公开(公告)号：US20240228645A1

公开(公告)日：2024-07-11

申请号：US18620375

申请日：2024-03-28

申请人： Dragonfly Therapeutics, Inc.

发明人： Benjamin FISCHER ,  Pyae P. HEIN ,  Alexander IVANOV ,  Xinbi LI ,  Matthew SCHNEIDER

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61K47/68 ,  C07K14/525 ,  C07K14/54 ,  C07K14/55 ,  C07K14/56 ,  C12N5/0783

CPC分类号： C07K16/2878 ,  A61K39/4611 ,  A61K39/4613 ,  A61K39/4631 ,  A61K39/4633 ,  A61K39/4643 ,  A61K47/68031 ,  A61K47/68033 ,  A61K47/68035 ,  A61K47/68037 ,  A61K47/6807 ,  A61K47/6849 ,  C07K14/525 ,  C07K14/5406 ,  C07K14/5428 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/55 ,  C07K14/56 ,  C07K16/2809 ,  C12N5/0636 ,  C12N5/0646 ,  C07K2317/31 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2510/00

摘要： Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting BAFF-R on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer or autoimmune disease.

公开(公告)号：US20240360223A1

公开(公告)日：2024-10-31

申请号：US18622766

申请日：2024-03-29

申请人： Dragonfly Therapeutics, Inc.

发明人： Aaron BELLI ,  Ann F. CHEUNG ,  Stacey V. DRABIC ,  Daniel FALLON ,  Benjamin FISCHER ,  Asya GRINBERG ,  Pyae P. HEIN ,  Alexander IVANOV ,  Zong Sean JUO ,  Mark LEWANDOWSKI ,  Xinbi LI ,  Matthew SCHNEIDER

IPC分类号： C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2851 ,  C07K16/283 ,  C07K16/2878 ,  A61K39/00 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76

摘要： Multispecific binding proteins that bind NKG2D receptor, CD16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.

公开(公告)号：US20240270861A1

公开(公告)日：2024-08-15

申请号：US18620824

申请日：2024-03-28

申请人： Dragonfly Therapeutics, Inc.

发明人： Aaron BELLI ,  Ann F. CHEUNG ,  Stacey V. DRABIC ,  Daniel FALLON ,  Benjamin FISCHER ,  Asya GRINBERG ,  Pyae P. HEIN ,  Alexander IVANOV ,  Zong Sean JUO ,  Mark LEWANDOWSKI ,  Xinbi LI ,  Matthew SCHNEIDER

IPC分类号： C07K16/28 ,  A61P35/00

CPC分类号： C07K16/2878 ,  A61P35/00 ,  C07K16/283 ,  C07K16/2851 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2319/21

摘要： Multispecific binding proteins that bind NKG2D receptor, CD16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.