Mark LEWANDOWSKI ,  Xinbi LI ,  Matthew SCHNEIDER

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2878 ,  A61P35/00 ,  C07K16/283 ,  C07K16/2851 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2319/21

Abstract: Multispecific binding proteins that bind NKG2D receptor, CD16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.

公开(公告)号：US20240166753A1

公开(公告)日：2024-05-23

申请号：US18482629

申请日：2023-10-06

Applicant: Dragonfly Therapeutics, Inc.

Inventor： Gregory P. Chang ,  Ann F. Cheung ,  William Haney ,  Asya Grinberg

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K16/32 ,  C07K16/46

CPC classification number: C07K16/2851 ,  A61P35/00 ,  C07K16/2803 ,  C07K16/283 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/468 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/569 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/94

Abstract: Multi-specific binding proteins that bind a tumor associated antigen, the NKG2D receptor, and CD16 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.

公开(公告)号：US11884732B2

公开(公告)日：2024-01-30

申请号：US16486569

申请日：2018-02-20

Applicant: Dragonfly Therapeutics, Inc.

Inventor： Gregory P. Chang ,  Ann F. Cheung ,  William Haney ,  Bradley M. Lunde ,  Bianka Prinz

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/32

CPC classification number: C07K16/2851 ,  A61P35/00 ,  C07K16/283 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/732 ,  C07K2317/94

Abstract: Multi-specific binding proteins that bind HER2, the NKG2D receptor, and CD 16 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.

公开(公告)号：US20230303702A1

公开(公告)日：2023-09-28

申请号：US18150040

申请日：2023-01-04

Applicant: Dragonfly Therapeutics, Inc.

Inventor： Gregory P. Chang ,  Ann F. Cheung ,  Asya Grinberg ,  Eva Gutierrez ,  William Haney ,  Bradley M. Lunde ,  Nicolai Wagtmann ,  Bianka Prinz

IPC: C07K16/28 ,  A61P35/00 ,  A61K31/675 ,  A61K47/64 ,  C07K14/55 ,  A61K31/7084 ,  A61K31/337 ,  A61P35/02 ,  A61K39/395 ,  A61K47/69 ,  C07K16/32 ,  A61K39/00

CPC classification number: C07K16/2851 ,  A61K31/337 ,  A61K31/675 ,  A61K31/7084 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/643 ,  A61K47/6929 ,  A61P35/00 ,  A61P35/02 ,  C07K14/55 ,  C07K16/32 ,  C07K16/283 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/2878 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/94 ,  C07K2317/524 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/732 ,  C07K2317/734

Abstract: Combination therapy of a cancer with a multi-specific binding protein that bind a tumor associated antigen, the NKG2D receptor, and CD16, in combination with a second anti-cancer agent are described. Also described are pharmaceutical compositions of the multi-specific binding protein, and therapeutic methods useful for the treatment of cancer in combination with a second anti-cancer agent.

公开(公告)号：US20230272041A1

公开(公告)日：2023-08-31

申请号：US17920174

申请日：2021-04-22

Applicant: Dragonfly Therapeutics, Inc.

Inventor： Mitchell Bigelow ,  Alexandra Braun ,  Ann F. Cheung ,  Jean-Marie Cuillerot ,  Mark Derose ,  Asya Grinberg ,  Eva Gutierrez ,  Patrick Kirby ,  Christopher Ryan Morgan ,  Michael C. Naill ,  Steven O'Neil ,  Michael Shifrin ,  Nicolai Wagtmann

IPC: C07K14/735 ,  A61K31/7016 ,  A61K47/14 ,  A61K9/00 ,  A61P35/04 ,  C07K16/28 ,  A61K38/20 ,  A61K9/19

CPC classification number: C07K14/70535 ,  A61K31/7016 ,  A61K47/14 ,  A61K9/0019 ,  A61P35/04 ,  C07K16/2896 ,  A61K38/208 ,  A61K9/19

Abstract: The present invention relates to pharmaceutical formulations for heterodimeric Fc-fused proteins which are advantageous for achieving higher titers of the proteins during production, higher stability during storage, and improved efficacy when used as a therapeutic. Also provided are dosage regimens for such heterodimeric Fc-fused proteins and pharmaceutical formulations for use in treating cancer, such as locally advanced or metastatic solid tumor.

公开(公告)号：US20220119533A1

公开(公告)日：2022-04-21

申请号：US17287849

申请日：2019-10-23

Applicant: Dragonfly Therapeutics, Inc.

Inventor： Ann F. CHEUNG ,  Jean-Marie CULLEROT ,  Asya GRINBERG ,  Eva GUTIERREZ ,  William HANEY ,  Nicolai WAGTMANN

IPC: C07K16/28 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention provides Fc-fused protein constructs, which as monovalent dimers have a higher serum half-life compared to a native/natural molecule, and are, therefore, advantageous for achieving higher titers of the proteins during production, higher stability during storage, and improved efficacy when used as a therapeutic. Also provided are Fc-fused protein constructs having mutations in the Fc region that reduce effector functions, which have increased activity to inhibit tumor growth and are, therefore, advantageous when used as a cancer therapy.

公开(公告)号：US20220025037A1

公开(公告)日：2022-01-27

申请号：US17045015

申请日：2019-04-03

Applicant: Dragonfly Therapeutics, Inc.

Inventor： Hemanta Baruah ,  Ann F. Cheung ,  Daniel Fallon ,  Asya Grinberg ,  William Haney ,  Steven O'Neil

IPC: C07K16/28 ,  C12N15/86

Abstract: Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting DLL3 (Delta-like 3) on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.

公开(公告)号：US20210130496A1

公开(公告)日：2021-05-06

申请号：US16488395

申请日：2018-02-27

Applicant: Dragonfly Therapeutics, Inc.

Inventor： Gregory P. Chang ,  Ann F. Cheung ,  Eva Gutierrez ,  William Haney ,  Bradley M. Lunde ,  Bianka Prinz

IPC: C07K16/46 ,  C07K16/28

Abstract: Multi-specific binding proteins that bind the NKG2D receptor, CD 16, and a tumor-associated antigen selected from carbonic anhydrase 9 (CAIX), anoctamin-1 (ANO1), mesothelin, TROP2, CEA and claudin-18.2 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.

公开(公告)号：US20210130471A1

公开(公告)日：2021-05-06

申请号：US16486921

申请日：2018-02-20

Applicant: DRAGONFLY THERAPEUTICS, INC.

Inventor： Gregory P. CHANG ,  Ann F. CHEUNG ,  William HANEY ,  Bradley M. LUNDE ,  Bianka PRINZ

IPC: C07K16/28 ,  A61P35/00 ,  A61P35/04

Abstract: Multi-specific binding proteins that bind CD33, the NKG2D receptor, and CD 16 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.